國立中央大學教師履歷平台

期刊著作

• Simultaneous detection of miR-21 and miR-155 using a multiplexed silicon nanowire FET biosensor
  Microchemical Journal, 224, 2026-05-01
  [ Cancer diagnostics,Liquid biopsy,MicroRNA (miRNA),Multiplex biosensor,Silicon nanowire FET (Si-NW FET) ]

• The optimal ionic concentration of sensing buffer in the detection of RNA by using the DNA probe with the silicon nanowire field-effect transistor (SiNW-FET)
  Talanta, 295, 2025-12-01
  [ Debye length,Field-effect transistor (FET),Ionic strength,miRNA-21,Nucleic acid hybridization,Silanization reaction ]

• Ultrasensitive detection of cardiac troponin I using single-chain variable fragment antibody functionalized silicon nanowire field-effect transistor
  Microchemical Journal, 217, 2025-10-01
  [ Biosensor,Cardiac troponin I (cTnI),Debye screening effect,Field-effect transistor,Single-chained variable antibody fragment (scFv) ]

• In silico maturation of DNA aptamer against the prostate-specific antigen (PSA) and kinetic analysis
  Biochemical and Biophysical Research Communications, 759, 2025-05-20
  [ Affinity constant,Aptamer,Docking,Molecular dynamics (MD) simulations,Prostate-specific antigen (PSA),Quartz crystal microbalance (QCM) ]

• Electric-field assisted silicon nanowire field effect transistor for the ultra-low concentration nucleic acid detection
  Biosensors and Bioelectronics, 268, 2025-01-15
  [ Electric field,Field-effect transistor,Liquid gate,Nucleic acid,Short detection time ]

• An aptamer sandwich assay for protein biomarker detection by solution-gated silicon nanowire field-effect transistor systems
  Microchemical Journal, 207, 2024-12-01
  [ Aptamer sandwich assay,Aptasensor,Capacitance,Cardiac troponin I,Debye length,Solution-gated FET biosensor ]

• Intermittent lysis on a single paper-based device to extract exosomal nucleic acid biomarkers from biological samples for downstream analysis
  Mikrochimica Acta, 191, 8, 2024-08-01
  [ Chronic wound,Exosomal biomarker,Exosomal nucleic acid extraction,Human plasma,Intermittent lysis,Paper-based device,Silica nanoparticles ]

• Specific and efficient knockdown of intracellular miRNA using partially neutralized phosphate-methylated DNA oligonucleic acid-loaded mesoporous silica nanoparticles
  Journal of Materials Chemistry B, 12, 26, 6492-6499, 2024-06-04

• Comparing solution-gate and bottom-gate nanowire field-effect transistors on pH sensing with different salt concentrations and surface modifications
  Talanta, 271, 2024-05-01
  [ Bottom-gate FET,Field-effect transistor (FET),Ionic concentration,pH sensing,Solution-gate FET ]

• Integrating Sulfobetaine Methacrylate Hydrogel-Modified Cellulose Triacetate Filter into a Zwitterionized Tandem Membrane System for Exosome Isolation
  ACS Applied Polymer Materials, 6, 5, 2741-2751, 2024-03-08
  [ antifouling,cellulose triacetate membrane,exosome isolation,sulfobetaine methacrylate,zwitterionic materials ]

• Detecting glucose in a cell culture medium by surface-enhanced Raman scattering on InGaN quantum wells
  Optics Continuum, 2, 12, 2509-2515, 2023-12-15

• Paper/PMMA hybrid device with a microvalve-controlled design for exosome isolation and analysis
  Talanta, 265, 2023-12-01
  [ Exosomal miRNA,microRNA-21 (miR-21),Microvalve-controlled design,miRNA extraction,Paper/PMMA hybrid device ]

• Comparing surface modification methods for silicon nanowire field-effect transistor biosensors for diagnosis applications: A case study of cardiac troponin I
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 676, 2023-11-05
  [ (3-aminopropyl) triethoxysilane,1-(3-aminopropyl) silatrane,Cardiac troponin,Field-effect transistor biosensor,Silane-PEG,Surface modification ]

• Paper-Based Exosomal MicroRNA-21 Detection for Wound Monitoring: A Proof of Concept and Clinical Validation Trial Study
  International Journal of Molecular Sciences, 24, 12, 2023-06-01
  [ exosome,microRNA-21,P-ELISA,wound healing ]

• PLBD: protein-ligand binding database of thermodynamic and kinetic intrinsic parameters
  Database : the journal of biological databases and curation, 2023, 2023-01-01

• Ultrasensitive Detection of Interleukin 6 by Using Silicon Nanowire Field-Effect Transistors
  Sensors, 23, 2, 2023-01-01
  [ aptamer,COVID-19,field-effect transistors,infectious diseases,interleukin 6 ]

• Molecular effects of site-specific phosphate-methylated primer on the structure and motions of Taq DNA polymerase
  Computational and Structural Biotechnology Journal, 21, 1820-1827, 2023-01-01
  [ DNA polymerase,Methyl phosphotriester,Molecular dynamics,PCR,Primer ]

• Real-time changes in the AC magnetic susceptibility of reagents during immunomagnetic reduction assays
  AIP Advances, 12, 6, 2022-06-01

• In-Silico Selection of Aptamer Targeting SARS-CoV-2 Spike Protein
  International Journal of Molecular Sciences, 23, 10, 2022-05-01
  [ aptamer–protein interaction,COVID-19,DNA aptamer,infectious disease,molecular dynamics simulation,SARS-CoV-2,spike protein ]

• Paper-Based Devices for Capturing Exosomes and Exosomal Nucleic Acids From Biological Samples
  Frontiers in Bioengineering and Biotechnology, 10, 2022-04-12

• Increasing the λ-Red mediated gene deletion efficiency in Escherichia coli using methyl phosphotriester-modified DNA
  Journal of the Taiwan Institute of Chemical Engineers, 2022-01-01

• Optimizing surface modification of silicon nanowire field-effect transistors by polyethylene glycol for MicroRNA detection
  Colloids and Surfaces B: Biointerfaces, 209, 2022-01-01

• Uncertainty in protein–ligand binding constants: asymmetric confidence intervals versus standard errors
  European Biophysics Journal, 50, 3-4, 661-670, 2021-05-01
  [ Binding constant,Confidence intervals,Dissociation constant,Isothermal titration calorimetry,Log-normal distribution,Standard error ]

• Switching the Inhibitor-Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII
  ChemistryOpen, 10, 5, 567-580, 2021-05-01
  [ drug design,enzyme models,fluorescence spectroscopy,sulfonamides,X-ray diffraction ]

• Improved biomarker quantification of silicon nanowire field-effect transistor immunosensors with signal enhancement by RNA aptamer: Amyloid beta as a case study
  Sensors and Actuators, B: Chemical, 329, 2021-02-15

• Combination of aptamer amplifier and antigen-binding fragment probe as a novel strategy to improve detection limit of silicon nanowire field-effect transistor immunosensors
  Sensors, 21, 2, 1-12, 2021-01-02
  [ Aptamer,ELISA,Fab,Mixed self-assembled monolayer,Signal enhancement,Silicon nanowire field-effect transistor biosensor ]

• Improve sample preparation process for miRNA isolation from the culture cells by using silica fiber membrane
  Scientific Reports, 10, 1, 2020-12-01

• Studies of the interactions mechanism between DNA and silica surfaces by Isothermal Titration Calorimetry
  Journal of the Taiwan Institute of Chemical Engineers, 116, 62-66, 2020-11-01
  [ Adsorption mechanism,Enthalpy,Entropy,Isothermal titration calorimetry,Nucleic acid extraction,Thermodynamics ]

• Reduction of interstrand charge repulsion of DNA duplexes by salts and by neutral phosphotriesters – Contrary effects for harnessing duplex formation
  Journal of the Taiwan Institute of Chemical Engineers, 110, 1-7, 2020-05-01
  [ DNA-hydrating water , Interstrand charge repulsion , Isothermal titration calorimetry , Methyl-phosphotriester DNA oligonucleotides ]

• Predicting future prospects of aptamers in field-effect transistor biosensors
  Molecules, 25, 3, 2020-02-05
  [ Aptamer , Bio-amplifier , FET aptasensor , Field-effect transistor , Small molecule , Structure-switching ]

• Neutralized chimeric DNA probe for the improvement of GC-rich RNA detection specificity on the nanowire field-effect transistor
  Scientific Reports, 9, 1, 2019-12-01

• Field-effect transistor biosensors for biomedical applications: Recent advances and future prospects
  Sensors, 19, 19, 2019-10-01
  [ Antibody , Aptamer , Biomedical application , FET biosensor , Field-effect transistor , Nanotransducer ]

• Signal Enhancement of Silicon Nanowire Field-Effect Transistor Immunosensors by RNA Aptamer
  ACS Omega, 4, 12, 14765-14771, 2019-09-17

• Designed phosphate-methylated oligonucleotides as PCR primers for SNP discrimination
  Analytical and Bioanalytical Chemistry, 411, 17, 3871-3880, 2019-07-19
  [ Nucleotide-derivative modification,PCR,qPCR,SNP,Specificity nucleic acid methyl phosphotriester,Synthesized oligonucleotides ]

• Repeatability, precision, and accuracy of the enthalpies and Gibbs energies of a protein–ligand binding reaction measured by isothermal titration calorimetry
  European Biophysics Journal, 48, 2, 139-152, 2019-03-04
  [ Accuracy , Isothermal titration calorimetry , NITPIC software , Precision , Repeatability , SEDPHAT software ]

• Molecular self-interactions of ribonuclease A revealed by isothermal titration calorimetry and self-interaction chromatography – Effects of anisotropy of protein surface charges
  Journal of the Taiwan Institute of Chemical Engineers, 96, 74-81, 2019-03-01
  [ Charge anisotropy , Isothermal titration calorimetry , Molecular self-interaction , Ribonuclease A , Second virial coefficient ]

• Isothermal titration calorimetry for characterization of recombinant proteins
  Current Opinion in Biotechnology, 55, 9-15, 2019-02-01

• Synergetic improvements of sensitivity and specificity of nanowire field effect transistor gene chip by designing neutralized DNA as probe
  Scientific Reports, 8, 1, 2018-12-01

• Neutralized chimeric DNA probe for detection of single nucleotide polymorphism on surface plasmon resonance biosensor
  Biosensors and Bioelectronics, 99, 170-175, 2018-01-15
  [ DNA analogue , Ethylated DNA , Label-free detection , SNP genotyping , SPR imaging ]

• Nanostructured silicon substrate for desorption/ionization on silicon mass spectrometry coupled with titanium oxide and zinc oxide coated magnetic nanoparticles for phosphopeptide analysis
  Journal of Nanoscience and Nanotechnology, 17, 3, 2054-2060, 2017-03-01
  [ Desorption/ionization on silicon , Magnetic nanoparticle , Mass spectrometry , Nanostructured silicon , Phosphopeptide ]

• The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen
  BioMed Research International, 2017, 2017-01-01

• Tunable PEGylation of branch-type PEI/DNA polyplexes with a compromise of low cytotoxicity and high transgene expression: In vitro and in vivo gene delivery
  Journal of Materials Chemistry B, 5, 24, 4732-4744, 2017-01-01

• Isothermal titration calorimetry for drug design: Precision of the enthalpy and binding constant measurements and comparison of the instruments
  Analytical Biochemistry, 515, 61-64, 2016-12-15
  [ Acetazolamide , Calorimeter , Carbonic anhydrase , Enthalpy , Isothermal titration calorimetry (ITC) , Nitpic and Sedphat , Protein – ligand binding ]

• A replaceable liposomal aptamer for the ultrasensitive and rapid detection of biotin
  Scientific Reports, 6, 2016-02-23

• The consideration of indolicidin modification to balance its hemocompatibility and delivery efficiency
  , 494, 1, 498-505, 2015-10-15
  [ Cell-penetrating peptide , Direct penetration , Hydrophobicity , Indolicidin , Transmembrane mechanism ]

• Revisiting the streptavidin-biotin binding by using an aptamer and displacement isothermal calorimetry titration
  Journal of Molecular Recognition, 28, 3, 125-128, 2015-01-01
  [ Affinity constant measurement , Ligand-displacement isothermal titration calorimetry , Streptavidin-biotin binding , Thermodynamic parameters ]

• Computational selection of RNA aptamer against angiopoietin-2 and experimental evaluation
  BioMed Research International, 2015, 2015-01-01

• PEGylation site-dependent structural heterogeneity study of MonoPEGylated human parathyroid hormone fragment hPTH(1-34)
  Langmuir, 30, 38, 11421-11427, 2014-09-30

• Modification of silicone elastomer with zwitterionic silane for durable antifouling properties
  Langmuir, 30, 38, 11386-11393, 2014-09-30

• Toll-like receptor 6 and connective tissue growth factor are significantly upregulated in mitomycin-C-treated urothelial carcinoma cells under hydrostatic pressure stimulation
  Genetic Testing and Molecular Biomarkers, 18, 6, 410-416, 2014-06-01

• A polarization control system for intensity-resolved guided mode resonance sensors
  Sensors, 14, 3, 5198-5206, 2014-03-12
  [ Guided mode resonance , Photonic sensors , Polarization ellipse ]

• Strategy of Fc-recognizable peptide ligand design for oriented immobilization of antibody
  Analytical Chemistry, 86, 6, 2931-2938, 2014-01-01

• Hydrostatic pressure enhances mitomycin C induced apoptosis in urothelial carcinoma cells
  Urologic Oncology: Seminars and Original Investigations, 32, 1, 26.e17-26.e24, 2014-01-01

• The regulation of DNA adsorption and release through chitosan multilayers
  Carbohydrate Polymers, 99, 394-402, 2014-01-01
  [ Chitosan , Gene delivery , Interdiffusion , Layer-by-layer assembly , Polyelectrolyte multilayers ]

• A novel application of indolicidin for gene delivery
  , 456, 2, 293-300, 2013-09-24
  [ Cell-penetrating peptide , Gene delivery , Indolicidin , Nonviral vectors , Transfection ]

• Kosmotrope-like hydration behavior of polyethylene glycol from microcalorimetry and binding isotherm measurements
  Langmuir, 29, 13, 4259-4265, 2013-04-02

• Improved DNA detection by utilizing electrically neutral DNA probe in field-effect transistor measurements as evidenced by surface plasmon resonance imaging
  Biosensors and Bioelectronics, 41, 1, 795-801, 2013-03-15
  [ Biosensors , DNA analog , Ethylated DNA , Field-effect transistor , SPR imaging ]

• Salt bridge exchange binding mechanism between streptavidin and its DNA aptamer - Thermodynamics and spectroscopic evidences
  Journal of Molecular Recognition, 26, 3, 149-159, 2013-03-01
  [ aptamer , circular dichroism , isothermal titration calorimetry , streptavidin ]

• A model for fast predicting and optimizing the sensitivity of surface-relief guided mode resonance sensors
  Sensors and Actuators, B: Chemical, 176, 1197-1203, 2013-01-01
  [ Bulk sensitivity , Guided mode resonance device , Optical biosensors , Waveguide ]

• Structural stability-chromatographic retention relationship on exenatide diastereomer separation
  Analytical and Bioanalytical Chemistry, 404, 8, 2437-2444, 2012-11-01
  [ Diastereomer separation , Exenatide , Molecular dynamics simulation , Reversedphase chromatography , Structural stability-chromatographic retention relationship ]

• Molecular dynamics simulation of the induced-fit binding process of DNA aptamer and L-argininamide
  Biotechnology Journal, 7, 11, 1367-1375, 2012-11-01
  [ Aptamer , Induced-fit binding mechanism , L-Argininamide , Molecular dynamics simulation , Molecular recognition engineering ]

• Use of a kinesin-cro fusion protein as the nanoshuttle to transport specific DNA
  Current Nanoscience, 8, 5, 669-675, 2012-10-29
  [ Kinesin , Molecular shuttles , Nano biotechnology , Protein engineering ]

• Retention prediction of peptide diastereomers in reversed-phase liquid chromatography assisted by molecular dynamics simulation
  Langmuir, 28, 38, 13601-13608, 2012-09-25

• Use of biotinylated chitosan for substrate-mediated gene delivery
  Bioconjugate Chemistry, 23, 8, 1587-1599, 2012-08-15

• Monitoring DNA hybridization with a simply manufactured GMR biosensor
  Life Science Journal, 9, 2, 1015-1019, 2012-06-25
  [ Biosensor,Cost down,DNA hybridization,Guided-mode resonance,Real time monitoring,Reliability,Simply manufacture,Stability ]

• Sensitive metal layer assisted guided mode resonance biosensor with a spectrum inversed response and strong asymmetric resonance field distribution
  , 20, 13, 14584-14593, 2012-06-18

• Nanostructured silicon surface modifications for as a selective matrix-free laser desorption/ionization mass spectrometry
  The Analyst, 137, 11, 2643-2650, 2012-06-07

• Optimization of DNA-directed immobilization on mixed oligo(ethylene glycol) monolayers for immunodetection
  Analytical Biochemistry, 423, 1, 26-35, 2012-04-01
  [ DNA-directed immobilization (DDI) , Oligo(ethylene glycol) (OEG) , Optimization , Self-assembled monolayer (SAM) , Surface plasmon resonance (SPR) ]

• Bioadhesive control of plasma proteins and blood cells from umbilical cord blood onto the interface grafted with zwitterionic polymer brushes
  Langmuir, 28, 9, 4309-4317, 2012-03-06

• Rapid analysis of abused drugs using nanostructured silicon surface assisted laser desorption/ionization mass spectrometry
  The Analyst, 137, 3, 654-661, 2012-02-07

• Biofouling resistance of ultrafiltration membranes controlled by surface self-assembled coating with PEGylated copolymers
  Langmuir, 28, 2, 1399-1407, 2012-01-17

• Studies of the binding mechanism between aptamers and thrombin by circular dichroism, surface plasmon resonance and isothermal titration calorimetry
  Colloids and Surfaces B: Biointerfaces, 88, 2, 552-558, 2011-12-01
  [ Aptamer , Binding mechanism , Thrombin ]

• Capacitance sensor system for oligonucleotide hybridization detection
  Sensors and Materials, 23, 2, 111-119, 2011-12-01
  [ Biosensor,Capacitance,Detection,Interdigitated chip,Oligonucleotide ]

• Surface plasmon resonance biosensor for microalbumin detection
  Journal of the Taiwan Institute of Chemical Engineers, 42, 5, 696-700, 2011-09-01
  [ Cibacron Blue F3G-A , Human serum albumin , Surface plasmon resonance ]

• A guided mode resonance aptasensor for thrombin detection
  Sensors, 11, 9, 8953-8965, 2011-09-01
  [ Affinity constant , Aptamer , Guided mode resonance , Optical biosensor , Thrombin ]

• Evaluation of bioactivity and effect of polymeric stabilizers during heat treatment for the unfolded fraction of human epidermal growth factor
  Journal of Fiber Science and Technology, 67, 8, 185-191, 2011-08-01
  [ PROTEIN STABILITY,FACTOR RECEPTOR,CELLS,PROLIFERATION,CONFORMATION,FIBROBLASTS,MEMBRANES,PEPTIDES,SEQUENCE,SURFACE ]

• Using isothermal titration calorimetry to real-time monitor the heat of metabolism: A case study using PC12 cells and Aβ(1-40)
  Colloids and Surfaces B: Biointerfaces, 83, 2, 307-312, 2011-04-01
  [ β-Amyloid , Alzheimer's disease , Biothermodynamics , Isothermal titration calorimetry ]

• Fabrication of nanostructured silicon by metal-assisted etching and its effects on matrix-free laser desorption/ionization mass spectrometry
  Analytica Chimica Acta, 687, 2, 97-104, 2011-02-21
  [ Desorption/ionization on silicon , Mass spectrometry , Matrix-free laser desorption/ionization , Metal-assisted etching , Nanostructured silicon ]

• Investigating the effects of sodium dodecyl sulfate on the aggregative behavior of hen egg-white lysozyme at acidic pH
  Colloids and Surfaces B: Biointerfaces, 81, 1, 141-151, 2010-11-01
  [ Aggregation , Amyloid fibril , Fibrillation , Hen lysozyme , Sodium dodecyl sulfate ]

• Daunomycin interaction with DNA: Microcalorimetric studies of the thermodynamics and binding mechanism
  Biotechnology Journal, 5, 10, 1069-1077, 2010-10-01
  [ Analytical biotechnology , Binding mechanism , Daunomycin , Nucleic acids , Thermodynamics ]

• Development of capacitance measurement system for human serum albumin detection
  Electronics Letters, 46, 10, 678-680, 2010-05-13

• Tunable bioadhesive copolymer hydrogels of thermoresponsive poly(N -isopropyl acrylamide) containing zwitterionic polysulfobetaine
  Biomacromolecules, 11, 4, 1101-1110, 2010-04-12

• A systematic SPR study of human plasma protein adsorption behavior on the controlled surface packing of self-assembled poly(ethylene oxide) triblock copolymer surfaces
  Journal of Biomedical Materials Research - Part A, 93, 1, 400-408, 2010-04-01
  [ Biocompatibility , Nonfouling surface , PEO-PPO-PEO , Surface plasmon resonance , Triblock copolymers ]

• Hemocompatible mixed-charge copolymer brushes of pseudozwitterionic surfaces resistant to nonspecific plasma protein fouling
  Langmuir, 26, 5, 3522-3530, 2010-03-02

• Peroxidase activity of DNA aptamer-Pt complexes prepared with cisplatin
  Journal of Biomaterials Science, Polymer Edition, 21, 1, 67-82, 2010-01-01
  [ Aptamer , Bioassay , DNA , DNA enzyme , Peroxidase ]

• Recent trends and some applications of isothermal titration calorimetry in biotechnology
  Biotechnology Journal, 5, 1, 85-98, 2010-01-01
  [ Binding affinity , Biorecognition , Bioseparation , Isothermal titration calorimetry , Thermodynamics ]

• Thermodynamic basis of chiral recognition in a DNA aptamer
  Physical Chemistry Chemical Physics, 11, 42, 9744-9750, 2009-11-04

• Dynamic fluorescence imaging analysis to investigate the cholesterol recruitment in lipid monolayer during the interaction between β-amyloid (1-40) and lipid monolayers
  Colloids and Surfaces B: Biointerfaces, 74, 1, 59-66, 2009-11-01
  [ β-Amyloid , Alzheimer's disease , Fluorescence imaging analysis , Lipid monolayer , Recruiting hypothesis ]

• Separation of hematopoietic stem and progenitor cells from human peripheral blood through polyurethane foaming membranes modified with several amino acids
  Journal of Applied Polymer Science, 114, 2, 671-679, 2009-10-15
  [ Bioengineering , Biomaterials , Hematopoietic stem cells , Polyurethanes , Separation techniques ]

• Permeation of blood cells from umbilical cord blood through surface-modified polyurethane foaming membranes
  Journal of Membrane Science, 339, 1-2, 184-188, 2009-09-01
  [ Bioseparation , Blood cells , Filtration , Hematopoietic stem cells , Polyurethanes ]

• Sulfobetaine-grafted poly(vinylidene fluoride) ultrafiltration membranes exhibit excellent antifouling property
  Journal of Membrane Science, 339, 1-2, 151-159, 2009-09-01
  [ Graft copolymerization , Low biofouling property , Poly(sulfobetaine methacrylate) , Poly(vinylidene fluoride) , Protein adsorption , Surface-initiated atom transfer radical polymerization ]

• Dual-thermoresponsive phase behavior of blood compatible zwitterionic copolymers containing nonionic poly(N-isopropyl acrylamide)
  Biomacromolecules, 10, 8, 2092-2100, 2009-08-10

• A new PZT piezoelectric sensor for gravimetric applications using the resonance-frequency detection
  Sensors and Actuators, B: Chemical, 139, 2, 259-264, 2009-06-04
  [ Biosensor , Lead zironate titanate (PZT) , Piezoelectric , Resonance frequency ]

• Preparation of fractioned DNA aptamer-Pt complex through ultrafiltration and the colorimetric sensing of thrombin
  Journal of Membrane Science, 328, 1-2, 97-103, 2009-02-05
  [ Aptamer , Colorimetric sensing , DNA , DNAzyme , Platinum complex , Ultrafiltration ]

• Preparation of a DNA aptamer-Pt complex and its use in the colorimetric sensing of thrombin and anti-thrombin antibodies
  Analytical Chemistry, 80, 17, 6580-6586, 2008-09-01

• Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide
  Colloids and Surfaces B: Biointerfaces, 65, 2, 172-177, 2008-09-01
  [ β-Amyloid (Aβ) , Cholesterol , Cytotoxicity , Ganglioside ]

• Separation of hematopoietic stem cells from human peripheral blood through modified polyurethane foaming membranes
  Journal of Biomedical Materials Research - Part A, 85, 4, 853-861, 2008-06-15
  [ Blood , CD34 cell , Cell separation , Hematopoietic stem cell , Polyurethane membrane ]

• Investigation of the mechanism of β-amyloid fibril formation by kinetic and thermodynamic analyses
  Langmuir, 24, 11, 5802-5808, 2008-06-03

• Microcalorimetrics studies of the thermodynamics and binding mechanism between L-tyrosinamide and aptamer
  Journal of Physical Chemistry B, 112, 21, 6665-6673, 2008-05-29

• A highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion
  Langmuir, 24, 10, 5453-5458, 2008-05-20

• The investigation of recognition interaction between phenylboronate monolayer and glycated hemoglobin using surface plasmon resonance
  Analytical Biochemistry, 375, 1, 90-96, 2008-04-01
  [ Glycated hemoglobin (HbA1c) , Phenylboronic acid , Surface plasmon resonance (SPR) ]

• Preparation of poly(vinylidene fluoride) microfiltration membrane with uniform surface-copolymerized poly(ethylene glycol) methacrylate and improvement of blood compatibility
  Journal of Membrane Science, 309, 1-2, 165-174, 2008-02-15
  [ Blood compatibility , Graft copolymerization , Microfiltration membrane , Poly(ethylene glycol) methacrylate , Poly(vinylidene fluoride) ]

• Preservation of hematopoietic stem and progenitor cells from umbilical cord blood stored in a surface derivatized with polymer nanosegments
  Biomacromolecules, 9, 2, 634-639, 2008-02-01

• Novel enzymatic properties of DNA-Pt complexes
  Biomacromolecules, 8, 9, 2684-2688, 2007-09-01

• A multispot DNA chip fabricated with mixed ssDNA/oligo (ethylene glycol) self-assembled monolayers for detecting the effect of secondary structures on hybridization by SPR imaging
  Sensors and Actuators, B: Chemical, 125, 2, 607-614, 2007-08-08
  [ Hybridization , Multispot DNA chip , Secondary structure , Surface plasmon resonance imaging ]

• Exploring the effect of cholesterol in lipid bilayer membrane on the melittin penetration mechanism
  Analytical Biochemistry, 367, 1, 49-55, 2007-08-01

• Kinetics and enthalpy measurements of interaction between β-amyloid and liposomes by surface plasmon resonance and isothermal titration microcalorimetry
  Colloids and Surfaces B: Biointerfaces, 58, 2, 231-236, 2007-08-01
  [ β-Amyloid (Aβ) , Enthalpy , Isothermal titration calorimetry , Lipsome , Surface plasmon resonance ]

• Visible light regulates neurite outgrowth of nerve cells
  Cytotechnology, 54, 3, 181-188, 2007-07-01
  [ Cell , LED , Nerve , Neurite outgrowth , Visible light ]

• Molecular dynamics simulations to investigate the domain swapping mechanism of human cystatin C
  Biotechnology Progress, 23, 3, 577-584, 2007-05-01

• The hydrophobic interactions of the ion-exchanger resin ligands with proteins at high salt concentrations by adsorption isotherms and isothermal titration calorimetry
  Separation and Purification Technology, 54, 2, 212-219, 2007-04-01
  [ Adsorption enthalpy , Hydrophobic interaction , Ion-exchange resin , Isothermal titration calorimetry ]

• Kinetics and morphology analysis for fabrication a mimetic bio-membrane on Brij-76 derived surface
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 296, 1-3, 86-91, 2007-03-15
  [ Cholesterol , DPPC , Egg PC , Kinetics , Liposome , Morphology , Sensor ]

• Studies of the interaction mechanism between single strand and double-strand DNA with hydroxyapatite by microcalorimetry and isotherm measurements
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 295, 1-3, 274-283, 2007-03-01
  [ Binding isotherm , dsDNA , Hydroxyapatite (HA) , Isothermal titration calorimetry , ssDNA ]

• Molecular dynamics simulations of human cystatin c and its l68q varient to investigate the domain swapping mechanism
  Journal of Biomolecular Structure and Dynamics, 25, 2, 135-144, 2007-01-01
  [ Alzheimer's disease , Domain swapping , Hereditary cystatin C amyloid angiopathy , Human cystatin C , Hydrophobic core , Molecular dynamics simulation , Zip-up ]

• Interactions between amphiphilic graft copolymer-intercalated liposomes
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 277, 1-3, 44-51, 2006-04-05
  [ Amphiphilic graft copolymer , Colloidal stability , Inter-vesicle interactions , Liposomes ]

• Characterization of the interaction of galectin-1 with sodium arsenite
  , 19, 3, 469-474, 2006-03-01

• Effects of solute-matrix interaction on monitoring the conformational changes of immobilized proteins by surface plasmon resonance sensor
  Talanta, 67, 4, 862-867, 2005-10-15
  [ Denaturant , Protein conformation , Refractive index , Surface plasmon resonance ]

• Effect of amino acid sequence on the hydrophobicity of small peptides
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 266, 1-3, 175-180, 2005-09-15
  [ Decyl-CM-sepharose , Enthalpy , Entropy , Gibbs free energy , Hydrophobic amino acids , Hydrophobic interaction , Octyl ]

• Thermodynamics and mechanism of ssDNA hybridization below the melting temperature by isothermal titration calorimetry
  Thermochimica Acta, 433, 1-2, 83-87, 2005-08-01
  [ DNA hybridization , Enthalpy , Gene chip , Isothermal titration calorimetry ]

• The effects of denaturants on protein conformation and behavior at air/solution interface
  Colloids and Surfaces B: Biointerfaces, 41, 1, 1-6, 2005-03-10
  [ Air/solution interface , Conformation , Denaturants , Protein monolayer ]

• An investigation into the influence of secondary structures on DNA hybridization using surface plasmon resonance biosensing
  Chemical Physics Letters, 397, 4-6, 429-434, 2004-10-21

• A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film
  Biosensors and Bioelectronics, 19, 11, 1465-1471, 2004-06-15
  [ Au nanoclusters,Optical biosensor,Surface plasmon resonance,Surface-enhanced Raman scattering ]

• Method for producing coded micro-carrier and test method by using a novel type biochip
  Journal of Biotechnology, 108, 1, 1-9, 2004-02-19
  [ Coded micro-carrier , Image fusion , LIGA-like process , Surface modification method , Wavelet ]

• Effect of Temperature on Hydrophobie Interaction between Proteins and Hydrophobic Adsorbents: Studies by Isothermal Titration Calorimetry and the van't Hoff Equation
  Langmuir, 19, 22, 9395-9403, 2003-10-28

• Microcalorimetric studies of the mechanism of interaction between designed peptides and hydrophobic adsorbents
  Journal of Colloid and Interface Science, 263, 1, 23-28, 2003-07-01
  [ Cation-π interaction , Dilution enthalpy , Hydrophobic interaction , Microcalorimetry , Tryptophan ]

• Microcalorimetric investigation of the interaction of polysorbate surfactants with unilamellar phosphatidylcholines liposomes
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 213, 1, 7-14, 2003-02-04
  [ Isothermal titration calorimetry , Phosphatidylcholine liposome , Physical stability , Polysorbate surfactants , Zeta potential ]

• Microcalorimetric studies on the physical stability of poly-ethylene glycol-grafted liposome
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 212, 2-3, 227-234, 2003-01-23
  [ Interaction potential , Physical stability , Poly-ethylene glycol-liposome , Zeta potential ]

• Effect of block size and sequence on the micellization, hydrophobicity, and surface adsorption of ABC triblock methacrylic polyampholytes by isothermal titration calorimetry
  Journal of the Chinese Institute of Chemical Engineers, 33, 6, 599-608, 2002-11-01
  [ Adsorption , Critical micelle concentration , Hydrophobicity , Isothermal titration calorimetry , Methacrylic polyampholytes , Triblock copolymer ]

• Renaturation and interaction of ribonuclease A with AOT surfactant in reverse micelles
  Biotechnology Progress, 18, 6, 1443-1446, 2002-11-01

• Modification of methyl methacrylate triblock copolymer with chelating agent and its application in protein affinity coprecipitation
  Journal of the Chinese Institute of Chemical Engineers, 33, 4, 397-405, 2002-07-01
  [ Affinity coprecipitation , Iminodiacetic acid , Methyl methacrylate triblock copolymer , Protein purification ]

• Thermodynamic analysis of the interaction between proteins and solid surfaces: Application to liquid chromatography
  Journal of Molecular Recognition, 15, 2, 55-93, 2002-05-04

• Isothermal titration microcalorimetric studies of the effect of salt concentrations in the interaction between proteins and hydrophobic adsorbents
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 197, 1-3, 111-118, 2002-02-04
  [ Enthalpy change , HIC , Hydrophobic interaction chromatography , Isothermal titration calorimeter , ITC , Protein adsorption , Protein purification , Salt concentration , Thermodynamics ]

• Microcalorimetric studies on the interaction mechanism between proteins and hydrophobic solid surfaces in hydrophobic interaction chromatography: Effects of salts, hydrophobicity of the sorbent, and structure of the protein
  Analytical Chemistry, 73, 16, 3875-3883, 2001-08-15

• Molecular recognition in imprinted polymers: Thermodynamic investigation of analyte binding using microcalorimetry
  Journal of Chromatography A, 923, 1-2, 1-6, 2001-07-20
  [ 2,4-Dichlorophenoxyacetic acid , Binding mechanism , Isothermal titration calorimetry , Microcalorimetry , Molecular imprinting ]

• Microcalorimetric study of the effect of hexa-histidine tag and denaturant on the interaction mechanism between protein and metal-chelating gel
  Journal of Colloid and Interface Science, 238, 2, 333-339, 2001-06-15
  [ Adsorption enthalpy , Immobilized metal ion affinity chromatography, IMAC , Isothermal titration calorimetry, ITC , Poly-histidine tag , Protein adsorption , Schistosoma japonicum glutathione-S-transferase ]

• Microcalorimetric studies of the interaction mechanisms between proteins and Q-Sepharose at pH near the isoelectric point (pI): Effects of NaCl concentration, pH value, and temperature
  Journal of Chromatography A, 912, 2, 281-289, 2001-04-06
  [ Adsorption , Calorimetry , Isothermal titration calorimetry , Lactoglobulins , Proteins , Thermodynamic parameters ]

• Microcalorimetric and shear studies on the effects of cholesterol on the physical stability of lipid vesicles
  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 172, 1-3, 57-67, 2000-10-25
  [ Cholesterol , ITC , Phosphatidylcholine bilayer vesicles , Physical stability , Surface potential ]

• Isothermal titration microcalorimetric studies of the effect of temperature on hydrophobic interaction between proteins and hydrophobic adsorbents
  Journal of Colloid and Interface Science, 229, 2, 600-606, 2000-09-15
  [ Adsorption , Hydrophobic interaction chromatography , Isothermal titration calorimeter , Protein , Temperature ]

• The effects of cholesterol on the release of free lipids and the physical stability of lecithin liposomes
  Journal of the Chinese Institute of Chemical Engineers, 31, 3, 269-276, 2000-05-01
  [ Cholesterol , Free-lipid , Interaction force , Liposome , Shear force , Zeta-potential ]

• Microcalorimetric studies of interactions between proteins and hydrophobic ligands in hydrophobic interaction chromatography: Effects of ligand chain length, density and the amount of bound protein
  Journal of Chromatography A, 872, 1-2, 37-47, 2000-03-03
  [ Adsorption enthalpy , Isothermal titration calorimetry , Protein adsorption , Proteins , Thermodynamic parameters ]

• Determination of the second virial coefficient of the interaction between microemulsion droplets by microcalorimetry
  Langmuir, 16, 2, 300-302, 2000-01-25

• Microcalorimetric and conductivity studies of the effects of solutes on the percolation behavior of reverse micelle systems
  Journal of the Chinese Institute of Chemical Engineers, 31, 5, 455-464, 2000-01-01
  [ Amino acid , Conductivity , Microcalorimetry , Percolation , Protein , Reverse micelle ]

• Selective separation of caseinophosphopeptides through immobilized metal ion affinity chromatography: Effects of pH values, salt concentrations and degree of phosphorylation
  Bioprocess Engineering, 23, 5, 467-471, 2000-01-01

• Application of steric-mass action model to triblock copolymer as a displacer in Ion-exchange displacement chromatography
  Journal of the Chinese Institute of Chemical Engineers, 30, 5, 375-382, 1999-09-01
  [ Ion Exchange Chromatography , Molecular Design , Steric Mass Action Model , Triblock Copolymer ]

• Microcalorimetric studies of the interactions of lysozyme with immobilized metal ions: Effects of ion, pH value, and salt concentration
  Journal of Colloid and Interface Science, 214, 2, 373-379, 1999-06-15
  [ Adsorption , IMA , Immobilized metal ion affinity , Lysozyme , Microcalorimetry ]

• Protein separation by hydrophobic interaction chromatography using methacrylic block copolymers as displacers
  Journal of Chromatography A, 824, 1, 35-43, 1998-10-16
  [ Chymotrypsin , Displacement , Methacrylic block polymers , Proteins , Trypsin ]

• Entropy-driven binding/partition of amino acids/dipeptides to stratum corneum lipid vesicles
  , 50, 1-3, 51-59, 1998-01-02
  [ Amino acids/dipeptides , Entropy-driven binding , Isothermal titration calorimetry , Partition coefficient , Stratum corneum lipid vesicles ]

• Microcalorimetric studies of the interactions of lysozyme with immobilized Cu(II): Effects of pH value and salt concentration
  Journal of Colloid and Interface Science, 190, 1, 49-54, 1997-06-01
  [ Adsorption , IMA , Immobilized metal ion affinity , Lysoszyme , Microcalorimetry ]

• The role of electroosmotic flow on in-vitro transdermal iontophoresis
  , 43, 1, 23-33, 1997-01-03
  [ Electroosmotic flow , Hydrophobicity , In vitro , Iontophoresis ]

• In vitro study of enzymatic degradation of biological tissues fixed by glutaraldehyde or epoxy compound
  Journal of Biomaterials Science, Polymer Edition, 8, 8, 587-600, 1997-01-01
  [ Biological tissue , Collagenase , Degradation , Epoxy compound , Glutaraldehyde , Microcalorimetry ]

• Protein effects on the bounded water of reverse micelles
  Journal of the Chinese Institute of Chemical Engineers, 27, 5, 1996-12-01
  [ Bounded Water , Cytochromec Protein , DSC , Latent Heat , Reverse Micelles ]

• Microcalorimetric studies of the interactions of imidazole with immobilized Cu(II): Effects of pH value and salt concentration
  Journal of Colloid and Interface Science, 183, 1, 236-242, 1996-10-15
  [ adsorption , IMA , imidazole , immobilized metal ion affinity , microcalorimetry ]

• Interactions of imidazole and proteins with immobilized Cu(II) ions: Effects of structure, salt concentration, and pH in affinity and binding capacity
  Journal of Colloid and Interface Science, 180, 1, 135-143, 1996-06-01
  [ binding affinity , immobilized metal ion affinity , interaction , protein ]

• A method to predict the transdermal permeability of amino acids and dipeptides through porcine skin
  , 38, 2-3, 229-234, 1996-01-01
  [ Amino acid , In vitro penetration , Peptide , Skin model , Transdermal drug delivery ]

• Effect of Block Size and Sequence on the Micellization of ABC Triblock Methacrylic Polyampholytes
  Macromolecules, 28, 25, 8604-8611, 1995-12-01

• The sorption of lysozyme and ribonuclease onto ferromagnetic nickel powder 1. Adsorption of single components
  Colloids and Surfaces B: Biointerfaces, 5, 1-2, 25-34, 1995-09-25
  [ Adsorption , Ferromagnetic nickel powder , Lysozyme , Ribonuclease ]

• Determination of the binding constant of imidazole and histidine with immobilized Cu(II) by differential UV spectroscopy
  Journal of the Chinese Institute of Chemical Engineers, 26, 2, 81-87, 1995-03-01

• Designing peptide by molecular recognition theory as affinity adsorption ligand for peptide purification in affinity chromatography
  Journal of the Chinese Institute of Chemical Engineers, 26, 1, 19-25, 1995-01-01

• Calculation of relative binding of free energy of vancomycin with diacetyl-l-lysyl-d-alanyl-d-alanine and diacetyl-l-lysyl-l-alanyl-l-alanine
  Journal of Fermentation and Bioengineering, 80, 2, 136-140, 1995-01-01
  [ molecular modeling , peptide ligand , perturbation method , relative binding free energy , vancomycin ]

• Determination of the binding constant of imidazole and histidine with immobilized cu (ii) by differential uv spectroscopy
  Journal of Chemical Engineering of Japan, 28, 4, 419-424, 1995-01-01
  [ Binding Constant , Immobilized Metal Ion Affinity , UV Differential Spectroscopy ]

• The Effects of Amino Acid Sequence on the Partition of Peptides in Aqueous Two-Phase System
  Journal of Chemical Engineering of Japan, 27, 5, 688-690, 1994-01-01
  [ Amino Acid Sequence,Aqueous Two-Phase System,Hytlrciphobidty,Pepixle ]

• The role of polymer support crosslinking on reaction rates for solid-phase peptide synthesis
  Chemical Engineering Science, 44, 11, 2760-2762, 1989-01-01

• Reaction Rates for the Production of Polyphenylalanine and Polyserine by Solid Phase Peptide Synthesis with Low Excesses of the Symmetrical Anhydride
  Biotechnology Progress, 5, 2, 51-56, 1989-01-01

研討會著作

• PROGRAMMABLE ACTIVE FLOW CONTROL SYSTEM FOR MICROFLUIDIC PAPER-BASED ANALYTICAL DEVICES (μPADS) BY SIMPLE SCREW DRIVE
  1308-1310, 2023-01-01
  [ flow control,microvalve,μPADs ]

• Silanization of Silicone Elastomer with Zwitterionic Surface Modifier for Robust Biocompatibility
  1-4, 2015-01-01
  [ Anti-fouling , Biocompatibility , Contact lenses , Zwitterionic materials ]

• Nanostructured silicon coupled with iron oxide magnetic nanoparticles as enhanced desorption/ionization on silicon mass spectrometry for phosphopeptide analysis
  34-38, 2015-01-01
  [ Desorption/ionization on silicon , Magnetic nanoparticle , Mass spectrometry , Nanostructured silicon , Phosphopeptide ]

• Metal-assisted guided-mode resonance device for biosensing
  2012-06-13
  [ Biosensing , Diffraction grating , Guided waves , Metal , Waveguide ]

• Real-time monitoring on peptide synthesis by GMR biosensors
  1858-1861, 2011-12-01
  [ guided-mode resonance , kinetics analysis , peptide synthesis , real-time monitoring system , waveguide ]

• Real-time monitoring DNA hybridization by guided resonant mode biosensor
  1208-1211, 2011-10-04
  [ Grating , Guided-mode resonance , Soft lithography , Sol-Ge , Subwavelength ]

• Fabrication of silicon nanostructure by metal-assisted etching and its effects to matrix-free laser desorption/ionization mass spectrometry
  1286-1288, 2010-12-01
  [ Desorption/ionization on silicon , Matrix-free laser de-sorption/ionization mass spectrometry , Metal-assisted etching , Nanofilament silicon , Nanostructured silicon surface ]

• Preservation of hematopoietic stem cells on pluronic-immobilized surface
  2008-12-01
  

• Preparation and characterization of DNA-Pt complexes as novel enzymatic properties
  2008-12-01
  

• Separation and purification of hematopoietic stem cells from human blood through surface-modified membranes
  2008-12-01
  

• An investigation into the influence of secondary structures for DNA hybridization using surface plasmon resonance and surface-enhanced Raman scattering
  2006-06-26
  [ DNA secondary structural effect , Nanoparticles , Structural change , Surface plasmon resonance , Surface-enhanced Raman scattering ]

• Performance of a cell recycling continuous fermentation system for the production of n-butanol by Clostridium acetobutylicum
  471-478, 1985-12-01
  

專書

• Methods in Molecular Biology
  261-273, 2022-01-01
  [ nDNA,PCR,RT-PCR ]

• Lecture Notes in Electrical Engineering
  31-38, 2020-01-01
  [ Aptamer,IgG1,Molecular simulation,Phosphate-methylated nucleotide ]

• Lecture Notes in Electrical Engineering
  11-19, 2019-01-01
  [ Aptamer,Fc fragment,IgG,Molecular simulation,Mutated sequence ]

• Lecture Notes in Electrical Engineering
  46-55, 2018-01-01
  [ Aptamer,Molecular simulation,Prostate specific antigen (PSA),Quartz crystal microbalance (QCM) ]

• Applied Mechanics and Materials
  398-402, 2013-02-20
  [ DNA-Directed Immobilization,Oligo(ethylene Glycol),Protein Chip,Regeneration,Surface Plasmon Resonance ]

• Lecture Notes in Electrical Engineering
  743-749, 2013-01-01
  [ Aptamers,Molecular simulation,Pairwise shape complementarity,Selection,Thrombin ]

• Progress in Biotechnology
  137-141, 2000-01-01
  

• Progress in Biotechnology
  59-62, 2000-01-01