高教深耕計畫

• 開發體外聽毛細胞晶片應用於損藥物篩檢
  1140101~1141231
  [藥物篩檢 ]

• 建立體外椎間盤退化疾病檢測器官晶片
  1140101~1141231
  

• 建立預貼盤初級耳蝸細胞純化方式應用於聽力再生
  1130101~1131231
  

• 以體外生物反應系統探討仿生子宮內膜類組織與三維MSC球體之交互作用
  1120101~1121231
  

• 結合三維積層製造技術及再生醫學策略於聽損研究之應用
  1120101~1121231
  

• 新進/年輕教師學術研究補助-陳靖昀
  1110101~1111220
  

• 建立體外仿生內耳微器官培養平台
  1110101~1111231
  [聽損,三維培養技術,仿生內耳微器官 , Sensorineural Hearing Loss,3D Cell Culture Technique,Biomimetic Inner Ear Organoid]

國科會計畫統計

• 建立體外動態離子調控系統模擬內淋巴微環境應用於內耳非動物替代檢測平台
  1130801~1140731
  

• 常溫細胞儲存和運輸之仿生微載體應用於再生製劑開發
  1120801~1130831
  [仿生微膠囊,動態培養,常溫運輸,微流道系統,細胞團塊 , Bionic micro-capsules,dynamic culture system,ambient temperature transportation,microfluidic system,cell body]

• 開發耳科非動物替代體外藥物篩選平台
  1110901~1120831
  [感音性聽損、耳蝸微器官、內淋巴微環境、離子調控、細胞馴化 , sensorineural hearing loss (SNHL),cochlear organoids,endolymphatic microenvironment,ion regulation,cell adaptation]

• 開發個人化生物活性硬骨移植醫材應用於精準醫療
  1100801~1111031
  [個人化類硬骨器官團塊,共培養,三維列印,生物活性,客製化仿生骨 , personalized bone-like organoids,co-culture,3D-printing,bioactive,customized biomimetic bone grafts]

產學合作計畫統計

• 醫療器材清潔確效
  1131230~1140630
  [清潔確效,細胞毒性,微粒測試 , 無]

• 清潔確效(微粒測試、細胞毒性)、動物實驗、合作案之樣品製作及英文結案報告
  1130221~1131220
  [清潔確效,微粒測試,細胞毒性 , 無]

• 可溶性止血材料於小鼠出血模型之功效性研究
  1120815~1121231
  [止血材料 , Hemostatic Materials]

• 應用三維積層製造技術開發規格化仿生皮膚組織體外培養系統
  1110601~1120731
  [N/A , N/A]

• 多功能生醫水膠
  1101015~1101215
  [生物相容性 , biocompatibility]

• 110年中大聯新醫院聯合研發中心計畫-建立體外三維仿皮膚模型應用於燒燙傷皮膚重建
  1100801~1120630
  [燒燙傷、三維培養技術、客製化仿生皮膚組織 , Burn Injury,3D Cell Culture Technique,Customized Biomimetic Organotypic Skin]

• Bioink生物相容性/降解性/膨脹率委託檢測
  1100501~1101031
  [生物墨水 , Bioink]

期刊著作

• Inner Ear Multiple Primary Cell Type Detection System
  Scientific data, 12, 1, 2025-12-01

• The alterations of molecular repertoire of the RANKL-induced osteoclastogenesis in the M1 macrophage-derived inflammatory milieu
  Scientific Reports, 15, 1, 2025-12-01
  [ Inflammation,Inflammatory milieu,Osteoclastogenesis,Pro-inflammatory cytokines ]

• A facile ultrasound-assisted synthesis and DFT evaluation of 3D hierarchical tin disulfide nanoflowers
  Next Materials, 8, 2025-07-01
  [ 3D hierarchical,DFT,Nanoflowers,SnS2,Sonochemical synthesis ]

• A flexible, sustainable, and deep learning-assisted triboelectric patch for self-powered interactive sensing and wound healing applications
  Nano Energy, 134, 2025-02-01
  [ Deep learning,Electrical stimulation,Nanocomposite,Sustainable,Triboelectricity ]

• Biodegradable hafnium-doped CaCO3 nanoparticles as a dual-modality radiosensitizer for cancer radiotherapy
  Nanomedicine, 19, 13, 1133-1144, 2024-01-01
  [ bioceramics,cancer/oncology,nanomaterials,nanoparticles,therapeutics ]

• Nature-Inspired Surface Structures Design for Antimicrobial Applications
  International Journal of Molecular Sciences, 24, 2, 2023-01-01
  [ anti-bacteria,anti-biofouling,anti-virus,antimicrobial surface,structure,surface topography ]

• In vitro evaluation of injectable Tideglusib-loaded hyaluronic acid hydrogels incorporated with Rg1-loaded chitosan microspheres for vital pulp regeneration
  Carbohydrate Polymers, 278, 2022-02-15

• The Synthesis of Europium-Doped Calcium Carbonate by an Eco-Method as Free Radical Generator Under Low-Intensity Ultrasonic Irradiation for Body Sculpture
  Frontiers in Bioengineering and Biotechnology, 9, 2021-11-19
  [ body sculpture,calcium carbonate,europium,reactive oxygen species,ultrasound ]

• Alginate-gelatin based core-shell capsule enhances the osteogenic potential of human osteoblast-like MG-63 cells
  Materials and Design, 210, 2021-11-15
  [ 3D culture,Alginate,Core–shell capsule,Gelatin,Osteogenesis ]

• The synthesis and evaluation of RGD−conjugated chitosan gel as daily supplement for body weight control
  Materials, 14, 16, 2021-08-02
  [ Chitosan,Highly biocompatibility,Obesity,RGD,Type 2 diabetes ]

• Preparation and in-vitro evaluation of Fe2O3-doped DP-bioglass in combination with 3D-printing and selective laser sintering process (3DP-SLS) for alveolar bone augmentation
  Ceramics International, 47, 9, 12725-12734, 2021-05-01
  [ 3D-printing,Alveolar bone substitute,Bioglass,Selective laser sintering ]

• Kartogenin enhances chondrogenic differentiation of mscs in 3d tri-copolymer scaffolds and the self-designed bioreactor system
  Biomolecules, 11, 1, 1-20, 2021-01-01
  [ 3D culture,Chondrogenic differentiation,Kartogenin,MSCs,Self-designed bioreactor system,Tri-copolymer scaffolds ]

• Using c-doped TiO2 nanoparticles as a novel sonosensitizer for cancer treatment
  Antioxidants, 9, 9, 1-18, 2020-09-01
  [ Breast cancer treatment,Cancer treatment,Carbon doped titanium dioxide,Sonodynamic therapy,Sonosensitizers,Ultrasound ]

• Enhancement of neurite outgrowth by warming biomaterial ultrasound treatment
  International Journal of Molecular Sciences, 21, 6, 2020-03-02
  [ Acoustic attenuation,Neurite outgrowth,Sonosensitized biomaterial,Thermal effect,Ultrasound ]

• Cooperative impact of thiazolidinedione and fatty acid synthase on human osteogenesis
  Aging, 11, 8, 2327-2342, 2019-04-30
  [ 3-dimentional culture,Autologous cell therapy,Bioreactor,Bone-like tissues,Thiazolidinedione ]

• The preparation of oxidized methylcellulose crosslinked by adipic acid dihydrazide loaded with vitamin C for traumatic brain injury
  Journal of Materials Chemistry B, 7, 29, 4499-4508, 2019-01-01

• Overexpression of insulin-like growth factor 1 enhanced the osteogenic capability of aging bone marrow mesenchymal stem cells
  Theranostics, 7, 6, 1598-1611, 2017-01-01
  [ Aging-related bone loss,Bioreactor,Bone marrow MSC,IGF-1,Osteoporosis ]

• Development of gelatin nanoparticles conjugated with phytohemagglutinin erythroagglutinating loaded with gemcitabine for inducing apoptosis in non-small cell lung cancer cells
  Journal of Materials Chemistry B, 4, 14, 2444-2454, 2016-04-14

• 3D cell clusters combined with a bioreactor system to enhance the drug metabolism activities of C3A hepatoma cell lines
  Journal of Materials Chemistry B, 4, 43, 7000-7008, 2016-01-01

• Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity
  BMC Complementary and Alternative Medicine, 15, 1, 2015-09-14
  [ Activation,Anti-inflammation,Harpagoside,Hypoxia,Microglial cells ]

• ROS-induced toxicity: exposure of 3T3, RAW264.7, and MCF7 cells to superparamagnetic iron oxide nanoparticles results in cell death by mitochondria-dependent apoptosis
  Journal of Nanoparticle Research, 17, 2, 2015-02-01
  [ Cancer,Environmental and health effects,Iron oxide,Mitochondria,ROS,Superparamagnetic ]

• Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage
  BMC Complementary and Alternative Medicine, 15, 1, 2015-01-24
  [ 20-Hydroxyecdysone,Cartilage destruction,HIF-2α,Hypoxia,IL-1β,Normoxia ]

• Fabrication of keratin/fibroin membranes by electrospinning for vascular tissue engineering
  Journal of Materials Chemistry B, 4, 2, 237-244, 2015-01-01

• 3D porous calcium-alginate scaffolds cell culture system improved human osteoblast cell clusters for cell therapy
  Theranostics, 5, 6, 643-655, 2015-01-01
  [ Autografts,Bone-like tissues,Perfusion,Preformed scaffolds,Three-dimensional culture ]

• A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis
  Journal of the Formosan Medical Association, 113, 11, 803-812, 2014-01-01
  [ Cartilage,Col2a1,Homeostasis,Phenotype,Transgenic mice ]

• Facile method for gold nanocluster synthesis and fluorescence control using toluene and ultrasound
  Journal of Medical and Biological Engineering, 33, 1, 23-28, 2013-03-19
  [ Au,Composition,Fluorescence,Nanoclusters,Ultrasound ]

專書

• Experimental Acupuncturology
  81-94, 2018-01-01
  [ Acupuncture,Chemotherapy-induced peripheral neuropathy,Diabetic peripheral neuropathy,Nerve regeneration,Neurotrophin ]