國立中央大學教師履歷平台

教師個人簡歷

中文姓名

劉淑貞

英文姓名

Shu-Chen Liu

電子郵件

jennyliu@g.ncu.edu.tw

nasopharyngeal carcinoma EB病毒 Epstein-Barr virus 頭頸腫瘤微環境 EBV tumor microenvironment leukemia inhibitory factor LMP1 腫瘤基質外吐小體成纖維母細胞 EBV潛伏膜蛋白-1 鼻咽癌腫瘤免疫學癌症治療抗性分子機制 Cancer single cell genomics Cancer therapeutic resistance Epstein-Barr virus in NPC carcinogenesis 腫瘤單細胞基因體學與癌症單細胞基因體腫瘤免疫 EB病毒與癌症癌症治療抗性醫學工程

現職	國立中央大學生醫理工學院生醫科學與工程學系副教授
專長	頭頸腫瘤微環境 EB病毒(EBV)與癌症癌症治療抗性分子機制腫瘤免疫學腫瘤單細胞基因體學 Nasopharyngeal carcinoma Tumor microenvironment Epstein-Barr virus in NPC carcinogenesis Cancer therapeutic resistance Cancer single cell genomics
專長簡述	頭頸腫瘤微環境、EB病毒與癌症、癌症治療抗性、腫瘤免疫、單細胞基因體
最高學歷	國防醫學院生命科學研究所博士
相關連結	個人網頁 GRB資訊系統

科技部學門領域	B - 生命科學 B10 - 醫學 B10B0 - 生化及藥理醫學 B10B002 - 醫學生化及分子生物 B10Q0 - 血液免疫醫學 B10Q002 - 腫瘤 E - 工程及應用科學 E17 - 醫學工程 E1701 - 醫用電子
政府GRB研究專長領域	2 - 工 29 - 醫學工程 4 - 醫 40 - 基礎醫學 4L - 生物技術(醫)
教育部學門領域	5 - 工程、製造及營造 52 - 工程學門 5211 - 生醫工程學類

高教深耕計畫

108年榮總台灣聯大-EBV病毒相關外吐小體對鼻咽腫瘤基質的調控
1080101~1081231

國科會計畫統計

探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發
1140801~1150731
探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發
1130801~1140731
探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發
1120801~1130731
白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制
1110801~1121031
[口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]
白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制
1100801~1110731
[口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]
白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制
1090801~1100731
[口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]
含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控-II
1080801~1090731
[鼻咽癌, 外吐小體,成纖維母細胞,腫瘤基質,EB病毒,EBV潛伏膜蛋白-1, 微環境 , Epstein-Barr virus, nasopharyngeal carcinoma, stroma, LMP1, microenvironment, fibroblasts.]
含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控
1071101~1090131
[鼻咽癌, 外吐小體,成纖維母細胞,腫瘤基質,EB病毒,EBV潛伏膜蛋白-1 , nasopharyngeal carcinoma, exosome, fibroblasts, tumor stroma, Epstein-Barr virus, LMP1]
EBV病毒調控脂肪細胞分化並重建腫瘤微環境
1060801~1070731
[EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]
EBV病毒調控脂肪細胞分化並重建腫瘤微環境
1050801~1060731
[EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]
EBV病毒調控脂肪細胞分化並重建腫瘤微環境
1040801~1050731
[EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]

期刊著作

Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment
Virology Journal, 22, 1, 2025-12-01
[ Cell death,Nasopharyngeal carcinoma,NK cells,Oncolytic-attenuated ORFV,Xenograft model ]
Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming
Oncogenesis, 14, 1, 2025-12-01
Photoactive nanocatalysts as DTT-assisted BSA-AuNCs with enhanced oxidase-mimicking ability for sensitive fluorometric detection of antioxidants
Journal of Nanobiotechnology, 22, 1, 2024-12-01
[ Antioxidants,DTT@BSA-AuNCs,Fluorescence,Oxidase-like nanozymes,Photocatalysis ]
A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma
Discover Oncology, 14, 1, 2023-12-01
[ CDH4,CYLD,EBV-encoded LMP1,Nasopharyngeal carcinoma,STAT4 ]
Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts
Journal of Experimental and Clinical Cancer Research, 41, 1, 2022-08-20
[ EBV,Epstein-Barr virus,Exosome,FAPα,Fibroblast,Fibroblast activation protein alpha,Fibrosis,Nasopharyngeal carcinoma,NPC,YAP1 ]
Characterization of recurrent relevant genes reveals a novel role of rpl36a in radioresistant oral squamous cell carcinoma
Cancers, 13, 22, 2021-11-01
[ Oral cancer,Oral cavity squamous cell carcinoma,OSCC,Radioresistance,Radiotherapy,RPL36A ]
Epstein-barr virus induces adipocyte dedifferentiation to modulate the tumor microenvironment
Cancer Research, 81, 12, 3283-3294, 2021-06-01
miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma
Neoplasia, 22, 12, 789-799, 2020-12-01
[ BRAF inhibitor,Melanoma,miR-524-5p,miRNA,Resistance ]
WNK1 kinase stimulates angiogenesis to promote tumor growth and metastasis
Cancers, 12, 3, 2020-03-01
[ Colorectal cancer , Hepatocellular carcinoma , Tumor-induced angiogenesis , With-no-lysine (K) kinase I , Zebrafish ]
Association of subcutaneous and visceral adipose tissue with overall survival in Taiwanese patients with bone metastases – results from a retrospective analysis of consecutively collected data
PLoS ONE, 15, 1, 2020-01-01
Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer
Journal of Geriatric Oncology, 10, 5, 757-762, 2019-09-01
Tail shape evolution dynamics of MDCK cells on fibronectin substrates
Biomedical Physics and Engineering Express, 5, 4, 2019-05-16
[ actin filament , cell migration , cell shape evolution , focal adhesion , tail retraction , treadmilling motion ]
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
Nature Communications, 9, 1, 2018-12-01
Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation
Physical Review Letters, 121, 1, 2018-07-03
EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model
Journal of Immunology, 194, 9, 4577-4587, 2015-01-01
Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis
Molecular and Cellular Oncology, 1, 1, 2014-01-01
[ Epstein-Barr virus , leukemia inhibitory factor , mTOR , nasopharyngeal carcinoma , p70S6K , radioresistance ]
Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma
Journal of Proteome Research, 13, 11, 4796-4807, 2014-01-01
[ biomarker , oral cavity squamous cell carcinoma , primary cell , saliva , secretome , thrombospondin-2 ]
Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance
Journal of Clinical Investigation, 123, 12, 5269-5283, 2013-12-02
Epstein-barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells
PLoS Pathogens, 8, 5, 2012-05-01
Quantitative plasma proteome analysis reveals aberrant level of blood coagulation-related proteins in nasopharyngeal carcinoma
Journal of Proteomics, 74, 5, 744-757, 2011-05-01
[ Blood coagulation , Nasopharyngeal carcinoma , Plasma kallikrein , Plasma proteome , Protein fractionation , Tumor marker ]
Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway
, 88, 15, 3308-3318, 2010-11-15
[ Cell culture , Cell proliferation , Cochlea , Cytokines , Leukemia inhibitory factor , Neural stem cell ]
Gα12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization
Cancer Research, 69, 15, 6122-6130, 2009-08-01
Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
Journal of Virology, 80, 18, 8989-8999, 2006-09-01
A bayes regression approach to array-CGH data
Statistical Applications in Genetics and Molecular Biology, 5, 1, 2006-01-01
[ Change point problem , Comparative genomic hybridization , DNA copy number imbalance ]

研討會著作

Bimetallic photonanozyme catalysts for fluorometric analysis of total antioxidant capacity in human saliva
2025-01-01
[ Bimetallic nanocluster,Fluorescence assay,Oxidative stress,Photonanozyme,Reactive oxygen species,Total antioxidative capacity ]
Deciphering the Systemic Immune Responses Mediated by Radiotherapy in Stage I NPC Patients
2024-08-03
[ radiotherapy,immune,nasopharyngeal carcinoma ]
Radiotherapy-mediated immune modulatory responses in patients with stage I nasopharyngeal carcinoma
2024-05-04
[ immune response,nasopharyngeal carcinoma ]
Leukemia Inhibitory Factor Modulates Macrophage Immune Response Through YAP1 signaling in Oral Squamous Cell Carcinoma.
2023-05-06
[ LIF, leukemia inhibitory factor, macrophage, oral cancer ]
The multifaceted roles of leukemia inhibitor factor in tuning the immune microenvironment of oral squamous cell carcinoma
200, 2023-05-06
[ 頭頸癌，免疫治療，白血病抑制因子，單細胞定序，腫瘤微環境，免疫檢查點 ]
EBV positive NPC-derived exosomes promote macrophage M2 polarization via activating MST1R signaling
200, 2023-05-06
[ Epstein-Barr virus, EBV, nasopharyngeal carcinoma, NPC, exosome ]
Leukemia inhibitory factor regulates macrophage immune response in head and neck squamous cell carcinoma
2023-04-14
[ LIF, leukemia inhibitory factor, macrophage, oral cancer ]
EBV positive NPC-derived exosomes promote macrophage M2 polarization via activating MST1R and YAP1 signalings
2023-04-14
[ Epstein-Barr virus, EBV, nasopharyngeal carcinoma, exosome, macrophage ]
NPC-Derived Exosomal LMP1 Promotes Macrophage M2 Polarization Via Activating MST1R Signaling
2023-03-18
[ Epstein-Barr virus, latent membrane protein 1, exosome ]
Systemic Immune Signatures Associated with Radiation Therapy in Nasopharyngeal Carcinoma at Single-Cell Resolution.
2022-12-10
[ radiotherapy, radiation, single-cell, radioresistance ]
Leukemia Inhibitor Factor Promotes Polarization and Immune Regulations of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma
2022-04-30
[ leukemia inhibitory factor, oral cancer, tumor microenvironment, macrophage ]
Investigating the Role of NPC-Derived Exosomes in Regulating Macrophage Immunity
2022-04-30
[ exosome, macrophage, immune, nasopharyngeal carcinoma ]
Decoding the Systemic Immune Signatures Associated with Radiation Therapy in Nasopharyngeal Carcinoma
2022-04-30
[ radiation, radiotherapy, single cell sequencing, nasopharyngeal carcinoma ]
EBV-products containing exosomes remodel NPC tumor microenvironment by activating fibroblasts
Cancer Res 2022;82(12_Suppl):Abstract nr 3192., 2022-04-08
[ fibroblast, exosome, nasopharygeal carcinoma ]
Nasopharyngeal Carcinoma-Derived EBV Products-Containing Exosomes Regulate Macrophage Polarization and Immune Responses
2022-03-26
[ nasopharyngeal carcinoma, immune, macrophage ]
Investigating the NPC-derived Exosomes-Mediated Effects on Macrophage Polarization and Immune Response
2021-09-04
[ macrophage, immune response, NPC, RNA sequencing ]
EBV Product-Containing Exosomes Remodel the Tumor Microenvironment by Activating Stromal Fibroblasts
2021-09-04
[ exosome, fibroblast, EBV, NPC ]
Emerging role of exosomes in cancer: clinical insights and diagnostic potential
2021-06-05
[ exosome, cancer ]
Interactions between Epstein-Barr virus and tumor-associated adipocytes
2020-03-02
[ EBV, adipocyte, tumor microenvironment, lipid ]
Epstein-Barr virus dedifferentiates adipocytes and modulates tumor microenvironment
2019-05-04
[ EBV, fibroblast, adipocyte differentiation ]
The Molecular basis of LIF-mediated NPC metastasis
79, 2019-03-29
[ nasopharyngeal caricinoma, LIF, YAP1, focal adhesion ]
SRC-YAP1 Signaling Modulates Activation of Fibroblasts in the NPC Tumor Microenvironment
2018-06-10
[ YAP1, NPC, SRC ]

高教深耕計畫

108年榮總台灣聯大-EBV病毒相關外吐小體對鼻咽腫瘤基質的調控 1080101~1081231

國科會計畫統計

探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發 1140801~1150731

探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發 1130801~1140731

探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發 1120801~1130731

白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制 1110801~1121031 [口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]

白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制 1100801~1110731 [口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]

白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制 1090801~1100731 [口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]

含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控-II 1080801~1090731 [鼻咽癌, 外吐小體,成纖維母細胞,腫瘤基質,EB病毒,EBV潛伏膜蛋白-1, 微環境 , Epstein-Barr virus, nasopharyngeal carcinoma, stroma, LMP1, microenvironment, fibroblasts.]

含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控 1071101~1090131 [鼻咽癌, 外吐小體,成纖維母細胞,腫瘤基質,EB病毒,EBV潛伏膜蛋白-1 , nasopharyngeal carcinoma, exosome, fibroblasts, tumor stroma, Epstein-Barr virus, LMP1]

EBV病毒調控脂肪細胞分化並重建腫瘤微環境 1060801~1070731 [EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂 肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]

EBV病毒調控脂肪細胞分化並重建腫瘤微環境 1050801~1060731 [EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂 肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]

EBV病毒調控脂肪細胞分化並重建腫瘤微環境 1040801~1050731 [EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂 肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]

期刊著作

Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment Virology Journal, 22, 1, 2025-12-01 [ Cell death,Nasopharyngeal carcinoma,NK cells,Oncolytic-attenuated ORFV,Xenograft model ]

Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming Oncogenesis, 14, 1, 2025-12-01

Photoactive nanocatalysts as DTT-assisted BSA-AuNCs with enhanced oxidase-mimicking ability for sensitive fluorometric detection of antioxidants Journal of Nanobiotechnology, 22, 1, 2024-12-01 [ Antioxidants,DTT@BSA-AuNCs,Fluorescence,Oxidase-like nanozymes,Photocatalysis ]

A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma Discover Oncology, 14, 1, 2023-12-01 [ CDH4,CYLD,EBV-encoded LMP1,Nasopharyngeal carcinoma,STAT4 ]

Characterization of recurrent relevant genes reveals a novel role of rpl36a in radioresistant oral squamous cell carcinoma Cancers, 13, 22, 2021-11-01 [ Oral cancer,Oral cavity squamous cell carcinoma,OSCC,Radioresistance,Radiotherapy,RPL36A ]

Epstein-barr virus induces adipocyte dedifferentiation to modulate the tumor microenvironment Cancer Research, 81, 12, 3283-3294, 2021-06-01

miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma Neoplasia, 22, 12, 789-799, 2020-12-01 [ BRAF inhibitor,Melanoma,miR-524-5p,miRNA,Resistance ]

WNK1 kinase stimulates angiogenesis to promote tumor growth and metastasis Cancers, 12, 3, 2020-03-01 [ Colorectal cancer , Hepatocellular carcinoma , Tumor-induced angiogenesis , With-no-lysine (K) kinase I , Zebrafish ]

Association of subcutaneous and visceral adipose tissue with overall survival in Taiwanese patients with bone metastases – results from a retrospective analysis of consecutively collected data PLoS ONE, 15, 1, 2020-01-01

Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer Journal of Geriatric Oncology, 10, 5, 757-762, 2019-09-01

Tail shape evolution dynamics of MDCK cells on fibronectin substrates Biomedical Physics and Engineering Express, 5, 4, 2019-05-16 [ actin filament , cell migration , cell shape evolution , focal adhesion , tail retraction , treadmilling motion ]

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling Nature Communications, 9, 1, 2018-12-01

Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation Physical Review Letters, 121, 1, 2018-07-03

EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model Journal of Immunology, 194, 9, 4577-4587, 2015-01-01

Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis Molecular and Cellular Oncology, 1, 1, 2014-01-01 [ Epstein-Barr virus , leukemia inhibitory factor , mTOR , nasopharyngeal carcinoma , p70S6K , radioresistance ]

Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma Journal of Proteome Research, 13, 11, 4796-4807, 2014-01-01 [ biomarker , oral cavity squamous cell carcinoma , primary cell , saliva , secretome , thrombospondin-2 ]

Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance Journal of Clinical Investigation, 123, 12, 5269-5283, 2013-12-02

Epstein-barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells PLoS Pathogens, 8, 5, 2012-05-01

Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway , 88, 15, 3308-3318, 2010-11-15 [ Cell culture , Cell proliferation , Cochlea , Cytokines , Leukemia inhibitory factor , Neural stem cell ]

Gα12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization Cancer Research, 69, 15, 6122-6130, 2009-08-01

Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus Journal of Virology, 80, 18, 8989-8999, 2006-09-01

A bayes regression approach to array-CGH data Statistical Applications in Genetics and Molecular Biology, 5, 1, 2006-01-01 [ Change point problem , Comparative genomic hybridization , DNA copy number imbalance ]

研討會著作

Bimetallic photonanozyme catalysts for fluorometric analysis of total antioxidant capacity in human saliva 2025-01-01 [ Bimetallic nanocluster,Fluorescence assay,Oxidative stress,Photonanozyme,Reactive oxygen species,Total antioxidative capacity ]

Deciphering the Systemic Immune Responses Mediated by Radiotherapy in Stage I NPC Patients 2024-08-03 [ radiotherapy,immune,nasopharyngeal carcinoma ]

Radiotherapy-mediated immune modulatory responses in patients with stage I nasopharyngeal carcinoma 2024-05-04 [ immune response,nasopharyngeal carcinoma ]

Leukemia Inhibitory Factor Modulates Macrophage Immune Response Through YAP1 signaling in Oral Squamous Cell Carcinoma. 2023-05-06 [ LIF, leukemia inhibitory factor, macrophage, oral cancer ]

The multifaceted roles of leukemia inhibitor factor in tuning the immune microenvironment of oral squamous cell carcinoma 200, 2023-05-06 [ 頭頸癌，免疫治療，白血病抑制因子，單細胞定序，腫瘤微環境，免疫檢查點 ]

EBV positive NPC-derived exosomes promote macrophage M2 polarization via activating MST1R signaling 200, 2023-05-06 [ Epstein-Barr virus, EBV, nasopharyngeal carcinoma, NPC, exosome ]

Leukemia inhibitory factor regulates macrophage immune response in head and neck squamous cell carcinoma 2023-04-14 [ LIF, leukemia inhibitory factor, macrophage, oral cancer ]

EBV positive NPC-derived exosomes promote macrophage M2 polarization via activating MST1R and YAP1 signalings 2023-04-14 [ Epstein-Barr virus, EBV, nasopharyngeal carcinoma, exosome, macrophage ]

NPC-Derived Exosomal LMP1 Promotes Macrophage M2 Polarization Via Activating MST1R Signaling 2023-03-18 [ Epstein-Barr virus, latent membrane protein 1, exosome ]

Systemic Immune Signatures Associated with Radiation Therapy in Nasopharyngeal Carcinoma at Single-Cell Resolution. 2022-12-10 [ radiotherapy, radiation, single-cell, radioresistance ]

Leukemia Inhibitor Factor Promotes Polarization and Immune Regulations of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma 2022-04-30 [ leukemia inhibitory factor, oral cancer, tumor microenvironment, macrophage ]

Investigating the Role of NPC-Derived Exosomes in Regulating Macrophage Immunity 2022-04-30 [ exosome, macrophage, immune, nasopharyngeal carcinoma ]

Decoding the Systemic Immune Signatures Associated with Radiation Therapy in Nasopharyngeal Carcinoma 2022-04-30 [ radiation, radiotherapy, single cell sequencing, nasopharyngeal carcinoma ]

EBV-products containing exosomes remodel NPC tumor microenvironment by activating fibroblasts Cancer Res 2022;82(12_Suppl):Abstract nr 3192., 2022-04-08 [ fibroblast, exosome, nasopharygeal carcinoma ]

Nasopharyngeal Carcinoma-Derived EBV Products-Containing Exosomes Regulate Macrophage Polarization and Immune Responses 2022-03-26 [ nasopharyngeal carcinoma, immune, macrophage ]

Investigating the NPC-derived Exosomes-Mediated Effects on Macrophage Polarization and Immune Response 2021-09-04 [ macrophage, immune response, NPC, RNA sequencing ]

EBV Product-Containing Exosomes Remodel the Tumor Microenvironment by Activating Stromal Fibroblasts 2021-09-04 [ exosome, fibroblast, EBV, NPC ]

Emerging role of exosomes in cancer: clinical insights and diagnostic potential 2021-06-05 [ exosome, cancer ]

Interactions between Epstein-Barr virus and tumor-associated adipocytes 2020-03-02 [ EBV, adipocyte, tumor microenvironment, lipid ]

Epstein-Barr virus dedifferentiates adipocytes and modulates tumor microenvironment 2019-05-04 [ EBV, fibroblast, adipocyte differentiation ]

The Molecular basis of LIF-mediated NPC metastasis 79, 2019-03-29 [ nasopharyngeal caricinoma, LIF, YAP1, focal adhesion ]

SRC-YAP1 Signaling Modulates Activation of Fibroblasts in the NPC Tumor Microenvironment 2018-06-10 [ YAP1, NPC, SRC ]

108年榮總台灣聯大-EBV病毒相關外吐小體對鼻咽腫瘤基質的調控
1080101~1081231

探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發
1140801~1150731

探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發
1130801~1140731

探索以LIF及LIFR為標靶的頭頸腫瘤免疫輔助治療潛能與抑制劑開發
1120801~1130731

白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制
1110801~1121031
[口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]

白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制
1100801~1110731
[口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]

白血病抑制因子於口腔鱗狀上皮細胞癌的免疫調控機制
1090801~1100731
[口腔鱗狀上皮細胞癌,白血病抑制因子,單細胞定序 , oral squamous cell carcinoma,leukemia inhibitory factor,LIF,single cell RNA sequencing]

含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控-II
1080801~1090731
[鼻咽癌, 外吐小體,成纖維母細胞,腫瘤基質,EB病毒,EBV潛伏膜蛋白-1, 微環境 , Epstein-Barr virus, nasopharyngeal carcinoma, stroma, LMP1, microenvironment, fibroblasts.]

含EBV病毒產物之外吐小體對鼻咽癌細胞及微環境基質細胞的調控
1071101~1090131
[鼻咽癌, 外吐小體,成纖維母細胞,腫瘤基質,EB病毒,EBV潛伏膜蛋白-1 , nasopharyngeal carcinoma, exosome, fibroblasts, tumor stroma, Epstein-Barr virus, LMP1]

EBV病毒調控脂肪細胞分化並重建腫瘤微環境
1060801~1070731
[EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]

EBV病毒調控脂肪細胞分化並重建腫瘤微環境
1050801~1060731
[EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]

EBV病毒調控脂肪細胞分化並重建腫瘤微環境
1040801~1050731
[EB病毒,EBV病毒,脂肪細胞,腫瘤微環境,脂肪細胞分化,脂肪細胞去分化 , EBV, Epstein-Barr virus, adipocyte, tumor microenvironment, adipocyte differentiation, adipocyte dedifferentiation]

Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment
Virology Journal, 22, 1, 2025-12-01
[ Cell death,Nasopharyngeal carcinoma,NK cells,Oncolytic-attenuated ORFV,Xenograft model ]

Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming
Oncogenesis, 14, 1, 2025-12-01

Photoactive nanocatalysts as DTT-assisted BSA-AuNCs with enhanced oxidase-mimicking ability for sensitive fluorometric detection of antioxidants
Journal of Nanobiotechnology, 22, 1, 2024-12-01
[ Antioxidants,DTT@BSA-AuNCs,Fluorescence,Oxidase-like nanozymes,Photocatalysis ]

A 3-gene signature comprising CDH4, STAT4 and EBV-encoded LMP1 for early diagnosis and predicting disease progression of nasopharyngeal carcinoma
Discover Oncology, 14, 1, 2023-12-01
[ CDH4,CYLD,EBV-encoded LMP1,Nasopharyngeal carcinoma,STAT4 ]

Characterization of recurrent relevant genes reveals a novel role of rpl36a in radioresistant oral squamous cell carcinoma
Cancers, 13, 22, 2021-11-01
[ Oral cancer,Oral cavity squamous cell carcinoma,OSCC,Radioresistance,Radiotherapy,RPL36A ]

Epstein-barr virus induces adipocyte dedifferentiation to modulate the tumor microenvironment
Cancer Research, 81, 12, 3283-3294, 2021-06-01

miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma
Neoplasia, 22, 12, 789-799, 2020-12-01
[ BRAF inhibitor,Melanoma,miR-524-5p,miRNA,Resistance ]

WNK1 kinase stimulates angiogenesis to promote tumor growth and metastasis
Cancers, 12, 3, 2020-03-01
[ Colorectal cancer , Hepatocellular carcinoma , Tumor-induced angiogenesis , With-no-lysine (K) kinase I , Zebrafish ]

Association of subcutaneous and visceral adipose tissue with overall survival in Taiwanese patients with bone metastases – results from a retrospective analysis of consecutively collected data
PLoS ONE, 15, 1, 2020-01-01

Prognostic significance of pretreatment neutrophil-to-lymphocyte ratio in older patients with metastatic cancer
Journal of Geriatric Oncology, 10, 5, 757-762, 2019-09-01

Tail shape evolution dynamics of MDCK cells on fibronectin substrates
Biomedical Physics and Engineering Express, 5, 4, 2019-05-16
[ actin filament , cell migration , cell shape evolution , focal adhesion , tail retraction , treadmilling motion ]

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
Nature Communications, 9, 1, 2018-12-01

Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation
Physical Review Letters, 121, 1, 2018-07-03

EBV oncogene N-LMP1 induces CD4 T cell-mediated angiogenic blockade in the murine tumor model
Journal of Immunology, 194, 9, 4577-4587, 2015-01-01

Role of leukemia inhibitory factor in nasopharyngeal carcinogenesis
Molecular and Cellular Oncology, 1, 1, 2014-01-01
[ Epstein-Barr virus , leukemia inhibitory factor , mTOR , nasopharyngeal carcinoma , p70S6K , radioresistance ]

Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma
Journal of Proteome Research, 13, 11, 4796-4807, 2014-01-01
[ biomarker , oral cavity squamous cell carcinoma , primary cell , saliva , secretome , thrombospondin-2 ]

Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance
Journal of Clinical Investigation, 123, 12, 5269-5283, 2013-12-02

Epstein-barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells
PLoS Pathogens, 8, 5, 2012-05-01

Neural stem cells secrete factors that promote auditory cell proliferation via a leukemia inhibitory factor signaling pathway
, 88, 15, 3308-3318, 2010-11-15
[ Cell culture , Cell proliferation , Cochlea , Cytokines , Leukemia inhibitory factor , Neural stem cell ]

Gα12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization
Cancer Research, 69, 15, 6122-6130, 2009-08-01

Temporal transcription program of recombinant Autographa californica multiple nucleopolyhedrosis virus
Journal of Virology, 80, 18, 8989-8999, 2006-09-01

A bayes regression approach to array-CGH data
Statistical Applications in Genetics and Molecular Biology, 5, 1, 2006-01-01
[ Change point problem , Comparative genomic hybridization , DNA copy number imbalance ]

Bimetallic photonanozyme catalysts for fluorometric analysis of total antioxidant capacity in human saliva
2025-01-01
[ Bimetallic nanocluster,Fluorescence assay,Oxidative stress,Photonanozyme,Reactive oxygen species,Total antioxidative capacity ]

Deciphering the Systemic Immune Responses Mediated by Radiotherapy in Stage I NPC Patients
2024-08-03
[ radiotherapy,immune,nasopharyngeal carcinoma ]

Radiotherapy-mediated immune modulatory responses in patients with stage I nasopharyngeal carcinoma
2024-05-04
[ immune response,nasopharyngeal carcinoma ]

Leukemia Inhibitory Factor Modulates Macrophage Immune Response Through YAP1 signaling in Oral Squamous Cell Carcinoma.
2023-05-06
[ LIF, leukemia inhibitory factor, macrophage, oral cancer ]

The multifaceted roles of leukemia inhibitor factor in tuning the immune microenvironment of oral squamous cell carcinoma
200, 2023-05-06
[ 頭頸癌，免疫治療，白血病抑制因子，單細胞定序，腫瘤微環境，免疫檢查點 ]

EBV positive NPC-derived exosomes promote macrophage M2 polarization via activating MST1R signaling
200, 2023-05-06
[ Epstein-Barr virus, EBV, nasopharyngeal carcinoma, NPC, exosome ]

Leukemia inhibitory factor regulates macrophage immune response in head and neck squamous cell carcinoma
2023-04-14
[ LIF, leukemia inhibitory factor, macrophage, oral cancer ]

EBV positive NPC-derived exosomes promote macrophage M2 polarization via activating MST1R and YAP1 signalings
2023-04-14
[ Epstein-Barr virus, EBV, nasopharyngeal carcinoma, exosome, macrophage ]

NPC-Derived Exosomal LMP1 Promotes Macrophage M2 Polarization Via Activating MST1R Signaling
2023-03-18
[ Epstein-Barr virus, latent membrane protein 1, exosome ]

Systemic Immune Signatures Associated with Radiation Therapy in Nasopharyngeal Carcinoma at Single-Cell Resolution.
2022-12-10
[ radiotherapy, radiation, single-cell, radioresistance ]

Leukemia Inhibitor Factor Promotes Polarization and Immune Regulations of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma
2022-04-30
[ leukemia inhibitory factor, oral cancer, tumor microenvironment, macrophage ]

Investigating the Role of NPC-Derived Exosomes in Regulating Macrophage Immunity
2022-04-30
[ exosome, macrophage, immune, nasopharyngeal carcinoma ]

Decoding the Systemic Immune Signatures Associated with Radiation Therapy in Nasopharyngeal Carcinoma
2022-04-30
[ radiation, radiotherapy, single cell sequencing, nasopharyngeal carcinoma ]

EBV-products containing exosomes remodel NPC tumor microenvironment by activating fibroblasts
Cancer Res 2022;82(12_Suppl):Abstract nr 3192., 2022-04-08
[ fibroblast, exosome, nasopharygeal carcinoma ]

Nasopharyngeal Carcinoma-Derived EBV Products-Containing Exosomes Regulate Macrophage Polarization and Immune Responses
2022-03-26
[ nasopharyngeal carcinoma, immune, macrophage ]

Investigating the NPC-derived Exosomes-Mediated Effects on Macrophage Polarization and Immune Response
2021-09-04
[ macrophage, immune response, NPC, RNA sequencing ]

EBV Product-Containing Exosomes Remodel the Tumor Microenvironment by Activating Stromal Fibroblasts
2021-09-04
[ exosome, fibroblast, EBV, NPC ]

Emerging role of exosomes in cancer: clinical insights and diagnostic potential
2021-06-05
[ exosome, cancer ]

Interactions between Epstein-Barr virus and tumor-associated adipocytes
2020-03-02
[ EBV, adipocyte, tumor microenvironment, lipid ]

Epstein-Barr virus dedifferentiates adipocytes and modulates tumor microenvironment
2019-05-04
[ EBV, fibroblast, adipocyte differentiation ]

The Molecular basis of LIF-mediated NPC metastasis
79, 2019-03-29
[ nasopharyngeal caricinoma, LIF, YAP1, focal adhesion ]

SRC-YAP1 Signaling Modulates Activation of Fibroblasts in the NPC Tumor Microenvironment
2018-06-10
[ YAP1, NPC, SRC ]