國科會計畫統計

• 開發具免疫調節、磁振影像追蹤與磁導引光熱治療功能之氧化鐵@糖基塗 層聚合光敏材料奈米粒子於膠質母細胞瘤模式之應用
  1140801~1170731
  [膠質母細胞瘤,診斷治療奈米製劑,光熱療法,免疫治療,磁振造影 , Glioblastoma,Theranostic probe,photothermal therapy,immunotherapy,MRI]

• 建構具微環境之多重基因突變腦瘤類器官平台以探勘免疫暨合併治療效益(2/2)
  1140301~1150228
  [膠質母細胞瘤,類器官,基因編輯,免疫治療,藥物篩選平台 , Glioblastoma,organoid,gene editing,immunotherapy,drug selection platform]

• 評估長效型血清白蛋白修飾新型介白素15增強免疫檢查點抑制劑與放射治療 於膠質母細胞瘤療效和機制
  1140201~1150731
  [膠質母細胞瘤,介白素15,放射治療,免疫檢查點抑制劑,纖維母細胞生長因子/受體,磁振造影 , Glioblastoma,IL-15,radiotherapy,immune checkpoint inhibitors,FGF/FGFR,MRI]

• 建構具微環境之多重基因突變腦瘤類器官平台以探勘免疫暨合併治療效益(1/2)
  1140201~1140228
  [膠質母細胞瘤,類器官,基因編輯,免疫治療,藥物篩選平台 , Glioblastoma,organoid,gene editing,immunotherapy,drug selection platform]

期刊著作

• Mechanistic insights of lenvatinib: enhancing cisplatin sensitivity, inducing apoptosis, and suppressing metastasis in bladder cancer cells through EGFR/ERK/P38/NF-κB signaling inactivation
  Cancer Cell International, 25, 1, 2025-12-01
  [ Bladder cancer,Cisplatin,EGFR,ERK,Lenvatinib,NF-κB ]

• Innovative dual-gene delivery platform using miR-124 and PD-1 via umbilical cord mesenchymal stem cells and exosome for glioblastoma therapy
  Journal of Experimental and Clinical Cancer Research, 44, 1, 2025-12-01
  [ CDK4/6,Gene therapy,Glioblastoma,miR-124,Umbilical cord mesenchymal stem cells ]

• Amentoflavone inhibits colorectal tumor growth, stemness, and metastasis, prolonging survival through GLI-1/IL6/STAT3 axis targeting
  Biomedicine and Pharmacotherapy, 191, 2025-10-01
  [ Amentoflavone,G1-arrest,GLI-1,IL-6/STAT3,metastasis,stemness ]

• Imipramine Inhibits Osteosarcoma Invasion via Src Inactivation and Caspase-Dependent Apoptosis
  Journal of Cellular and Molecular Medicine, 29, 17, 2025-09-01
  [ apoptosis,imipramine,invasion,osteosarcoma,Src ]

• Magnolol as a Radiotherapy Enhancer in Oral Squamous Cell Carcinoma: Targeting the EGFR/NF-κB Pathway and Immune Modulation
  Journal of Cellular and Molecular Medicine, 29, 16, 2025-08-01
  [ EGFR/NF-κB,immunoregulation,magnolol,oral squamous cell carcinoma,radiotherapy ]

• Amentoflavone Enhances the Anti-tumor Activity of Regorafenib by Promoting Apoptosis and Inhibiting NF-κB-mediated Metastasis in Hepatocellular Carcinoma
  Anticancer Research, 45, 7, 3045-3058, 2025-07-01
  [ Amentoflavone,apoptosis,hepatocellular carcinoma,NF-κB,Regorafenib ]

• Magnolol Suppresses Osteosarcoma Progression via Apoptosis Induction and EGFR/AKT Pathway Inactivation in a U-2 OS Xenograft Model
  Anticancer Research, 45, 7, 2949-2961, 2025-07-01
  [ AKT,apoptosis,EGFR,Magnolol,osteosarcoma ]

• Fluoxetine Suppresses Osteosarcoma Progression In Vivo by Inducing Apoptosis and Inhibiting the AKT/mTOR/NF‐κB Signaling Pathway
  Anticancer Research, 45, 4, 1465-1480, 2025-04-01
  [ AKT/PRAS40/mTOR/NF-κB,apoptosis,fluoxetine,Osteosarcoma (OSCC) ]

• Imipramine-induced Apoptosis and Metastasis Inhibition in Human Bladder Cancer T24 Cells Through EGFR/ERK/NF-κB Pathway Suppression
  In Vivo, 39, 2, 669-682, 2025-03-01
  [ bladder cancer,EGFR,ERK,Imipramine,NF-B ]

• Imipramine-mediated Suppression of EGFR Signaling Attenuates Invasive and Progressive Abilities of Hepatocellular Carcinoma Cells
  Anticancer Research, 44, 12, 5323-5335, 2024-12-01
  [ epidermal growth factor receptor (EGFR),Hepatocellular carcinoma,imipramine,metastasis ]

• A multifunctional PEGylated liposomal-encapsulated sunitinib enhancing autophagy, immunomodulation, and safety in renal cell carcinoma
  Journal of Nanobiotechnology, 22, 1, 2024-12-01
  [ Drug delivery,Immune modulation,Liposome,Renal cell carcinoma,Sunitinib ]

• Harnessing the Power of Sugar-Based Nanoparticles: A Drug-Free Approach to Enhance Immune Checkpoint Inhibition against Glioblastoma and Pancreatic Cancer
  ACS Nano, 18, 42, 28764-28781, 2024-10-22
  [ and pancreatic cancer,glioblastoma,glycopolymer,immune checkpoint therapy,macrophage polarization,monocarboxylate transporter 4,sugar-based nanoparticle ]

• Magnolol Induces Apoptosis and Suppresses Immune Evasion in Non-small Cell Lung Cancer Xenograft Models
  Anticancer Research, 44, 10, 4327-4337, 2024-10-01
  [ apoptosis,Magnolol,non-small cell lung cancer,radiotherapy,tumor microenvironment ]

• Magnolol’s Therapeutic Efficacy and Immunomodulatory Effects in Oral Squamous Cell Carcinoma
  In Vivo, 38, 5, 2152-2164, 2024-09-01
  [ apoptosis,CD8 T cells,immunosuppressive,Magnolol,oral squamous cell carcinoma ]

• Manipulating the Crosstalk between Cancer and Immunosuppressive Cells with Phototherapeutic Gold-Nanohut for Reprogramming Tumor Microenvironment
  Advanced Science, 11, 32, 2024-08-27
  [ checkpoint immunotherapy,magnetic navigation,photoimmunotherapy,tumor immune microenvironment ]

• RETRACTED: Extracellular Vesicles Embedded with Persistent Luminescence Nanoparticles Exhibiting Near-Infrared Emission for Long-Term Tracking in Primary Tumors
  ACS Applied Optical Materials, 2, 8, 1474-1487, 2024-08-23
  [ diagnosis,extracellular vesicles,long-term tracking,near-infrared persistent luminescence nanoparticles,tumor homing ]

• Quetiapine Significantly Improves the Effectiveness of Radiotherapy in Combating Hepatocellular Carcinoma Progression in a Hep3B Xenograft Mouse Model
  In Vivo, 38, 3, 1079-1093, 2024-05-01
  [ EGFR,hepatocellular carcinoma,Quetiapine,radiosensitizer,radiotherapy ]

• Atrophy of the cholinergic regions advances from early to late mild cognitive impairment
  Neuroradiology, 66, 4, 543-556, 2024-04-01
  [ APOE-ε4 allele,cholinergic pathway,Early mild cognitive impairment (EMCI),mild cognitive impairment (MCI),nucleus basalis of Meynert ]

• Lenvatinib Suppresses Protein Kinase B Signaling and Induces Apoptosis in Osteosarcoma Cells
  Anticancer Research, 44, 1, 85-92, 2024-01-01
  [ AKT,apoptosis,invasion,Lenvatinib,osteosarcoma ]

• Interplay between lncRNA RP11-367G18.1 variant 2 and YY1 plays a vital role in hypoxia-mediated gene expression and tumorigenesis
  Cancer Cell International, 23, 1, 2023-12-01
  [ Hypoxia,lncRNA RP11-367G18.1 variant 2,YY1 ]

• Clinical Effect of Moisturized Skin Care on Radiation Dermatitis of Head and Neck Cancer
  In Vivo, 37, 6, 2776-2785, 2023-11-01

• Unveiling nature's potential weapon: Magnolol's role in combating bladder cancer by upregulating the miR-124 and inactivating PKC-δ/ERK axis
  Phytomedicine, 119, 2023-10-01
  [ Bladder cancer,ERK,Magnolol,miR-124-3p,NF-κB,PKCδ ]

• Humanized PD-1 Knock-in Mice Reveal Nivolumab’s Inhibitory Effects on Glioblastoma Tumor Progression In Vivo
  In Vivo, 37, 5, 1991-2000, 2023-09-01
  [ cytotoxic T cells,Glioblastoma,humanized PD-1 knock-in mouse,immune microenvironment,nivolumab ]

• Imipramine Suppresses Tumor Growth and Induces Apoptosis in Oral Squamous Cell Carcinoma: Targeting Multiple Processes and Signaling Pathways
  Anticancer Research, 43, 9, 3987-3996, 2023-09-01
  [ anti-depressants,drug repurposing,Imipramine,oral squamous cell carcinoma,SASbearing mice ]

• Fluoxetine inactivates STAT3/NF-κB signaling and promotes sensitivity to cisplatin in bladder cancer
  Biomedicine and Pharmacotherapy, 164, 2023-08-01
  [ Apoptosis,Fluoxetine,Muscles invasive bladder cancer,NF-κB,STAT3 ]

• Imipramine Induces Apoptosis and Inhibits the Metastatic Potential of Triple-negative Breast Cancer Cells
  Anticancer Research, 47, 3, 2985-2994, 2023-07-01
  [ apoptosis,Imipramine,metastasis,triple-negative breast cancer ]

• In Reply to Yeh et al.
  International Journal of Radiation Oncology Biology Physics, 116, 3, 696-697, 2023-07-01

• Inactivation of EGFR/ERK/NF-κB signalling associates with radiosensitizing effect of 18β-glycyrrhetinic acid on progression of hepatocellular carcinoma
  Journal of Cellular and Molecular Medicine, 27, 11, 1539-1549, 2023-06-01
  [ 18β-Glycyrrhetinic acid,epidermal growth factor receptor,ERK,hepatocellular carcinoma,NF-κB,radiotherapy ]

• Accessing Apoptosis Induction and Metastasis Inhibition Effect of Magnolol on Triple Negative Breast Cancer In Vitro
  In Vivo, 37, 3, 1028-1036, 2023-05-01
  [ EGFR/JAK/STAT3,extrinsic/ intrinsic apoptosis,magnolol,metastasis,Triple-negative breast cancer ]

• Amentoflavone induces caspase-dependent/−independent apoptosis and dysregulates cyclin-dependent kinase-mediated cell cycle in colorectal cancer in vitro and in vivo
  Environmental Toxicology, 38, 5, 1078-1089, 2023-05-01
  [ amentoflavone,caspase-dependent apoptosis,caspase-independent apoptosis,colorectal cancer,cyclin-dependent kinase,G1 arrest ]

• Fluoxetine Inhibits STAT3-mediated Survival and Invasion of Osteosarcoma Cells
  Anticancer Research, 43, 3, 1193-1199, 2023-03-01
  [ angiogenesis,Fluoxetine,metastasis,osteosarcoma,STAT3 ]

• Lenvatinib Synergistically Promotes Radiation Therapy in Hepatocellular Carcinoma by Inhibiting Src/STAT3/NF-κB-Mediated Epithelial–Mesenchymal Transition and Metastasis
  International Journal of Radiation Oncology Biology Physics, 115, 3, 719-732, 2023-03-01

• Unlocking Synergistic Potential: Enhancing Regorafenib Efficacy in Hepatocellular Carcinoma Through Combination Therapy With 18β-Glycyrrhetinic Acid
  Anticancer Research, 43, 10, 4403-4412, 2023-01-01
  [ 18β-glycyrrhetinic acid,apoptosis,Hepatocellular carcinoma,mTOR,regorafenib ]

• A Novel Isotope-labeled Small Molecule Probe CC12 for Anti-glioma via Suppressing LYN-mediated Progression and Activating Apoptosis Pathways
  International Journal of Biological Sciences, 19, 10, 3209-3225, 2023-01-01
  [ Anthraquinone,CC12,Epithelial-mesenchymal transition,Glioblastoma,LYN,Metastasis ]

• Hyperforin Suppresses Oncogenic Kinases and Induces Apoptosis in Colorectal Cancer Cells
  In Vivo, 37, 1, 182-189, 2023-01-01
  [ AKT,apoptosis,colorectal cancer cells,ERK,Hyperforin,JAK1,oncogenic kinases,STAT3 ]

• Iron oxide@chlorophyll clustered nanoparticles eliminate bladder cancer by photodynamic immunotherapy-initiated ferroptosis and immunostimulation
  Journal of Nanobiotechnology, 20, 1, 2022-12-01

• Allyl Isothiocyanate (AITC) Induces Apoptotic Cell Death In Vitro and Exhibits Anti-Tumor Activity in a Human Glioblastoma GBM8401/luc2 Model
  International Journal of Molecular Sciences, 23, 18, 2022-09-01
  [ AITC,apoptosis,caspase,glioblastoma GBM8401/luc2 cancer cells,xenograft ]

• Magnolol Suppresses ERK/NF-ĸB Signaling and Triggers Apoptosis Through Extrinsic/Intrinsic Pathways in Osteosarcoma
  Anticancer Research, 42, 9, 4403-4410, 2022-09-01
  [ apoptosis,ERK,Magnolol,NF-ĸB,osteosarcoma ]

• Magnolol Induces Apoptosis Through Extrinsic/intrinsic Pathways and Attenuates NF-ĸB/STAT3 Signaling in Non-small-cell Lung Cancer Cells
  Anticancer Research, 42, 8, 3825-3833, 2022-08-01
  [ Magnolol,NF-ĸB,non-small-cell lung cancer,nuclear factor kappa B,signal transducer and activator of transcription 3,STAT3 ]

• STAT3 Inactivation and Induction of Apoptosis Associate With Fluoxetine-inhibited Epithelial-mesenchymal Transition and Growth of Triple-negative Breast Cancer In Vivo
  Anticancer Research, 42, 8, 3807-3814, 2022-08-01
  [ apoptosis,epithelial-to-mesenchymal transition,Fluoxetine,STAT3,triple-negative breast cancer ]

• DNA damage and NF-κB inactivation implicate glycyrrhizic acid-induced G1 phase arrest in hepatocellular carcinoma cells
  Journal of Food Biochemistry, 46, 7, 2022-07-01
  [ DNA damage,G1 arrest,glycyrrhizic acid,hepatocellular carcinoma cells,NF-κB ]

• Inactivation of AKT/ERK Signaling and Induction of Apoptosis Are Associated with Amentoflavone Sensitization of Hepatocellular Carcinoma to Lenvatinib
  Anticancer Research, 42, 5, 2495-2505, 2022-05-01
  [ AKT,Amentoflavone,ERK,hepatocellular carcinoma,lenvatinib ]

• Reinforcement of Sorafenib Anti-osteosarcoma Effect by Amentoflavone Is Associated With the Induction of Apoptosis and Inactivation of ERK/NF-κB
  In Vivo, 36, 3, 1136-1143, 2022-05-01
  [ Amentoflavone,apoptosis,ERK,NF-κB ]

• Synergistic effect of Abraxane that combines human IL15 fused with an albumin-binding domain on murine models of pancreatic ductal adenocarcinoma
  Journal of Cellular and Molecular Medicine, 26, 7, 1955-1968, 2022-04-01
  [ albumin-binding domain,interleukin-15,Nab-paclitaxel (Abraxane),pancreatic adenocarcinoma,tumour microenvironment ]

• Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma
  Neurotherapeutics, 19, 2, 616-634, 2022-03-01
  [ CXCR4/CXCL12,Glioblastoma,NF-κB,Regorafenib,Temozolomide ]

• Regorafenib enhances antitumor immune efficacy of anti-PD-L1 immunotherapy on oral squamous cell carcinoma
  Biomedicine and Pharmacotherapy, 147, 2022-03-01
  [ Anti-PD-L1,Antitumor-induced immunity,Oral squamous cells carcinoma,Regorafenib ]

• Bisdemethoxycurcumin Induces Cell Apoptosis and Inhibits Human Brain Glioblastoma GBM 8401/Luc2 Cell Xenograft Tumor in Subcutaneous Nude Mice In Vivo
  International Journal of Molecular Sciences, 23, 1, 2022-01-01
  [ Apoptosis,BAX,Bcl-2,BDMC,Glioblastoma (GBM) 8401/luc2 cells,Xenograft ]

• Revealing the suppressive role of protein kinase C delta and p38 mitogen-activated protein kinase (MAPK)/NF-κB axis associates with lenvatinib-inhibited progression in hepatocellular carcinoma in vitro and in vivo
  Biomedicine and Pharmacotherapy, 145, 2022-01-01
  [ Hepatocellular carcinoma,Lenvatinib,NF-ĸB,p38 MAPK,PKC-δ ]

• The inhibitory effect and mechanism of quetiapine on tumor progression in hepatocellular carcinoma in vivo
  Environmental Toxicology, 37, 1, 92-100, 2022-01-01
  [ ERK,hepatocellular carcinoma,NF-κB,quetiapine ]

• Magnolol Induces the Extrinsic/Intrinsic Apoptosis Pathways and Inhibits STAT3 Signaling-Mediated Invasion of Glioblastoma Cells
  Life, 11, 12, 2021-12-01
  [ Apoptosis,GBM,Invasion,Magnolol,STAT3 ]

• Tetrandrine suppresses human brain glioblastoma gbm 8401/luc2 cell-xenografted subcutaneous tumors in nude mice in vivo
  Molecules, 26, 23, 2021-12-01
  [ Human brain glioblastoma GBM 8401/luc2 cells,In vivo,Nude mice,Tetrandrine (TET),Xenograft tumor ]

• In Situ Formation of Au-Glycopolymer Nanoparticles for Surface-Enhanced Raman Scattering-Based Biosensing and Single-Cell Immunity
  ACS applied materials & interfaces, 13, 44, 52295-52307, 2021-11-10
  [ biosensing,glycopolymer gold nanoparticles,macrophage polarization,single-cell detection,surface-enhanced Raman scattering ]

• Suppression of EGFR/PKC-δ/NF-κB Signaling Associated With Imipramine-Inhibited Progression of Non-Small Cell Lung Cancer
  Frontiers in Oncology, 11, 2021-10-26
  [ EGFR - epidermal growth factor receptor,imipramine,NF-κB – nuclear factor kappa B,non-small cell lung cancer (NSCLC),PKC-δ-Protein kinase C delta ]

• Induction of apoptosis and inhibition of egfr/nf-κb signaling are associated with regorafenib-sensitized non-small cell lung cancer to cisplatin
  In Vivo, 35, 5, 2569-2576, 2021-10-01
  [ Cisplatin,EGFR,NF-κB,Non-small cell lung cancer,Regorafenib ]

• Lenvatinib induces AKT/NF-κB inactivation, apoptosis signal transduction and growth inhibition of non-small cell lung cancer in vivo
  Anticancer Research, 41, 6, 2867-2874, 2021-06-01
  [ AKT,Lenvatinib,NF-κB,Non-small cell lung cancer ]

• Demethoxycurcumin suppresses human brain glioblastoma multiforme gbm 8401 cell xenograft tumor in nude mice in vivo
  International Journal of Molecular Sciences, 22, 11, 2021-06-01
  [ Demethoxycurcumin (DMC),Glioblastoma multiforme,In vivo,Nude mice,Xenograft tumor ]

• Induction of apoptosis, inhibition of mcl-1, and vegf-a expression are associated with the anti-cancer efficacy of magnolol combined with regorafenib in hepatocellular carcinoma
  Cancers, 13, 9, 2021-05-01
  [ Apoptosis,Hepatocellular carcinoma,Magnolol,MCL-1,Regorafenib,VEGF-A ]

• Preclinical evaluation of recombinant human IL15 protein fused with albumin binding domain on anti-PD-L1 immunotherapy efficiency and anti-tumor immunity in colon cancer and melanoma
  Cancers, 13, 8, 2021-04-02
  [ Colon cancer,IL15,Melanoma,PD-L1,Tumor microenvironment ]

• Amentoflavone induces cell-cycle arrest, apoptosis, and invasion inhibition in non-small cell lung cancer cells
  Anticancer Research, 41, 3, 1357-1364, 2021-03-01
  [ Amentoflavone,Apoptosis,Invasion,Non-small cell lung cancer,Nuclear factor-kappa B ]

• Sorafenib induces apoptosis and inhibits NF-ĸB-mediated anti-apoptotic and metastatic potential in osteosarcoma cells
  Anticancer Research, 41, 3, 1251-1259, 2021-03-01
  [ Apoptosis,Metastatic potential,NF-ĸB,Osteosarcoma,Sorafenib ]

• Article evaluation of the swallow-tail sign and correlations of neuromelanin signal with susceptibility and relaxations
  Tomography (Ann Arbor, Mich.), 7, 2, 107-119, 2021-01-01
  [ Nigrosome-1,Susceptibility-weighted imaging,Swallow-tail sign ]

• Lenvatinib inhibits AKT/NF-κB signaling and induces apoptosis through extrinsic/intrinsic pathways in non-small cell lung cancer
  Anticancer Research, 41, 1, 123-130, 2021-01-01
  [ AKT,Apoptosis,Lenvatinib,NF-κB,Non-small cell lung cancer ]

• Anticancer efficacy and mechanism of amentoflavone for sensitizing oral squamous cell carcinoma to cisplatin
  Anticancer Research, 40, 12, 6723-6732, 2020-12-01
  [ Amentoflavone,Apoptosis,Cisplatin,NF-ĸB,Oral squamous cell carcinoma ]

• Therapeutic Efficacy and Inhibitory Mechanism of Regorafenib Combined with Radiation in Colorectal Cancer
  In Vivo, 34, 6, 3217-3224, 2020-11-01
  [ Apoptosis,NF-ĸB,Radiosensitizing effect,Radiotherapy ]

• Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits EGFR/ERK/NF-κB-mediated anti-apoptotic potential in glioblastoma
  Environmental Toxicology, 35, 10, 1058-1069, 2020-10-01
  [ EGFR,ERK,glioblastoma,hyperforin,NF-κB ]

• ERK/AKT inactivation and apoptosis induction associate with quetiapine-inhibited cell survival and invasion in hepatocellular carcinoma cells
  In Vivo, 34, 5, 2407-2417, 2020-09-01
  [ Apoptosis,ERK/AKT activation,Hepatocellular carcinoma,Quetiapine ]

• The in Vivo Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma
  In Vivo, 34, 4, 1789-1796, 2020-08-01
  [ Apoptosis,Hepatocellular carcinoma,Magnolol,Radiation ]

• Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer
  Biomedicine and Pharmacotherapy, 128, 2020-08-01
  [ Colon rectal cancer,Epidermal growth factor receptors,NF-κB,PKC-δ,Regorafenib ]

• Beneficial effect of fluoxetine on anti-tumor progression on hepatocellular carcinoma and non-small cell lung cancer bearing animal model
  Biomedicine and Pharmacotherapy, 126, 2020-06-01
  [ AKT,ERK,Fluoxetine,HCC,NF-κB,NSCLC ]

• Suppression of pkcδ/nf-κb signaling and apoptosis induction through extrinsic/intrinsic pathways are associated magnolol-inhibited tumor progression in colorectal cancer in vitro and in vivo
  International Journal of Molecular Sciences, 21, 10, 2020-05-02
  [ Apoptosis,Colorectal cancer,Magnolol,NF-κB,PKCδ ]

• Induction of apoptosis through extrinsic/intrinsic pathways and suppression of ERK/NF-κB signalling participate in anti-glioblastoma of imipramine
  Journal of Cellular and Molecular Medicine, 24, 7, 3982-4000, 2020-04-01
  [ ERK,extrinsic/intrinsic apoptosis,glioblastoma,imipramine,NF-κB ]

• Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma in vivo
  Environmental Toxicology, 35, 2, 167-175, 2020-02-01
  [ ERK,HCC,magnolol,NF-κB ]

• Astragaloside IV induces apoptosis, G1-phase arrest and inhibits anti-apoptotic signaling in hepatocellular carcinoma
  In Vivo, 34, 2, 631-638, 2020-01-01
  [ Anti-apoptotic,Apoptosis,Astragaloside IV,G1 arrest,Hepatocellular carcinoma ]

• Glycyrrhizic Acid Modulates Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits Protein Kinase B- And Extracellular Signal-Regulated Kinase-Mediated Metastatic Potential in Hepatocellular Carcinoma in Vitro and in Vivo
  American Journal of Chinese Medicine, 48, 1, 223-244, 2020-01-01
  [ AKT,ERK,Extrinsic Apoptosis,Glycyrrhizic Acid,HCC,Intrinsic Apoptosis ]

• Protein kinase B inactivation is associated with magnolol-enhanced therapeutic efficacy of sorafenib in hepatocellular carcinoma in vitro and in vivo
  Cancers, 12, 1, 2020-01-01
  [ AKT,Hepatocellular carcinoma,Magnolol,Sorafenib ]

• Apoptosis induction and AKT/NF-κB inactivation are associated with regroafenib-inhibited tumor progression in non-small cell lung cancer in vitro and in vivo
  Biomedicine and Pharmacotherapy, 116, 2019-08-01
  [ AKT,Apoptosis,NF-κB,Non-small cell lung cancer,Regorafenib ]

• Protein kinase b and extracellular signal-regulated kinase inactivation is associated with regorafenib-induced inhibition of osteosarcoma progression in vitro and in vivo
  Journal of Clinical medicine, 8, 6, 2019-06-01
  [ AKT,ERK,Osteosarcoma,Regorafenib ]

• Cellular Magnetic Resonance Imaging with Superparamagnetic Iron Oxide: Methods and Applications in Cancer
  SPIN, 9, 2, 2019-06-01
  [ cancer, mesenchymal stem cell,magnetic resonance imaging,Superparamagnetic iron oxide,theranostics ]

• Regorefenib induces extrinsic/intrinsic apoptosis and inhibits MAPK/NF-κB-modulated tumor progression in bladder cancer in vitro and in vivo
  Environmental Toxicology, 34, 6, 679-688, 2019-06-01
  [ apoptosis,bladder cancer,MAPK,NF-κB,regorafenib ]

• Hyperforin Induces Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits NF-ĸB-modulated Survival and Invasion Potential in Bladder Cancer
  In Vivo, 33, 6, 1865-1877, 2019-01-01
  [ Apoptosis,Bladder cancer,Calcium signalling,Cytosol ROS,Hyperforin,NF-κB,P65 ]

• Amentoflavone induces apoptosis and reduces expression of anti-apoptotic and metastasis-associated proteins in bladder cancer
  Anticancer Research, 39, 7, 3641-3649, 2019-01-01
  [ Amentoflavone,Anti-apoptotic,Extrinsic apoptosis,Intrinsic apoptosis,Metastasis ]

• Suppression of ERK/NF-ĸB activation ιs associated with amentoflavone-inhibited osteosarcoma progression in vivo
  Anticancer Research, 39, 7, 3669-3675, 2019-01-01
  [ Amentoflavone,ERK,NF-ĸB,Osteosarcoma ]

• Amentoflavone Effectively Blocked the Tumor Progression of Glioblastoma via Suppression of ERK/NF- κ B Signaling Pathway
  American Journal of Chinese Medicine, 47, 4, 913-931, 2019-01-01
  [ Amentoflavone,Anticancer,ERK,Glioblastoma,NF- κ B ]

• Fluoxetine induces apoptosis through extrinsic/intrinsic pathways and inhibits ERK/NF-κB-modulated anti-apoptotic and invasive potential in hepatocellular carcinoma cells in vitro
  International Journal of Molecular Sciences, 20, 3, 2019-01-01
  [ Apoptosis,Fluoxetine,Human hepatocellular carcinoma,NF-κB ]

• Enhanced cytotoxicity of human hepatocellular carcinoma cells following pretreatment with sorafenib combined with trichostatin A
  Oncology Letters, 17, 1, 638-645, 2019-01-01
  [ Extracellular-signal-regulated kinase,Hepatocellular carcinoma,Nuclear factor-κB,Sorafenib,Trichostatin A ]

• MRI tracking of polyethylene glycol-coated superparamagnetic iron oxide-labelled placenta-derived mesenchymal stem cells toward glioblastoma stem-like cells in a mouse model
  Artificial Cells, Nanomedicine and Biotechnology, 46, sup3, S448-S459, 2018-11-12
  [ cellular MRI,Glioblastoma stem-like cells,mesenchymal stem cell tumor-homing,placenta-derived mesenchymal stem cells,polyethylene glycol–coated superparamagnetic iron oxide ]

• Magnolol induces apoptosis and inhibits ERK-modulated metastatic potential in hepatocellular carcinoma cells
  In Vivo, 32, 6, 1361-1368, 2018-11-01
  [ Apoptosis,Extracellular-signal-regulated kinase,Hepatocellular carcinoma,Magnolol ]

• Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo
  Environmental Toxicology, 33, 11, 1097-1104, 2018-11-01
  [ benzyl isothiocyanate,human brain glioblastoma multiforme GBM 8401 cell,in vivo,nude mice,xenograft tumor ]

• Machine learning–based radiomics for molecular subtyping of gliomas
  Clinical Cancer Research, 24, 18, 4429-4436, 2018-09-15

• Phenethyl isothiocyanate inhibits in vivo growth of xenograft tumors of human glioblastoma cells
  Molecules, 23, 9, 2018-09-10
  [ Apoptosis,Caspase,Glioblastoma,Phenethyl isothiocyanate,Xenograft ]

• Amentoflavone inhibits hepatocellular carcinoma progression through blockage of ERK/NF-κB activation
  In Vivo, 32, 5, 1097-1103, 2018-09-01
  [ Amentoflavone,Bioluminescence imaging,Extracellular signal-regulated kinase,Hepatocellular carcinoma,Nuclear factor-kappaB ]

• Fluoxetine inhibits DNA repair and NF-ĸB-modulated metastatic potential in non-small cell lung cancer
  Anticancer Research, 38, 9, 5201-5210, 2018-09-01
  [ DNA repair,Fluoxetine,Metastatic potential,NF-ĸB,Non-small cell lung cancer ]

• Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice
  Bioscience Reports, 38, 3, 2018-05-08

• Amentoflavone inhibits ERK-modulated tumor progression in hepatocellular carcinoma in vitro
  In Vivo, 32, 3, 549-554, 2018-05-01
  [ Amentoflavone,ERK,Hepatocellular carcinoma,NF-?B ]

• Serum amyloid A1 in combination with integrin αVβ3 increases glioblastoma cells mobility and progression
  Molecular Oncology, 12, 5, 756-771, 2018-05-01
  [ glioblastoma multiform,integrin αVβ3,invasion,metastasis,serum amyloid A1 ]

• Amentoflavone enhances the therapeutic efficacy of sorafenib by inhibiting anti-apoptotic potential and potentiating apoptosis in hepatocellular carcinoma in vivo
  Anticancer Research, 38, 4, 2119-2125, 2018-04-01
  [ AKT,Amentoflavone,Apoptosis.,ERK,Hepatocellular carcinoma,Sorafenib ]

• Hyperforin suppresses tumor growth and NF-ĸB-mediated anti-apoptotic and invasive potential of non-small cell lung cancer
  Anticancer Research, 38, 4, 2161-2167, 2018-04-01
  [ Apoptosis,Hyperforin,Invasion.,NF-ĸB,Non-small cell lung cancer ]

• Assessing the selective therapeutic efficacy of superparamagnetic erlotinib nanoparticles in lung cancer by using quantitative magnetic resonance imaging and a nuclear factor kappa-B reporter gene system
  Nanomedicine: Nanotechnology, Biology, and Medicine, 14, 3, 1019-1031, 2018-04-01
  [ Erlotinib,Magnetic resonance imaging,Non-small-cell lung cancer,Nuclear factor-κB,Superparamagnetic iron oxide ]

• Histogram analysis of T2*-based pharmacokinetic imaging in cerebral glioma grading
  Computer Methods and Programs in Biomedicine, 155, 19-27, 2018-03-01
  [ Cerebral glioma,Histogram analysis,Permeability imaging,Tumor grading ]

• Amentoflavone induces apoptosis and inhibits nf-ĸb-modulated anti-apoptotic signaling in glioblastoma cells
  In Vivo, 32, 2, 279-285, 2018-01-01
  [ Amentoflavone,And NF-ĸB,Apoptosis,Glioblastoma ]

• Identification of epidermal growth factor receptor-positive glioblastoma using lipid-encapsulated targeted superparamagnetic iron oxide nanoparticles in vitro
  Journal of Nanobiotechnology, 15, 1, 2017-11-22
  [ Epidermal growth factor receptor (EGFR),Glioblastoma,Lipid-encapsulated nanoparticle,Magnetic resonance imaging (MRI),Targeted superparamagnetic iron oxide (SPIO) nanoparticle ]

• Regorafenib induces apoptosis and inhibits metastatic potential of human bladder carcinoma cells
  Anticancer Research, 37, 9, 4919-4926, 2017-09-01
  [ Apoptosis,Human bladder carcinoma,Metastatic potential,Regorafenib ]

• Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells
  Oncology Reports, 37, 2, 1036-1044, 2017-02-01
  [ ERK/NF-κB,Hepatocellular carcinoma,Regorafenib ]

• Amentoflavone enhances sorafenib-induced apoptosis through extrinsic and intrinsic pathways in sorafenib-resistant hepatocellular carcinoma SK-hep1 cells in vitro
  Oncology Letters, 14, 3, 3229-3234, 2017-01-01
  [ Amentoflavone,Apoptosis,Hepatocellular carcinoma,Resistance,Sorafenib ]

• Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI
  Scientific Reports, 6, 2016-11-11

• Inhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplex
  Journal of Nanobiotechnology, 14, 1, 2016-02-19
  [ Breast cancer,Lipo-PEG-PEI complex,Tamoxifen,Transdermal treatment ]

• Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model
  Oncotarget, 7, 51, 85450-85463, 2016-01-01
  [ Hepatocellular carcinoma,MEK/ERK/NF-κB signaling,Molecular imaging,Radiation,Sorafenib ]

• Synergistic Effect of Sorafenib and Radiation on Human Oral Carcinoma in vivo
  Scientific Reports, 5, 2015-10-21

• Enhancement of adoptive T cell transfer with single low dose pretreatment of doxorubicin or paclitaxel in mice
  Oncotarget, 6, 42, 44134-44150, 2015-01-01
  [ Adoptive T cell transfer,Bioluminescent imaging,Doxorubicin,Immune response,Immunity,Immunology and microbiology section,Immunomodulation,NF-kB,Paclitaxel ]

• Curcumin Sensitizes Hepatocellular Carcinoma Cells to Radiation via Suppression of Radiation-Induced NF-κB Activity
  BioMed Research International, 2015, 2015-01-01

• Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway
  International Journal of Molecular Medicine, 34, 5, 1417-1422, 2014-11-01
  [ Autophagy,Everolimus,Radiosensitization,Ras ]

• Synergistic effect of sorafenib with ionizing radiation on human oral cancer cells
  In Vivo, 28, 5, 925-934, 2014-09-01
  [ Human oral squamous cell carcinoma,NF-κB,Radiation,Sorafenib ]

• Curcumin synergistically enhances the radiosensitivity of human oral squamous cell carcinoma via suppression of radiation-induced NF-κB activity
  Oncology Reports, 31, 4, 1729-1737, 2014-01-01
  [ Curcumin,Nuclear factor-κB,Radiotherapy ]

• Sorafenib increases efficacy of vorinostat against human hepatocellular carcinoma through transduction inhibition of vorinostat-induced ERK/NF-κB signaling
  International Journal of Oncology, 45, 1, 177-188, 2014-01-01
  [ Hepatocellular carcinoma,NF-κB,SAHA,Sorafenib,Vorinostat ]

• Simultaneous imaging of temporal changes of NF-κB activity and viable tumor cells in Huh7/NF-κB-tk-luc2/rfp tumor-bearing mice
  In Vivo, 27, 3, 339-350, 2013-01-01
  [ Human hepatocellular carcinoma,Imaging,RFP,Sorafenib,Temporal NF-κB monitoring ]

• Using NF-κB as a molecular target for theranostics in radiation oncology research
  Expert Review of Molecular Diagnostics, 12, 2, 139-146, 2012-03-01
  [ chemoresistance,IKK inhibitor,molecular targeting,nanoparticle,NF-kB,radioresistance,sorafenib ]

• Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-κB pathway in hepatocellular carcinoma cells
  In Vivo, 26, 4, 671-682, 2012-01-01
  [ Hepatocellular carcinoma,Huh 7 cells,MMP-9,NF-κB,Sorafenib,VEGF ]

• Decrease in breast density in the contralateral normal breast of patients receiving neoadjuvant chemotherapy: MR imaging evaluation
  Radiology, 255, 1, 44-52, 2010-04-01

• Does breast density show difference in patients with estrogen receptor-positive and estrogen receptor-negative breast cancer measured on MRI?
  Annals of Oncology, 20, 8, 1447-1449, 2009-10-01

• Comparison of breast density in the contralateral normal breast of patients with invasive and in situ breast cancer measured on MRI
  Annals of Oncology, 20, 8, 1449-1450, 2009-01-01

研討會著作

• Investigate the Anticancer Immunomodulation Mechanism of Fluoxetine Treatment in Oral Squamous Cell Carcinoma
  2025-06-18
  [ Oral squamous cell carcinoma,Fluoxetine,Tumor microenvironment,Immune checkpoint inhibitor ]

• Evaluation of Therapeutic Efficacy of Magnolol Combined with Radiation in Non-small Cell Lung Cancer
  2025-06-18
  [ Magnolol,Radiation Therapy,Non-Small Cell Lung Cancer,Apoptosis,DNA Damage Repair ]

• Evaluation of the Therapeutic Efficacy and Immunomodulatory Effects of Iron Oxide-Conjugated Photosensitizer Nanoparticles in Glioblastoma
  2025-06-18
  [ Glioblastoma,Photodynamic therapy,Ferroptosis,Iron oxide ]

• Identify the efficacy and mechanism of engineering UMSC/miR-145-5p-TRAIL and its derived exosome on hepatocellular carcinoma
  2025-06-17
  [ Hepatocellular carcinoma,Umbilical cord mesenchymal stem cells,miR-145-5p,TNF-related apoptosis-inducing ligand (TRAIL) ]

• Evaluating the role of ATM inhibitors in enhancing the efficacy of radiotherapy and their potential to improve the immunosuppressive microenvironment of glioblastoma.
  2025-06-17
  [ Glioblastoma,Radiotherapy,ATM inhibitor,Tumor microenvironment ]

• Evaluate the potential sensitization effect and underlying mechanism of tyrosine kinase inhibitor on cisplatin resistance oral squamous cell carcinoma
  2025-06-17
  [ Oral squamous cell carcinoma,Tyrosine kinase inhibitors,cisplatin,HIF-1α/VEGF/BCL-2 ]