國科會計畫統計

• 區間設限下一致性指標的半母數估計
  1140801~1150731
  

• 區間設限下一致性指標的半母數估計
  1130801~1140731
  

• 對主要終點為設限存活時間的三臂非劣臨床試驗設計使用參數與半母數模型
  1120801~1130731
  [延遲藥效,黃金標準,參數存活模型,半母數風險回歸模型 , Delayed treatment effects,Gold standard,Parametric survival model,Semiparametric hazards regression model]

• 改善以存活時間為主要目標的三臂等效性試驗所需樣本數的計算
  1110801~1121031
  [一致性指標,藥效晚發,受限最大概似估計量,半母數風險回歸模型 , Concordance index, Delayed treatment effects, RMLE, Semi-parametric hazards regression model]

• 臨床試驗設計及評估之創新統計方法-對於研究目的為存活時間的三臂等效性試驗所需樣本數的計算(子計畫四)
  1100801~1110731
  [非比例風險回歸模型,樣本數計算,三臂等效臨床試驗 , Non-proportionality hazards regression,Sample size determination,Three-arm equivalence trial]

• 臨床試驗設計及評估之創新統計方法-對於研究目的為存活時間的三臂等效性試驗所需樣本數的計算(子計畫四)
  1090801~1100731
  [非比例風險回歸模型,樣本數計算,三臂等效臨床試驗 , Non-proportionality hazards regression,Sample size determination,Three-arm equivalence trial]

• 以存活模型為基礎的時間相依接受者特徵曲線與預測精準度
  1080801~1100731
  [加速失敗模型,Cox 模型,聯合模型,時間相依曲線下面積 , AFT model,Cox model,Joint model,Time-dependent AUC]

• 以存活模型為基礎的時間相依接受者特徵曲線與預測精準度
  1070801~1080731
  [加速失敗模型,Cox 模型,聯合模型,時間相依曲線下面積 , AFT model,Cox model,Joint model,Time-dependent AUC]

• 一個含有長期追蹤資料的加乘法風險回歸模型
  1060801~1070731
  [聯合模型法,最大概似估計, 蒙地卡羅EM 演算法,加法風險模型,乘法風險模型 , Additive hazards models, Joint modeling, Maximum likelihood estimate, Monte Carlo EM algorithm, Multiplicative hazards models,]

• 聯合模型對於有時間相依供變數之復發事件使用廣義伽瑪脆弱因子
  1050801~1061031
  

• 聯合模型對於有時間相依供變數之復發事件使用廣義伽瑪脆弱因子
  1040801~1050731
  

產學合作計畫統計

• 第五屆台灣聯大學生統計論文研討會
  1060101~1061231
  [統計,台聯大系統 , Statistics, University System of Taiwan]

期刊著作

• Dual-mode recognition of tRNAPro isoacceptors by Toxoplasma gondii Prolyl-tRNA synthetase
  EMBO Reports, 2025-04-28
  [ Prolyl-tRNA synthetases, Evalution ]

• Adaptation of a eukaryote-like ProRS to a prokaryote-like tRNAPro
  Nucleic Acids Research, 52, 12, 7158-7170, 2024-07-08

• Adaptive evolution: Eukaryotic enzyme's specificity shift to a bacterial substrate
  Protein Science, 33, 6, 2024-06-01
  [ aminoacyl-tRNA synthetase,halofuginone,identity element,protein synthesis,thermophilic bacterium,tRNA ]

• A naturally occurring mini-alanyl-tRNA synthetase
  Communications Biology, 6, 1, 2023-12-01

• Sequence-specific targeting of Caenorhabditis elegans C-Ala to the D-loop of tRNAAla
  Journal of Biological Chemistry, 299, 9, 2023-09-01
  [ aminoacyl-tRNA synthetase,Caenorhabditis elegans,coevolution,DNA-binding domain,translation,tRNA-binding domain ]

• Recognition of tRNAHis in an RNase P-Free Nanoarchaeum
  Microbiology spectrum, 11, 2, 2023-03-01
  [ aminoacyl-TRNA synthetase,protein synthesis,RNase P,thermophilic archaeum,tRNA ]

• COMPARING THE EFFECTS OF PHYSICAL, VIRTUAL, AND HYBRID LABS ON PRIMARY SCHOOL STUDENTS’ CONCEPTUAL LEARNING OF HEAT AND TEMPERATURE
  Journal of Baltic Science Education, 22, 1, 153-166, 2023-01-01
  [ experimental design,heat and temperature,physical manipulative,virtual manipulative ]

• Gain of C-Ala enables AlaRS to target the L-shaped tRNAAla
  Nucleic Acids Research, 50, 4, 2190-2200, 2022-02-28

• Low concentrations of 4-ABP promote liver carcinogenesis in human liver cells and a zebrafish model
  Journal of Hazardous Materials, 423, 2022-02-05

• Likelihood-based analysis of doubly-truncated data under the location-scale and AFT model
  Computational Statistics, 36, 1, 375-408, 2021-03-01
  [ Accelerated life testing,Confidence band,Confidence interval,Newton–Raphson algorithm,Reliability,Weibull distribution ]

• Study design for a three-arm equivalence clinical trial with binomially distributed outcomes
  Journal of Biopharmaceutical Statistics, 31, 6, 736-744, 2021-01-01
  [ Binary outcome,equivalence test,sample size,superiority test,three-arm clinical trial ]

• 4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8
  Toxicology, 440, 2020-07-01

• The effects of visualization format and spatial ability on learning star motions
  Journal of Computer Assisted Learning, 36, 1, 61-69, 2020-02-01
  [ dynamic visualizations , motions of stars , spatial ability , static visualizations ]

• Joint modelling of longitudinal binary data and survival data
  Journal of Applied Statistics, 46, 13, 2357-2371, 2019-10-03
  [ Cox model , generalized linear model , metropolis-hastings algorithm , Monte Carlo EM algorithm , quality of life ]

• Naturally occurring dual recognition of tRNAHis substrates with and without a universal identity element
  RNA Biology, 16, 9, 1275-1285, 2019-09-02
  [ Aminoacyl,Caenorhabditis elegans,identity element,protein synthesis,translation,tRNA,tRNA synthetase ]

• Semiparametric transformation joint models for longitudinal covariates and interval-censored failure time
  Computational Statistics and Data Analysis, 128, 116-127, 2018-12-01
  [ Interval-censored data , Joint modelling , Longitudinal data , Self-consistency equation , Transformation models ]

• The Comparative Effectiveness of Physical, Virtual, and Virtual-Physical Manipulatives on Third-Grade Students’ Science Achievement and Conceptual Understanding of Evaporation and Condensation
  International Journal of Science and Mathematics Education, 16, 2, 203-219, 2018-02-01
  [ Conceptual understanding , Physical manipulative , Science achievement , Virtual manipulative ]

• A comparison of geometry problems in middle-grade mathematics textbooks from Taiwan, Singapore, Finland, and the United States
  Eurasia Journal of Mathematics, Science and Technology Education, 13, 7, 2841-2857, 2017-01-01
  [ Contextual features , Geometry , Middle-grade mathematics textbook , Representation forms , Response types ]

• Modulating the structure and function of an aminoacyl-trna synthetase cofactor by biotinylation
  Journal of Biological Chemistry, 291, 33, 17102-17111, 2016-08-12

• A Kernel Smooth Approach for Joint Modeling of Accelerated Failure Time and Longitudinal Data
  Communications in Statistics Part B: Simulation and Computation, 45, 4, 1240-1248, 2016-04-20
  [ AFT model,EM algorithm,Hazard smoothing,Joint model ]

• The change of microbial community from chlorinated solvent-contaminated groundwater after biostimulation using the metagenome analysis
  Journal of Hazardous Materials, 302, 144-150, 2016-01-25
  [ Dechlorination , Metagenome , Microbial community , Tetrachloroethane , Trichloroethene ]

• DO THINKING STYLES MATTER FOR SCIENCE ACHIEVEMENT AND ATTITUDES TOWARD SCIENCE CLASS IN MALE AND FEMALE ELEMENTARY SCHOOL STUDENTS IN TAIWAN?
  International Journal of Science and Mathematics Education, 13, 3, 515-533, 2015-06-01
  [ attitudes toward science class , gender difference , science achievement , thinking style ]

• Joint model of multiple longitudinal measures and a binary outcome: An application to predict orthostatic hypertension for subacute stroke patients
  Biometrical Journal, 57, 4, 661-675, 2015-01-01
  [ Joint model , Logistic regression , Multiple longitudinal measures , Orthostatic hypertension , Random effect model , Receiving operating characteristic curve ]

• An extended hazard model with longitudinal covariates
  Biometrika, 102, 1, 135-150, 2015-01-01
  [ Hazard smoothing , Joint modelling , Maximum likelihood estimation , Monte Carlo EM algorithm , Semiparametric likelihood ratio test ]

• MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells
  Toxicology, 322, 69-77, 2014-08-01
  [ DNA damage,DNA repair,MiRNA-513a-5p,MiRNA-630 ]

• Molecular mechanisms of 3,3'-dichlorobenzidine-mediated toxicity in HepG2 cells
  Environmental and Molecular Mutagenesis, 55, 5, 407-420, 2014-01-01
  [ '-dichlorobenzidine , 2D-DIGE , 3 , Apoptosis , Comet assay , HepG2 cells ]

• Risk of dementia after anaesthesia and surgery
  British Journal of Psychiatry, 204, 3, 188-193, 2014-01-01

• A semiparametric extended hazard regression model with time-dependent covariates
  Journal of Nonparametric Statistics, 26, 1, 115-128, 2014-01-01
  [ accelerated failure time model , Cox model , estimating function , extended hazard model , model misspecification , model selection ]

• An insertion peptide in yeast glycyl-tRNA synthetase facilitates both productive docking and catalysis of cognate tRNAs
  Molecular and Cellular Biology, 33, 17, 3515-3523, 2013-09-11

• Nonparametric profile monitoring in multi-dimensional data spaces
  Journal of Process Control, 22, 2, 397-403, 2012-02-01
  [ Block bootstrap , Confidence region , Nonparametric profile monitoring , Support Vector Regression ]

• Alanyl-tRNA synthetase genes of Vanderwaltozyma polyspora arose from duplication of a dual-functional predecessor of mitochondrial origin
  Nucleic Acids Research, 40, 1, 314-322, 2012-01-01

• Efficient estimation for a semiparametric extended hazards model
  Communications in Statistics Part B: Simulation and Computation, 40, 2, 258-273, 2011-01-01
  [ Accelerated failure time model , Extended hazards model , Kernel-smoothed profile likelihood , Likelihood ratio test , Proportional hazards model ]

• Age-specific and lifetime behavior patterns in Drosophila melanogaster and the Mediterranean fruit fly, Ceratitis capitata
  Experimental Gerontology, 41, 1, 93-97, 2006-01-01
  [ Behavioral gerontology,Degenerative behavior,Disability,Disablement,Impairment,Insect life span,Insect longevity,Supine behavior ]

• Joint modeling of survival and longitudinal data: Likelihood approach revisited
  Biometrics, 62, 4, 1037-1043, 2006-01-01
  [ Joint modeling,Missing information principle,Nonparametric maximum likelihood,Posterior density,Profile likelihood ]

• Joint modelling of accelerated failure time and longitudinal data
  Biometrika, 92, 3, 587-603, 2005-09-01
  [ EM algorithm , Measurement error , Missing data , Monte Carlo integration , Random effect , Survival data ]

• A comparison between linear and nonlinear forecasts for nonlinear AR models
  Journal of Forecasting, 16, 7, 491-508, 1997-01-01
  [ Forecast origin,Multi-step forecast,SETAR model ]