期刊著作

• Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer
  Journal of the Formosan Medical Association, 123, 8, 830-836, 2024-08-01
  [ Adjuvant treatment,Chemotherapy,Chinese herbal medicine,Flavonoid,Oral cancer ]

• Select gene mutations associated with survival outcomes in ER-positive ERBB2-negative early-stage invasive breast cancer: A single-institutional tissue bank study
  Cancer Medicine, 13, 14, 2024-07-01
  [ ER+/HER2-,multigene mutational panel,prognostication,relapse-free survival,targeted sequencing,tissue bank ]

• Serum Malondialdehyde-Modified Low-Density Lipoprotein as a Risk Marker for Peripheral Arterial Stiffness in Maintenance Hemodialysis Patients
  Medicina, 60, 5, 2024-05-01
  [ cardiovascular disease,end-stage renal disease,hemodialysis,malondialdehyde-modified low-density lipoprotein,peripheral arterial stiffness,pulse wave velocity ]

• Population-based analysis of the human development index and risk factors for head and neck cancer
  Head and Neck, 46, 4, 889-895, 2024-04-01
  [ epidemiology,head and neck cancer,human development index,incidence,risk factor ]

• An ecological analysis of associations between ambient air pollution and cancer incidence rates in Taiwan
  Environmental Science and Pollution Research, 31, 20, 29162-29173, 2024-04-01
  [ Air pollution,Colorectal cancer,Incidence,Liver cancer,Particulate matter,Thyroid cancer,Weighted quantile sum ]

• Evaluation of Pm2.5 Influence on Human Lung Cancer Cells Using a Microfluidic Platform
  International Journal of Medical Sciences, 21, 6, 1117-1128, 2024-01-01
  [ invasion,Lung cancer,migration,mitochondrial dysfunction,PM2.5,ROS ]

• Role of Epstein-Barr Virus in Breast Cancer: Correlation with Clinical Outcome and Survival Analysis
  Journal of Cancer, 15, 8, 2403-2411, 2024-01-01
  [ breast cancer,Epstein-Barr virus,recurrence,survival,Taqman qPCR ]

• Substance use and incidence of metabolic syndrome before midlife among military adults: the CHIEF cohort study
  Frontiers in Public Health, 12, 2024-01-01
  [ cohort study,metabolic syndrome,military personnel,physical activity,substance use ]

• SOX4 is a pivotal regulator of tumorigenesis in differentiated thyroid cancer
  Molecular and Cellular Endocrinology, 578, 2023-12-01
  [ CRABP2,SOX4,Thyroid cancer,Tumorigenesis ]

• Chinese herbal medicine compound of Flavonoids adjunctive treatment for oral cancer
  Journal of the Formosan Medical Association, 2023-10-14
  [ Oral cancer、chemotherapy、Chinese herbal medicine、flavonoid、adjuvant treatment ]

• Whole exome sequencing and MicroRNA profiling of lung adenocarcinoma identified risk prediction features for tumors at stage I and its substages
  Lung Cancer, 184, 2023-10-01
  [ MicroRNA expression,Relapse risk prediction,Somatic mutation,Stage I lung adenocarcinomas ]

• Upregulation of dendrocyte-expressed seven transmembrane protein is associated with unfavorable outcomes in differentiated thyroid cancer
  Endocrine, 81, 3, 513-520, 2023-09-01
  [ DCSTAMP,Immunohistochemistry,Recurrence,Survival,Thyroid cancer ]

• Mechanical Stretch Promotes Invasion of Lung Cancer Cells via Activation of Tumor Necrosis Factor-alpha
  Biotechnology and Bioprocess Engineering, 28, 3, 467-472, 2023-06-01
  [ invasion,lung cancer,mechanical stretch,microarray ]

• Trends in thyroid cancer burden in Taiwan over two decades
  Cancer Causes and Control, 34, 6, 553-561, 2023-06-01
  [ Incidence,Taiwan,Thyroid cancer,Time trends ]

• Anti-Aliasing Attention U-net Model for Skin Lesion Segmentation
  Diagnostics, 13, 8, 2023-04-01
  [ computer-aided diagnosis,deep learning,light-weight model,medical internet of things,skin lesion segmentation ]

• The COVIDTW study: Clinical predictors of COVID-19 mortality and a novel AI prognostic model using chest X-ray
  Journal of the Formosan Medical Association, 122, 3, 267-275, 2023-03-01
  [ Artificial intelligence,Chest X-rays,COVID-19,Intensive care unit,Mortality,Prognosis ]

• Electrocardiographic and echocardiographic predictors of greater carotid intima-media thickness in tactical athletes: The CHIEF atherosclerosis study
  Annals of Noninvasive Electrocardiology, 28, 2, 2023-03-01
  [ carotid intima-media thickness,echocardiography,electrocardiography,military personnel,tactical athletes ]

• Electrocardiogram Heartbeat Classification for Arrhythmias and Myocardial Infarction
  Sensors, 23, 6, 2023-03-01
  [ deep learning,electrocardiogram (ECG) classification,MIT-BIH dataset,PTB dataset ]

• Videofluoroscopy dysphagia severity scale is predictive of subsequent remote pneumonia in dysphagia patients
  International Journal of Medical Sciences, 20, 3, 429-436, 2023-01-01
  [ dysphagia,Dysphagia Severity Scale,pneumonia,videofluoroscopy ]

• Insulin Resistance Indices and Carotid Intima-media Thickness in Physically Fit Adults: CHIEF Atherosclerosis Study
  Endocrine, Metabolic and Immune Disorders - Drug Targets, 23, 11, 1442-1448, 2023-01-01
  [ Carotid intima-media thickness,insulin resistance,METS-IR,TG/HDL-C ratio,TyG index,young adults ]

• Downregulation of cellular retinoic acid binding protein 1 fosters epithelial–mesenchymal transition in thyroid cancer
  Molecular Carcinogenesis, 2023-01-01
  [ CRABP1,epidermal growth factor signaling,epithelial–mesenchymal transition,thyroid cancer ]

• Synthesis, characterization, and biological verification of asialoglycoprotein receptor-targeted lipopolysaccharide-encapsulated PLGA nanoparticles for the establishment of a liver fibrosis animal model
  Biomaterials Science, 2023-01-01
  [ nanoparticles,liver fibrosis ]

• Role of the gut microbiota and their metabolites in hemodialysis patients
  International Journal of Medical Sciences, 20, 6, 725-736, 2023-01-01
  [ calcium-phosphorus product,chronic kidney disease,dysbiosis,gut microbiota ]

• Impact of social and economic factors on global thyroid cancer incidence and mortality
  European Archives of Oto-Rhino-Laryngology, 2023-01-01
  [ Fine particulate matter,Human development index,Mortality-to-incidence ratio,Thyroid cancer ]

• CRABP2 Is Associated with Thyroid Cancer Recurrence and Promotes Invasion via the Integrin/FAK/AKT Pathway
  Endocrinology, 163, 12, 2022-12-01
  [ cellular retinoic acid-binding protein 2,epithelial-mesenchymal transition,integrin,thyroid cancer ]

• Enhanced angiogenic potential of adipose-derived stem cell sheets by integration with cell spheroids of the same source
  Stem Cell Research and Therapy, 13, 1, 2022-12-01
  [ 3d culture, stem cell ]

• Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration
  Frontiers in Oncology, 12, 2022-08-02
  [ FAK,inhibitor of DNA binding protein 2,lung adenocarcinoma,metastasis,twist ]

• Association of Pathway Mutations With Survival in Taiwanese Breast Cancers
  Frontiers in Oncology, 12, 2022-07-22
  [ breast cancer,cancer panel,next-generation sequencing,survival analysis,triple negative ]

• Transcriptomic Characteristics Associated With Aging in the Thyroid Gland
  Frontiers in Nutrition, 9, 2022-05-25
  [ aging,cytoskeletal proteins,immune response,mitochondria,thyroid gland ]

• A nanofluidic preconcentrator integrated with an aluminum-based nanoplasmonic sensor for Epstein-Barr virus detection
  Sensors and Actuators, B: Chemical, 355, 2022-03-15

• Convolutional Blur Attention Network for Cell Nuclei Segmentation
  Sensors, 22, 4, 2022-02-01
  [ Cell nuclei,Convolutional neural network,Deep learning,Nucleus segmentation ]

• Antialiasing Attention Spatial Convolution Model for Skin Lesion Segmentation with Applications in the Medical IoT
  Wireless Communications and Mobile Computing, 2022, 2022-01-01

• SREBP1 promotes invasive phenotypes by upregulating CYR61/CTGF via the Hippo-YAP pathway
  Endocrine-Related Cancer, 29, 2, 47-58, 2021-12-13
  [ invasion,lipid metabolism,SREBP1,thyroid cancer ]

• The Prognostic Significance of PD1 and PDL1 Gene Expression in Lung Cancer: A Meta-Analysis
  Frontiers in Oncology, 11, 2021-11-18
  [ biomarker,immune checkpoint,lung cancer,microarray,survival analysis ]

• A potential microbiological approach to the evaluation of earthquake-induced soil liquefaction
  iScience, 24, 9, 2021-09-24
  [ Biogeochemistry,Earth sciences,Microbiology,Seismology,Soil science ]

• Exploration of the Proteomic Landscape of Small Extracellular Vesicles in Serum as Biomarkers for Early Detection of Colorectal Neoplasia
  Frontiers in Oncology, 11, 2021-09-13
  [ biomarker,blood test,colorectal cancer,proteome,small extracellular vesicle ]

• Galectin-3 Inhibitors Suppress Anoikis Resistance and Invasive Capacity in Thyroid Cancer Cells
  International Journal of Endocrinology, 2021, 2021-01-01

• Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
  Evidence-based Complementary and Alternative Medicine, 2021, 2021-01-01

• CCL2 associated with CD38 expression during ex vivo expansion in human cord blood-derived hematopoietic stem cells
  Aging, 13, 15, 19878-19893, 2021-01-01
  [ CD38,cord blood,hematopoietic stem cells,inflammation,microarray ]

• The built study: A single-center 5-year experience of lung cancer screening in Taiwan
  International Journal of Medical Sciences, 18, 16, 3861-3869, 2021-01-01
  [ Low dose CT,Lung cancer,Pulmonary nodule,Screening ]

• Combination of peroxisome proliferator–activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells
  Journal of the Chinese Medical Association, 83, 10, 923-930, 2020-10-01
  [ Peroxisome proliferator–activated receptor gamma,Retinoid X receptor,Sodium/iodide symporter,Thyroid cancer ]

• Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology
  Aging, 12, 16, 16035-16045, 2020-08-31
  [ Cardiac cell,Cyclic stretching,Functional enrichment,Next-generation sequencing ]

• Landscape of mitochondria genome and clinical outcomes in stage 1 lung adenocarcinoma
  Cancers, 12, 3, 2020-03-01
  [ EGFR-activating mutations , Lung adenocarcinoma , Mitochondria , Prognosis , Somatic mutations ]

• Hydroxygenkwanin suppresses non-small cell lung cancer progression by enhancing EGFR degradation
  Molecules, 25, 4, 2020-02-19
  [ Apoptosis , Daphne genkwa , EGFR , Hydroxygenkwanin , NSCLC ]

• Targeting the pentose phosphate pathway increases reactive oxygen species and induces apoptosis in thyroid cancer cells
  Molecular and Cellular Endocrinology, 499, 2020-01-01
  [ Apoptosis , Pentose phosphate pathway , Reactive oxygen species , Thyroid cancer ]

• Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells
  OncoImmunology, 9, 1, 2020-01-01
  [ Cancer stem cell,CD47,ovarian cancer,tumor microenvironment ]

• Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies
  Nature Nanotechnology, 14, 12, 1160-1169, 2019-12-01

• Is papillary thyroid microcarcinoma a biologically different disease? A propensity score-matched analysis
  Journal of Surgical Oncology, 120, 6, 1023-1030, 2019-11-01

• Anticancer Effect and Mechanism of Hydroxygenkwanin in Oral Squamous Cell Carcinoma
  Frontiers in Oncology, 9, 2019-09-18
  [ apoptosis , cell cycle , invasion , migration , oral cancer , RNA sequencing ]

• A Novel Prediction Model for Bloodstream Infections in Hepatobiliary–Pancreatic Surgery Patients
  World Journal of Surgery, 43, 5, 1294-1302, 2019-05-15

• Tumor mutation burden and recurrent tumors in hereditary lung cancer
  Cancer Medicine, 8, 5, 2179-2187, 2019-05-01
  [ hereditary lung cancer , mutation load , nonsmoker , recurrence , whole genome sequencing ]

• Genome-wide scan for copy number alteration association with relapse-free survival in colorectal cancer with liver metastasis patients
  Journal of Clinical Medicine, 7, 11, 2018-11-18

• Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation
  Head and Neck, 40, 11, 2528-2537, 2018-11-01

• Heme oxygenase-1 inhibitors induce cell cycle arrest and suppress tumor growth in thyroid cancer cells
  International Journal of Molecular Sciences, 19, 9, 2018-09-01
  [ Heme oxygenase , Metabolism , Reactive oxygen species , Thyroid cancer ]

• FAM198B is associated with prolonged survival and inhibits metastasis in lung adenocarcinoma via blockage of ERK-Mediated MMP-1 expression
  Clinical Cancer Research, 24, 4, 916-926, 2018-02-15

• Comparison of topical mupirocin and gentamicin in the prevention of peritoneal dialysis-related infections: A systematic review and meta-analysis
  American Journal of Surgery, 215, 1, 179-185, 2018-01-01

• Dipeptidyl peptidase IV as a prognostic marker and therapeutic target in papillary thyroid carcinoma
  Journal of Clinical Endocrinology and Metabolism, 102, 8, 2930-2940, 2017-08-01

• Recurrence-associated genes in papillary thyroid cancer: An analysis of data from The Cancer Genome Atlas
  Surgery, 161, 6, 1642-1650, 2017-06-01

• Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer
  , 40, 12, 2922-2929, 2016-12-01

• Molecular gene signature and prognosis of non-small cell lung cancer
  , 7, 32, 51898-51907, 2016-08-01
  [ Gene signature , Non-small cell lung cancer , Prognosis , Risk score , TaqMan Low-Density Array ]

• 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane potentiates in vitro and in vivo antitumor effects of irinotecan on human colorectal cancer cells
  Oncology Letters, 11, 5, 3551-3557, 2016-05-01
  [ 1,6-bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane (DPD) , Apoptosis , COLO 205 , Colorectal cancer , Irinotecan , Microarray , NCI-60 , Pharmacokinetics ]

• EPIANNO: EPIgenomics ANNOtation tool
  PLoS ONE, 11, 2, 2016-02-01

• SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma
  , 7, 28, 44417-44429, 2016-01-01
  [ AP-1 , E-cadherin , Metastasis , SLUG , SPANX family ]

• Oncogenic miR-137 contributes to cisplatin resistance via repressing CASP3 in lung adenocarcinoma
  American Journal of Cancer Research, 6, 6, 1317-1330, 2016-01-01
  [ Caspase 3 , Chemoresistance , Cisplatin , Lung adenocarcinoma , MiR-137 ]

• Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane
  International Journal of Clinical and Experimental Medicine, 8, 9, 14805-14815, 2015-09-30
  [ Cell cycle , DPA , HCT-116 , P21 , P53 , Pharmacokinetics ]

• EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway
  Scientific Reports, 5, 2015-09-04

• R331W missense mutation of oncogene YAP1 is a germline risk allele for lung adenocarcinoma with medical actionability
  Journal of Clinical Oncology, 33, 20, 2303-2310, 2015-07-10

• CD74 expression and its therapeutic potential in thyroid carcinoma
  Endocrine-Related Cancer, 22, 2, 179-190, 2015-04-01
  [ Antibody , CD74 , Macrophage migration inhibitory factor , Thyroid cancer ]

• Slug is temporally regulated by cyclin e in cell cycle and controls genome stability
  Oncogene, 34, 9, 1116-1125, 2015-02-26

• Quality of Life after Surgery or Surveillance for Asymptomatic Primary Hyperparathyroidism: A Meta-Analysis of Randomized Controlled Trials
  Medicine (United States), 94, 23, 2015-01-01

• Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate concentrations in U.S. adults: The national health and nutrition examination survey 2005-2006
  PLoS ONE, 9, 12, 2014-12-16

• Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway
  PLoS ONE, 9, 2, 2014-02-21

• Association between parathyroid hormone levels and inflammatory markers among US adults
  Mediators of Inflammation, 2014, 2014-01-01

• Significance of Allelic Percentage of BRAF c.1799T > A (V600E) Mutation in Papillary Thyroid Carcinoma
  , 21, 4, 619-626, 2014-01-01

• The Motor Protein KIF14 Inhibits Tumor Growth and Cancer Metastasis in Lung Adenocarcinoma
  PLoS ONE, 8, 4, 2013-04-23

• Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity
  BMC Medicine, 11, 1, 2013-04-16
  [ Chemotherapy , Invasion , Metastasis , Microarray , NCI-60 ]

• Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer
  , 107, 5, 493-497, 2013-04-01
  [ inflammation , neutrophil-to-lymphocyte ratio , thyroid cancer ]

• α-catulin drives metastasis by activating ILK and driving an αvβ3 integrin signaling axis
  Cancer Research, 73, 1, 428-438, 2013-01-01

• Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma
  Cell Biochemistry and Biophysics, 65, 2, 203-210, 2013-01-01
  [ Adiponectin , Adiponectin receptor , Leptin , Obesity , Thyroid cancer ]

• Regulation of leptin receptor expression in human papillary thyroid cancer cells
  , 66, 6, 469-473, 2012-09-01
  [ Epigenetic regulation , Insulin , Leptin receptor ]

• Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells
  Oncology Reports, 27, 2, 529-534, 2012-02-01
  [ Anti-migration , Anti-proliferation , Cell cycle , Colorectal carcinoma , Diamantane , p21 ]

• Leptin enhances migration of human papillary thyroid cancer cells through the PI3K/AKT and MEK/ERK signaling pathways
  Oncology Reports, 26, 5, 1265-1271, 2011-11-01
  [ Cell migration , Leptin , MAPK , PI3K/AKT , Thyroid cancer ]

• Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations
  Journal of Clinical Oncology, 29, 25, 3435-3442, 2011-09-01

• A four-gene signature from NCI-60 cell line for survival prediction in non-small cell lung cancer
  Clinical Cancer Research, 15, 23, 7309-7315, 2009-12-01

• Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells
  Nutrition and Cancer, 61, 5, 735-745, 2009-09-01

• Mitochondria are an essential mediator of nitric oxide/cyclic guanosine 3′,5′-monophosphate blockingof glucose depletion-induced cytotoxicity in human HepG2 cells
  Molecular Cancer Research, 5, 9, 923-932, 2007-09-01

研討會著作

• A Machine Learning Approach: Early Detection of Diabetic Nephropathy Based on Laboratory Tests
  2023-06-30
  [ diabetic nephropathy,early detection,machine learning,laboratory tests ]

• Exploring Mechanisms of Gefitinib Resistance in Lung Adenocarcinoma using Systems Biology Approach
  2023-05-06
  [ gefitinib resistance,lung adenocarcinoma,exosomes,miRNAs,IGF2 ]

• Systems Biology Approaches to Explore Lung Adenocarcinoma Resistant to Gefitinib
  2023-03-31
  [ adenocarcinoma,exosomes,gefitinib,miRNAs,IGF2 ]

• The Impact of Gut Microbiota and Metabolites on Vascular Calcification in Hemodialysis Patients: An Association Analysis
  2022-12-18
  [ gut microbiota,vascular calcification,metabolites,hemodialysis,chronic kidney disease (CKD) ]

• Mechanical stretch promotes invasion of lung cancer cells via activation of tumor necrosis factor-alpha
  2022-12-18
  [ Mechanical stretch, lung cancer cells, tumor necrosis factor-alpha ]

• Omics-based human liver 3D dynamic platforms
  2022-11-19
  [ Omics-based human liver 3D dynamic platforms ]

• Association analysis between gut microbiota and their metabolites toward vascular calcification in hemodialysis patients
  2022-11-19
  [ gut microbiota,vascular calcification,metabolites,hemodialysis,chronic kidney disease (CKD) ]

• THE COVIDTW STUDY: CLINICAL PREDICTORS OF COVID-19 MORTALITY AND A NOVEL AI PROGNOSTIC MODEL BASED ON CHEST X-RAY
  2022-09-19
  [ COVID-19, CHEST X-RAY, A NOVEL AI PROGNOSTIC MODEL, CLINICAL PREDICTORS OF COVID-19 MORTALITY ]

• The effect of cyclic mechanical stretch on the 3D culture model of lung cancer cells
  2022-04-16
  [ 3d culture, lung cancer, invasion ]

• Transcriptomics research of Niemann-Pick disease
  2022-04-16
  [ NPC, RNAseq ]

• Deep learning-based lung cancer survival prognosis from multiple omics data
  2022-03-12
  [ omics, lung cancer ]

• Modified Attention Spatial Convolution Model for Skin Lesion Segmentation
  2021-01-01