教師個人簡歷
現職
國立中央大學
生醫理工學院生醫科學與工程學系
副教授
專長
腫瘤基因體學
癌轉移及癌症生物學
轉譯醫學研究
次世代定序數據分析
Tumor genomics
cancer metastasis and cancer biology
translational medical research
next-generation sequencing data analysis
專長簡述
腫瘤基因體學、癌轉移及癌症生物學、轉譯醫學研究、次世代定序數據分析
最高學歷
國立陽明大學
藥理學研究所
博士
科技部學門領域
教育部學門領域
高教深耕計畫
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跨域智慧健康科技於USR場域之應用與實踐模式建構
1150101~1151231
-
乳癌個人化精準治療平台的創新技術開發與應用
1140901~1141231
-
跨域智慧健康科技於USR場域之應用與實踐模式建構
1140101~1141231
-
經奈米金處理後的脂肪幹細胞外泌體對對慢性膀胱炎上皮細胞之抗炎症反應探討
1140101~1141231
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乳癌個人化精準治療平台的創新技術開發與應用
1130901~1131231
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113年度教學實踐研究推動與分析計畫-許藝瓊老師
1130101~1131231
-
以系統生物學方法評估標靶奈米藥物載體於調控肝硬化中門脈壓力之機轉研究
1130101~1131231
-
評估 CyclophosphamideCyclophosphamide Cyclophosphamide誘發膀胱發炎模式中組織血管收縮素及其受體表達
1130101~1131231
[, ] -
探討泌尿道發炎病人尿液微生物相和臨床治療之關聯性分析
1110101~1111231
其他補助
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114年大專校院STEM領域及女性研發人才培育計畫-智慧生醫數據應用與女性創新人才培育計畫
1140801~1150731
[生成式AI,智慧醫療,生醫數據,實作導向學習,跨域教育,女生支持機制 , Generative AI,Smart Healthcare,Biomedical Data,Hands-on Learning,nterdisciplinary Education,Female Talent Support] -
生醫資料分析專題導向學習:連結社會實踐
1130801~1140731
[專題式學習,教學實驗,創造力,社會責任 , project-based learning,Teaching Experiment,Creativity,Social responsibility] -
人事費-博士生:生醫資料分析專題導向學習:連結社會實踐
1130801~1140731
[專題式學習,教學實驗,創造力,社會責任 , project-based learning,Teaching Experiment,Creativity,Social responsibility] -
112年大專校院STEM領域及女性研發人才培育計畫-生醫數據分析人才培育計畫
1120801~1130731
[人工智慧,大數據,生醫訊號,基因體資料,智慧醫療,精準健康 , Artificial intelligence,big data,biomedical signals,genetic data,smart health,precision health] -
2023中大太空生醫國際營隊
1120401~1121231
[太空生醫科普教育 , Kirara,JAMSS] -
111年大專校院STEM領域及女性研發人才培育計畫-生醫數據分析人才培育計畫
1110801~1120731
[人工智慧,精準健康,生醫訊號,智慧醫療,基因體資料 , Artificial intelligence,precision health,biomedical signals,smart health,genetic data]
捐(受)贈收入
-
生醫系-2023中大太空生醫國際營隊
1120101~1130731
-
生醫系-樂遊生命密碼寒假營隊
1120101~1130731
國科會計畫統計
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開發以外泌體為基礎之急性呼吸窘迫症候群創新診斷與治療平台-運用深度學習分析急性呼吸窘迫症候群引起的肺損傷和纖維化之外泌體生物標記(3/3)
1140801~1150731
-
乳房X光智慧診斷及自動報告系統之驗證及落地
1140701~1150630
-
科普活動:基因與疾病之科學教育推廣計畫
1140701~1150630
-
開發以外泌體為基礎之急性呼吸窘迫症候群創新診斷與治療平台-運用深度學習分析急性呼吸窘迫症候群引起的肺損傷和纖維化之外泌體生物標記(2/3)
1130801~1140731
[急性呼吸窘迫症候群,人工智慧,數位生物標誌,外泌體生物標誌 , adult respiratory distress syndrome,artificial intelligence,digital biomarker,exosomal biomarker] -
科普活動:基因與疾病之科學教育推廣計畫
1130701~1140630
[基因定序, 罕見疾病, 精準健康, 基因檢測,腫瘤基因體,雙語教育 , Gene sequencing, rare diseases, precision health, genetic testing, cancer genomics, bilingual education] -
科普活動:基因與疾病之科學教育推廣計畫(主題二)
1120801~1130731
[基因定序,罕見疾病,精準醫療,基因檢測,腫瘤基因體 , Gene sequencing,rare diseases,precision medicine,genetic testing,cancer genomics] -
開發以外泌體為基礎之急性呼吸窘迫症候群創新診斷與治療平台-運用深度學習分析急性呼吸窘迫症候群引起的肺損傷和纖維化之外泌體生物標記(1/3)
1120801~1130731
[急性呼吸窘迫症候群,人工智慧,數位生物標誌,外泌體生物標誌 , adult respiratory distress syndrome,artificial intelligence,digital biomarker,exosomal biomarker] -
脂肪肝演進至肝硬化之早期尿液生物標記創新檢測平台-結合醫學影像資訊與生物資訊進行脂肪肝病變生物標記篩選(子計畫二)
1110801~1120731
[脂肪肝, 深度學習, 體學, 生物標誌 , fatty liver disease, deep learning, omics, biomarker] -
結合醫學資訊與生物資訊進行糖尿病腎病變生物標誌篩選
1100801~1110731
[糖尿病腎病變,深度學習,次世代定序,生物標誌,胞外體 , Diabetic nephropathy,Deep learning,Next Generation Sequencing,biomarker,exosome] -
仿生系統效力評估於肝纖維化動物模式比較
1091101~1101031
[肝纖維化 系統生物學 週期性機械拉伸 次世代定序 , Liver fibrosis,system biology,Cyclic mechanical stretch,Next-Generation Sequencing] -
以仿生機械動態培養系統探討肺癌轉移基因
1080801~1090731
[週期性機械拉力, 肺癌轉移, 深度學習, 微流道晶片, 生物標誌 , cyclic stretch, lung cancer metastasis, deep learning, microfluidic chip, biomarker] -
以系統生物學方法探討細胞生物力學於疾病模式之應用
1071101~1081031
[週期性機械拉伸, 微陣列晶片, 蛋白質體學, 系統生物學 , Cyclic mechanical stretch, microarray, proteomics, system biology] -
以次世代定序資料探索肺癌細胞株侵襲能力相關基因 II
1070801~1080731
[胞外泌體, 轉錄體, 蛋白質體 ,次世代定序, 上皮細胞生長因子接受體 , exosome, transcriptome, proteomic, NGS, EGFR] -
以次世代定序資料探索肺癌細胞株侵襲能力相關基因
1051201~1061031
產學合作計畫統計
-
114 年中大國泰醫院聯合研發中心計畫-乳癌個人化精準治療平台的創新技術開發與應用
1140901~1150831
[次世代定序,循環腫瘤細胞 , NGS,CTC] -
奈捷生物科技股份有限公司與中央實驗室研究計畫
1140101~1151231
[基因定序 , 乳癌, 精準醫療 , gene sequence,breast cancer,precision medicine] -
吉田福興生醫有限公司與中央實驗室研究計畫
1131215~1141231
[基因定序 , gene sequence] -
113 年中大國泰醫院聯合研發中心計畫-乳癌個人化精準治療平台的創新技術開發與應用
1130901~1140831
[次世代定序,循環腫瘤細胞 , NGS,CTC] -
委託測試精子微重力影響評估分析
1130401~1140331
[太空生醫 , Space Biomedicine] -
委託測試仿生模式評估分析
1120801~1130731
[仿生模式,評估分析 , bionic mode,evaluation analysis] -
應用於石化廠交班紀錄之語音辨識軟體維護更新
1120201~1140131
[語音辨識 , speech recognition] -
吉田福興生醫與中央聯合實驗室計畫
1120101~1121231
[土壤液化監測,微生物特性,次世代定序 , Soil Liquefaction Monitoring,Microbial properties,Next Generation Sequencing] -
工程仿生組織建構用於癌症藥物治療模型評估
1110801~1120731
[細胞晶片,三維培養 , cell chip,3D culture] -
應用於石化廠交班紀錄之語音辨識軟體
1110701~1120131
[語音辨識 , voice recognition] -
生醫數據分析人才培育計畫–利用系統生物學運用人工智慧(AI)比較動態培養與動物實驗結果分析
1100101~1120731
[人工智慧,系統生物學,動態培養 , system biology,artificial intelligence,dynamic culture] -
產學合作計畫-仿生系統效力評估於肝纖維化動物模式比較
1091101~1101031
[肝纖維化 系統生物學 週期性機械拉伸 次世代定序 , Liver fibrosis,system biology,Cyclic mechanical stretch,Next-Generation Sequencing]
期刊著作
-
A systematic review of microgravity on reproductive systems: Implications for space biology and human health
iScience, 29, 2, 2026-02-20
[ reproductive medicine,space medicine ] -
Injectable Deep Eutectic Solvent-Based Ionic Gel With Rapid Gelation and Broad Hemostatic Functionality
Advanced healthcare materials, 15, 3, 2026-01-19
[ antibacterial,biocompatibility,deep eutectic solvent,hemostasis,ionic gel,tissue adhesion ] -
Characterization of the oral microbiota in zygomatic versus dental implants: Implications for full-mouth rehabilitation
Journal of Dental Sciences, 21, 1, 570-578, 2026-01-01
[ 16S rRNA sequencing,Dental implant,Maxillary sinus,Oral microbiota,Peri-implant microbiome,Zygomatic implant ] -
Identifying CSNK1E as a therapeutic target in thyroid cancer among the core circadian clock genes
Histochemistry and Cell Biology, 163, 1, 2025-12-01
[ Cell cycle,Circadian clock genes,CSNK1E,Epithelial-mesenchymal transition,Thyroid cancer ] -
Decellularized porcine urinary bladder matrix as a dynamic biomaterial scaffold for myocardial cell adhesion
Journal of the Taiwan Institute of Chemical Engineers, 176, 2025-11-01
[ Calcium ion signaling,Decellularized scaffold,Dynamic culture,Myocardial cell adhesion ] -
A TIMELESS link to dedifferentiation in thyroid cancer
Journal of Endocrinology, 267, 1, 2025-10-01
[ cell cycle,dedifferentiation,thyroid cancer,TIMELESS ] -
Immune Evasion in Head and Neck Squamous Cell Carcinoma: Roles of Cancer-Associated Fibroblasts, Immune Checkpoints, and TP53 Mutations in the Tumor Microenvironment
Cancers, 17, 15, 2025-08-01
[ cancer-associated fibroblasts,CTLA-4,head and neck squamous cell carcinoma,immune evasion,immunotherapy,myeloid-derived suppressor cells,natural killer cells,PD-1/PD-L1,regulatory T cells,tumor microenvironment ] -
Response to comment on “Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer”
Journal of the Formosan Medical Association, 124, 5, 2025-05-01 -
Overexpression of NR1D1 Portends Disease Recurrence in Thyroid Cancer
Journal of Clinical Endocrinology and Metabolism, 110, 4, 991-1002, 2025-04-01
[ cell adhesion,NR1D1,recurrence,thyroid cancer,β-catenin ] -
Effect of Genetic Ancestry on Phenotypes and Genotypes in Papillary Thyroid Cancer
OMICS A Journal of Integrative Biology, 29, 4, 117-124, 2025-04-01
[ genetic ancestry,papillary thyroid cancer,political determinants of health,principal component analysis,public health,weighted gene co-expression network analysis ] -
Drug Resistance in Late-Stage Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer Patients After First-Line Treatment with Tyrosine Kinase Inhibitors
International Journal of Molecular Sciences, 26, 5, 2025-03-01
[ epidermal growth factor receptor (EGFR),next-generation sequencing (NGS),non-small cell lung cancer (NSCLC),tyrosine kinase inhibitors (TKIs) ] -
Areca catechu L. Extract Inhibits Colorectal Cancer Tumor Growth by Modulating Cell Apoptosis and Autophagy
Current Issues in Molecular Biology, 47, 2, 2025-02-01
[ apoptosis,Areca catechuL,autophagy,colorectal cancer,MAPK pathway,PI3K/AKT pathway ] -
Glucose Transporter 1 Inhibitors Induce Autophagy and Synergize With Lenvatinib in Thyroid Cancer Cells
Head and Neck, 47, 2, 615-624, 2025-02-01
[ autophagy,GLUT1,lenvatinib,synergy,thyroid cancer ] -
Dextrose Prolotherapy's Impact on the Urinary Microbiome in Interstitial Cystitis/Bladder Pain Syndrome
International Journal of Medical Sciences, 22, 7, 1516-1527, 2025-01-01
[ 16S sequencing,bladder pain syndrome,interstitial cystitis,microbiome,urinary microbiome ] -
Nocturnal sentry duty and cardiometabolic characteristics in armed forces personnel
World Journal of Cardiology, 16, 12, 751-759, 2024-12-26
[ Armed forces personnel,Cardio-metabolic characteristics,Night sentry duty,Partial sleep deprivation ] -
Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer
Journal of the Formosan Medical Association, 123, 8, 830-836, 2024-08-01
[ Adjuvant treatment,Chemotherapy,Chinese herbal medicine,Flavonoid,Oral cancer ] -
Select gene mutations associated with survival outcomes in ER-positive ERBB2-negative early-stage invasive breast cancer: A single-institutional tissue bank study
Cancer Medicine, 13, 14, 2024-07-01
[ ER+/HER2-,multigene mutational panel,prognostication,relapse-free survival,targeted sequencing,tissue bank ] -
Serum Malondialdehyde-Modified Low-Density Lipoprotein as a Risk Marker for Peripheral Arterial Stiffness in Maintenance Hemodialysis Patients
Medicina, 60, 5, 2024-05-01
[ cardiovascular disease,end-stage renal disease,hemodialysis,malondialdehyde-modified low-density lipoprotein,peripheral arterial stiffness,pulse wave velocity ] -
An ecological analysis of associations between ambient air pollution and cancer incidence rates in Taiwan
Environmental Science and Pollution Research, 31, 20, 29162-29173, 2024-04-01
[ Air pollution,Colorectal cancer,Incidence,Liver cancer,Particulate matter,Thyroid cancer,Weighted quantile sum ] -
Population-based analysis of the human development index and risk factors for head and neck cancer
Head and Neck, 46, 4, 889-895, 2024-04-01
[ epidemiology,head and neck cancer,human development index,incidence,risk factor ] -
Role of Epstein-Barr Virus in Breast Cancer: Correlation with Clinical Outcome and Survival Analysis
Journal of Cancer, 15, 8, 2403-2411, 2024-01-01
[ breast cancer,Epstein-Barr virus,recurrence,survival,Taqman qPCR ] -
Evaluation of Pm2.5 Influence on Human Lung Cancer Cells Using a Microfluidic Platform
International Journal of Medical Sciences, 21, 6, 1117-1128, 2024-01-01
[ invasion,Lung cancer,migration,mitochondrial dysfunction,PM2.5,ROS ] -
Substance use and incidence of metabolic syndrome before midlife among military adults: the CHIEF cohort study
Frontiers in Public Health, 12, 2024-01-01
[ cohort study,metabolic syndrome,military personnel,physical activity,substance use ] -
SOX4 is a pivotal regulator of tumorigenesis in differentiated thyroid cancer
Molecular and Cellular Endocrinology, 578, 2023-12-01
[ CRABP2,SOX4,Thyroid cancer,Tumorigenesis ] -
Whole exome sequencing and MicroRNA profiling of lung adenocarcinoma identified risk prediction features for tumors at stage I and its substages
Lung Cancer, 184, 2023-10-01
[ MicroRNA expression,Relapse risk prediction,Somatic mutation,Stage I lung adenocarcinomas ] -
Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer
Endocrine, 81, 3, 513-520, 2023-09-01
[ DCSTAMP,Immunohistochemistry,Recurrence,Survival,Thyroid cancer ] -
Mechanical Stretch Promotes Invasion of Lung Cancer Cells via Activation of Tumor Necrosis Factor-alpha
Biotechnology and Bioprocess Engineering, 28, 3, 467-472, 2023-06-01
[ invasion,lung cancer,mechanical stretch,microarray ] -
Trends in thyroid cancer burden in Taiwan over two decades
Cancer Causes and Control, 34, 6, 553-561, 2023-06-01
[ Incidence,Taiwan,Thyroid cancer,Time trends ] -
Anti-Aliasing Attention U-net Model for Skin Lesion Segmentation
Diagnostics, 13, 8, 2023-04-01
[ computer-aided diagnosis,deep learning,light-weight model,medical internet of things,skin lesion segmentation ] -
The COVIDTW study: Clinical predictors of COVID-19 mortality and a novel AI prognostic model using chest X-ray
Journal of the Formosan Medical Association, 122, 3, 267-275, 2023-03-01
[ Artificial intelligence,Chest X-rays,COVID-19,Intensive care unit,Mortality,Prognosis ] -
Electrocardiographic and echocardiographic predictors of greater carotid intima-media thickness in tactical athletes: The CHIEF atherosclerosis study
Annals of Noninvasive Electrocardiology, 28, 2, 2023-03-01
[ carotid intima-media thickness,echocardiography,electrocardiography,military personnel,tactical athletes ] -
Electrocardiogram Heartbeat Classification for Arrhythmias and Myocardial Infarction
Sensors, 23, 6, 2023-03-01
[ deep learning,electrocardiogram (ECG) classification,MIT-BIH dataset,PTB dataset ] -
Videofluoroscopy dysphagia severity scale is predictive of subsequent remote pneumonia in dysphagia patients
International Journal of Medical Sciences, 20, 3, 429-436, 2023-01-01
[ dysphagia,Dysphagia Severity Scale,pneumonia,videofluoroscopy ] -
Downregulation of cellular retinoic acid binding protein 1 fosters epithelial–mesenchymal transition in thyroid cancer
Molecular Carcinogenesis, 2023-01-01
[ CRABP1,epidermal growth factor signaling,epithelial–mesenchymal transition,thyroid cancer ] -
Synthesis, characterization, and biological verification of asialoglycoprotein receptor-targeted lipopolysaccharide-encapsulated PLGA nanoparticles for the establishment of a liver fibrosis animal model
Biomaterials Science, 2023-01-01
[ nanoparticles,liver fibrosis ] -
Insulin Resistance Indices and Carotid Intima-media Thickness in Physically Fit Adults: CHIEF Atherosclerosis Study
Endocrine, Metabolic and Immune Disorders - Drug Targets, 23, 11, 1442-1448, 2023-01-01
[ Carotid intima-media thickness,insulin resistance,METS-IR,TG/HDL-C ratio,TyG index,young adults ] -
Role of the gut microbiota and their metabolites in hemodialysis patients
International Journal of Medical Sciences, 20, 6, 725-736, 2023-01-01
[ calcium-phosphorus product,chronic kidney disease,dysbiosis,gut microbiota ] -
Impact of social and economic factors on global thyroid cancer incidence and mortality
European Archives of Oto-Rhino-Laryngology, 2023-01-01
[ Fine particulate matter,Human development index,Mortality-to-incidence ratio,Thyroid cancer ] -
CRABP2 Is Associated with Thyroid Cancer Recurrence and Promotes Invasion via the Integrin/FAK/AKT Pathway
Endocrinology, 163, 12, 2022-12-01
[ cellular retinoic acid-binding protein 2,epithelial-mesenchymal transition,integrin,thyroid cancer ] -
Enhanced angiogenic potential of adipose-derived stem cell sheets by integration with cell spheroids of the same source
Stem Cell Research and Therapy, 13, 1, 2022-12-01
[ 3d culture, stem cell ] -
Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration
Frontiers in Oncology, 12, 2022-08-02
[ FAK,inhibitor of DNA binding protein 2,lung adenocarcinoma,metastasis,twist ] -
Association of Pathway Mutations With Survival in Taiwanese Breast Cancers
Frontiers in Oncology, 12, 2022-07-22
[ breast cancer,cancer panel,next-generation sequencing,survival analysis,triple negative ] -
Transcriptomic Characteristics Associated With Aging in the Thyroid Gland
Frontiers in Nutrition, 9, 2022-05-25
[ aging,cytoskeletal proteins,immune response,mitochondria,thyroid gland ] -
A nanofluidic preconcentrator integrated with an aluminum-based nanoplasmonic sensor for Epstein-Barr virus detection
Sensors and Actuators, B: Chemical, 355, 2022-03-15 -
Convolutional Blur Attention Network for Cell Nuclei Segmentation
Sensors, 22, 4, 2022-02-01
[ Cell nuclei,Convolutional neural network,Deep learning,Nucleus segmentation ] -
Antialiasing Attention Spatial Convolution Model for Skin Lesion Segmentation with Applications in the Medical IoT
Wireless Communications and Mobile Computing, 2022, 2022-01-01 -
SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway
Endocrine-Related Cancer, 29, 2, 47-58, 2021-12-13
[ invasion,lipid metabolism,SREBP1,thyroid cancer ] -
The Prognostic Significance of PD1 and PDL1 Gene Expression in Lung Cancer: A Meta-Analysis
Frontiers in Oncology, 11, 2021-11-18
[ biomarker,immune checkpoint,lung cancer,microarray,survival analysis ] -
A potential microbiological approach to the evaluation of earthquake-induced soil liquefaction
iScience, 24, 9, 2021-09-24
[ Biogeochemistry,Earth sciences,Microbiology,Seismology,Soil science ] -
Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia
Frontiers in Oncology, 11, 2021-09-13
[ biomarker,blood test,colorectal cancer,proteome,small extracellular vesicle ] -
Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells
International Journal of Endocrinology, 2021, 2021-01-01 -
Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
Evidence-based Complementary and Alternative Medicine, 2021, 2021-01-01 -
CCL2 associated with CD38 expression during ex vivo expansion in human cord blood-derived hematopoietic stem cells
Aging, 13, 15, 19878-19893, 2021-01-01
[ CD38,cord blood,hematopoietic stem cells,inflammation,microarray ] -
The built study: A single-center 5-year experience of lung cancer screening in Taiwan
International Journal of Medical Sciences, 18, 16, 3861-3869, 2021-01-01
[ Low dose CT,Lung cancer,Pulmonary nodule,Screening ] -
Combination of peroxisome proliferator–activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells
Journal of the Chinese Medical Association, 83, 10, 923-930, 2020-10-01
[ Peroxisome proliferator–activated receptor gamma,Retinoid X receptor,Sodium/iodide symporter,Thyroid cancer ] -
Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology
Aging, 12, 16, 16035-16045, 2020-08-31
[ Cardiac cell,Cyclic stretching,Functional enrichment,Next-generation sequencing ] -
Landscape of mitochondria genome and clinical outcomes in stage 1 lung adenocarcinoma
Cancers, 12, 3, 2020-03-01
[ EGFR-activating mutations , Lung adenocarcinoma , Mitochondria , Prognosis , Somatic mutations ] -
Hydroxygenkwanin suppresses non-small cell lung cancer progression by enhancing EGFR degradation
Molecules, 25, 4, 2020-02-19
[ Apoptosis , Daphne genkwa , EGFR , Hydroxygenkwanin , NSCLC ] -
Targeting the pentose phosphate pathway increases reactive oxygen species and induces apoptosis in thyroid cancer cells
Molecular and Cellular Endocrinology, 499, 2020-01-01
[ Apoptosis , Pentose phosphate pathway , Reactive oxygen species , Thyroid cancer ] -
Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells
OncoImmunology, 9, 1, 2020-01-01
[ Cancer stem cell,CD47,ovarian cancer,tumor microenvironment ] -
Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies
Nature Nanotechnology, 14, 12, 1160-1169, 2019-12-01 -
Is papillary thyroid microcarcinoma a biologically different disease? A propensity score-matched analysis
Journal of Surgical Oncology, 120, 6, 1023-1030, 2019-11-01 -
Anticancer Effect and Mechanism of Hydroxygenkwanin in Oral Squamous Cell Carcinoma
Frontiers in Oncology, 9, 2019-09-18
[ apoptosis , cell cycle , invasion , migration , oral cancer , RNA sequencing ] -
A Novel Prediction Model for Bloodstream Infections in Hepatobiliary–Pancreatic Surgery Patients
World Journal of Surgery, 43, 5, 1294-1302, 2019-05-15 -
Tumor mutation burden and recurrent tumors in hereditary lung cancer
Cancer Medicine, 8, 5, 2179-2187, 2019-05-01
[ hereditary lung cancer , mutation load , nonsmoker , recurrence , whole genome sequencing ] -
Genome-wide scan for copy number alteration association with relapse-free survival in colorectal cancer with liver metastasis patients
Journal of Clinical medicine, 7, 11, 2018-11-18 -
Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation
Head and Neck, 40, 11, 2528-2537, 2018-11-01 -
Heme oxygenase-1 inhibitors induce cell cycle arrest and suppress tumor growth in thyroid cancer cells
International Journal of Molecular Sciences, 19, 9, 2018-09-01
[ Heme oxygenase , Metabolism , Reactive oxygen species , Thyroid cancer ] -
FAM198B is associated with prolonged survival and inhibits metastasis in lung adenocarcinoma via blockage of ERK-Mediated MMP-1 expression
Clinical Cancer Research, 24, 4, 916-926, 2018-02-15 -
Comparison of topical mupirocin and gentamicin in the prevention of peritoneal dialysis-related infections: A systematic review and meta-analysis
American Journal of Surgery, 215, 1, 179-185, 2018-01-01 -
Dipeptidyl peptidase IV as a prognostic marker and therapeutic target in papillary thyroid carcinoma
Journal of Clinical Endocrinology and Metabolism, 102, 8, 2930-2940, 2017-08-01 -
Recurrence-associated genes in papillary thyroid cancer: An analysis of data from The Cancer Genome Atlas
Surgery, 161, 6, 1642-1650, 2017-06-01 -
Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer
, 40, 12, 2922-2929, 2016-12-01 -
Molecular gene signature and prognosis of non-small cell lung cancer
, 7, 32, 51898-51907, 2016-08-01
[ Gene signature , Non-small cell lung cancer , Prognosis , Risk score , TaqMan Low-Density Array ] -
1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane potentiates in vitro and in vivo antitumor effects of irinotecan on human colorectal cancer cells
Oncology Letters, 11, 5, 3551-3557, 2016-05-01
[ 1,6-bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane (DPD) , Apoptosis , COLO 205 , Colorectal cancer , Irinotecan , Microarray , NCI-60 , Pharmacokinetics ] -
EPIANNO: EPIgenomics ANNOtation tool
PLoS ONE, 11, 2, 2016-02-01 -
SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma
, 7, 28, 44417-44429, 2016-01-01
[ AP-1 , E-cadherin , Metastasis , SLUG , SPANX family ] -
Oncogenic miR-137 contributes to cisplatin resistance via repressing CASP3 in lung adenocarcinoma
American Journal of Cancer Research, 6, 6, 1317-1330, 2016-01-01
[ Caspase 3 , Chemoresistance , Cisplatin , Lung adenocarcinoma , MiR-137 ] -
Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane
International Journal of Clinical and Experimental Medicine, 8, 9, 14805-14815, 2015-09-30
[ Cell cycle , DPA , HCT-116 , P21 , P53 , Pharmacokinetics ] -
EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway
Scientific Reports, 5, 2015-09-04 -
R331W missense mutation of oncogene YAP1 is a germline risk allele for lung adenocarcinoma with medical actionability
Journal of Clinical Oncology, 33, 20, 2303-2310, 2015-07-10 -
CD74 expression and its therapeutic potential in thyroid carcinoma
Endocrine-Related Cancer, 22, 2, 179-190, 2015-04-01
[ Antibody , CD74 , Macrophage migration inhibitory factor , Thyroid cancer ] -
Slug is temporally regulated by cyclin e in cell cycle and controls genome stability
Oncogene, 34, 9, 1116-1125, 2015-02-26 -
Quality of Life after Surgery or Surveillance for Asymptomatic Primary Hyperparathyroidism: A Meta-Analysis of Randomized Controlled Trials
Medicine (United States), 94, 23, 2015-01-01 -
Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate concentrations in U.S. adults: The national health and nutrition examination survey 2005-2006
PLoS ONE, 9, 12, 2014-12-16 -
Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway
PLoS ONE, 9, 2, 2014-02-21 -
Association between parathyroid hormone levels and inflammatory markers among US adults
Mediators of Inflammation, 2014, 2014-01-01 -
Significance of Allelic Percentage of BRAF c.1799T > A (V600E) Mutation in Papillary Thyroid Carcinoma
, 21, 4, 619-626, 2014-01-01 -
The Motor Protein KIF14 Inhibits Tumor Growth and Cancer Metastasis in Lung Adenocarcinoma
PLoS ONE, 8, 4, 2013-04-23 -
Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity
BMC Medicine, 11, 1, 2013-04-16
[ Chemotherapy , Invasion , Metastasis , Microarray , NCI-60 ] -
Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer
, 107, 5, 493-497, 2013-04-01
[ inflammation , neutrophil-to-lymphocyte ratio , thyroid cancer ] -
α-catulin drives metastasis by activating ILK and driving an αvβ3 integrin signaling axis
Cancer Research, 73, 1, 428-438, 2013-01-01 -
Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma
Cell Biochemistry and Biophysics, 65, 2, 203-210, 2013-01-01
[ Adiponectin , Adiponectin receptor , Leptin , Obesity , Thyroid cancer ] -
Regulation of leptin receptor expression in human papillary thyroid cancer cells
, 66, 6, 469-473, 2012-09-01
[ Epigenetic regulation , Insulin , Leptin receptor ] -
Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells
Oncology Reports, 27, 2, 529-534, 2012-02-01
[ Anti-migration , Anti-proliferation , Cell cycle , Colorectal carcinoma , Diamantane , p21 ] -
Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways
Oncology Reports, 26, 5, 1265-1271, 2011-11-01
[ Cell migration , Leptin , MAPK , PI3K/AKT , Thyroid cancer ] -
Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations
Journal of Clinical Oncology, 29, 25, 3435-3442, 2011-09-01 -
A four-gene signature from NCI-60 cell line for survival prediction in non-small cell lung cancer
Clinical Cancer Research, 15, 23, 7309-7315, 2009-12-01 -
Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells
Nutrition and Cancer, 61, 5, 735-745, 2009-09-01 -
Mitochondria are an essential mediator of nitric oxide/cyclic guanosine 3′,5′-monophosphate blockingof glucose depletion-induced cytotoxicity in human HepG2 cells
Molecular Cancer Research, 5, 9, 923-932, 2007-09-01
研討會著作
-
ASTROREPOMICS – Integrated Transcriptomic Database for Space Reproductive Studies
2025-05-28
[ microgravity ] -
The Exploration of a Bioreactor that Combines Stretching and Electrical Stimulation for Cardiomyocytes
2025-04-10
[ Electrical Stimulation ] -
Automated Cancer Classification in Tissue Microarray Images Using EfficientNetB5 and Advanced Data Augmentation Techniques
2025-01-12
[ tissue array ] -
Systems Biology Approach to Investigating the Impactof ExosomalmiRNA and Proteins on Gefitinib Resistance in Lung Adenocarcinoma
2024-11-22
[ exosome ,cancer ] -
In Vitro Bionic Heart Failure 3D Model Research
2024-11-09
[ 多體學 精準醫療 ] -
A Machine Learning Approach: Early Detection of Diabetic Nephropathy Based on Laboratory Tests
2023-06-30
[ diabetic nephropathy,early detection,machine learning,laboratory tests ] -
Exploring Mechanisms of Gefitinib Resistance in Lung Adenocarcinoma using Systems Biology Approach
2023-05-06
[ gefitinib resistance,lung adenocarcinoma,exosomes,miRNAs,IGF2 ] -
Systems Biology Approaches to Explore Lung Adenocarcinoma Resistant to Gefitinib
2023-03-31
[ adenocarcinoma,exosomes,gefitinib,miRNAs,IGF2 ] -
The Impact of Gut Microbiota and Metabolites on Vascular Calcification in Hemodialysis Patients: An Association Analysis
2022-12-18
[ gut microbiota,vascular calcification,metabolites,hemodialysis,chronic kidney disease (CKD) ] -
Mechanical stretch promotes invasion of lung cancer cells via activation of tumor necrosis factor-alpha
2022-12-18
[ Mechanical stretch, lung cancer cells, tumor necrosis factor-alpha ] -
Omics-based human liver 3D dynamic platforms
2022-11-19
[ Omics-based human liver 3D dynamic platforms ] -
Association analysis between gut microbiota and their metabolites toward vascular calcification in hemodialysis patients
2022-11-19
[ gut microbiota,vascular calcification,metabolites,hemodialysis,chronic kidney disease (CKD) ] -
THE COVIDTW STUDY: CLINICAL PREDICTORS OF COVID-19 MORTALITY AND A NOVEL AI PROGNOSTIC MODEL BASED ON CHEST X-RAY
2022-09-19
[ COVID-19, CHEST X-RAY, A NOVEL AI PROGNOSTIC MODEL, CLINICAL PREDICTORS OF COVID-19 MORTALITY ] -
The effect of cyclic mechanical stretch on the 3D culture model of lung cancer cells
2022-04-16
[ 3d culture, lung cancer, invasion ] -
Transcriptomics research of Niemann-Pick disease
2022-04-16
[ NPC, RNAseq ] -
Deep learning-based lung cancer survival prognosis from multiple omics data
2022-03-12
[ omics, lung cancer ] -
Modified Attention Spatial Convolution Model for Skin Lesion Segmentation
2021-01-01
校外榮譽
- 113 [高雄榮民總醫院] 第20屆(2024)榮總台灣聯合大學合作研究計畫優良論文獎第一名
- 113 [經濟部] 2024台灣創新技術博覽會 銅牌
- 111 [經濟部] 2022台灣創新技術博覽會 銅牌
- 110 [經濟部] 2021台灣創新技術博覽會 銅牌
- 109 [科技部] 科技部工程司109年度產學合作計畫成果優良獎
- 108 [經濟部] 2019台灣創新技術博覽會 金牌
校內獲獎
- 115 研究傑出獎
- 114 研究傑出獎
- 113 研究傑出獎
- 112 研究傑出獎
- 111 研究傑出獎
- 107 新聘傑出獎(舊制)
- 106 新進教師補助
- 106 新聘傑出獎(舊制)
- 105 新聘傑出獎(舊制)
期刊編輯
-
111 ~ 112
Biomedicines
EISSN 2227-9059
儘管靶向治療取得了成功,但肺癌在全球癌症中的死亡率最高。為了大幅降低肺癌死亡率,採取實質性全球行動以及在預防、早期發現和治療這種疾病方面十分重要。肺癌是一種複雜的基因疾病,由個體一生中基因組中積累的體細胞突變驅動。此外,雖然 TKI 治療對 EGFR 突變的患者有效,但在幾個月內就會出現抗藥性。因此,對 EGFR TKI 獲得抗藥性的新機制將為肺癌提供新的治療靶點。對 EGFR TKI 耐藥機制的深入理解強調了基因型指導治療方法的重要性。改善疾病管理的其他關鍵方麵包括開發新的治療方法和提供肺癌的分子機制。新型分子生物標誌物和治療機會的開發代表了肺癌的新治療策略。本期我們將重點探討肺癌治療的新藥新方法。
- 建立組織微陣列影像模型以及使用該模型判定組織型態的方法 [中華民國]
- 識別荷爾蒙受體狀態的方法及系統 [日本]
- 建立用於預測罹患糖尿病腎病變風險之模型以及基於模型預測糖尿病腎病變的方法 [中華民國]
- 識別荷爾蒙受體狀態的方法及系統 [中華民國]
- 藉由乳房X光攝影影像運用機器學習進行自動偵測乳癌病灶之方法 [中華民國]
- 一種以微生物特性為基礎的土壤液化之監測方法 [中華民國]
- 訓練類神經網路以預測個體基因表現特徵的方法及系統/ METHODS FOR TRAINING AN ARTIFICIAL NEURAL NETWORK TO PREDICT WHETHER A SUBJECT WILL EXHIBIT A CHARACTERISTIC GENE EXPRESSION AND SYSTEMS FOR EXECUTING THE SAME [中華民國]
- 一種用以評估大腸直腸癌肝轉移病患之預後的方法 METHOD OF MAKING A PROGNOSIS FOR PATIENT SUFFERING FROM COLORECTAL CANCER WITH LIVER METASTASIS [中華民國]
國立中央大學