教師個人簡歷
現職
國立中央大學
理學院光電科學與工程學系
教授
專長
物理-軟物質及生物物理
化學-生物物理化學
光電工程-生醫光電
光電工程-光學工程
Physics-soft matter and biophysics
chemistry-biophysical chemistry
optoelectronic engineering-biomedical optoelectronics
optoelectronic engineering-optical engineering
專長簡述
光學生醫影像資訊、單分子生物物理、電漿子光學雷射光譜
最高學歷
國立中央大學
光電科學研究所
博士
科技部學門領域
政府GRB研究專長領域
教育部學門領域
國科會計畫統計
-
具深度學習之單分子顯微術於類澱粉蛋白超結構分析之研究
1160101~1161231
-
具深度學習之單分子顯微術於類澱粉蛋白超結構分析之研究
1150101~1151231
-
以多光子激發單分子體積造影平台探索病理組織內空間蛋白體學分析之研究(1/3)
1140801~1150731
-
具深度學習之單分子顯微術於類澱粉蛋白超結構分析之研究
1140101~1141231
-
以具深度學習之大面積多光子激發單分子影像與聯合療法於阿茲海默症的協同效應之研究(3/3)
1130801~1150228
-
以具深度學習之大面積多光子激發單分子影像與聯合療法於阿茲海默症的協同效應之研究(2/3)
1120801~1140531
[阿茲海默症,β-澱粉樣蛋白,tau蛋白,深度學習,線掃描時域聚焦多光子激發,單分子定位顯微術,擴展樣品,定量數據分析 , Alzheimer’s disease,amyloid-β,tau,deep learning,line-scanning temporalfocusing multiphoton excitation,single-molecule localization microscopy,expansion specimen, quantitative data analysis,quantitative data analysis] -
以具深度學習之大面積多光子激發單分子影像與聯合療法於阿茲海默症的協同效應之研究(1/3)
1110801~1130131
[阿茲海默症,β-澱粉樣蛋白,tau蛋白,深度學習,線掃描時域聚焦多光子激發,單分子定位顯微術,擴展樣品,定量數據分析 , Alzheimer’s disease,amyloid-β,tau,deep learning,line-scanning temporalfocusing multiphoton excitation,single-molecule localization microscopy,expansion specimen,quantitative data analysis] -
深組織多色單分子影像資訊與治療性奈米載體於神經退化性疾病之研究(3/3)
1100801~1120131
[單分子定位顯微術、時域聚焦多光子激發、單分子偵測、適應性光學、深組織多色 造影、光譜量測、三維顯微術、b類澱粉蛋白、tau蛋白病理、奈米載體、神經退化 性疾病、精準治療 , single-molecule localization microscopy, temporal focusing multiphoton excitation, single-molecule detection, adaptive optics, deep-tissue multicolor imaging, spectral measurement, three-dimensional microscopy, beta-amyloid, tau pathology, nanocarriers, neurodegenerative disease, precision treatment] -
深組織多色單分子影像資訊與治療性奈米載體於神經退化性疾病之研究(2/3)
1090801~1110131
[單分子定位顯微術、時域聚焦多光子激發、單分子偵測、適應性光學、深組織多色 造影、光譜量測、三維顯微術、b類澱粉蛋白、tau蛋白病理、奈米載體、神經退化 性疾病、精準治療 , single-molecule localization microscopy, temporal focusing multiphoton excitation, single-molecule detection, adaptive optics, deep-tissue multicolor imaging, spectral measurement, three-dimensional microscopy, beta-amyloid, tau pathology, nanocarriers, neurodegenerative disease, precision treatment.] -
深組織多色單分子影像資訊與治療性奈米載體於神經退化性疾病之研究( 1/3)
1080801~1091231
[單分子定位顯微術,時域聚焦多光子激發,單分子偵測,適應性光學,深組織多色造影,光譜量測,三維顯微術,b類澱粉蛋白,tau蛋白病理,奈米載體,神經退化性疾病,精準治療 , single-molecule localization microscopy, temporal focusing multiphoton excitation, single-molecule detection, adaptive optics, deep-tissue multicolor imaging, spectral measurement, three-dimensional microscopy, beta-amyloid, tau pathology, nanocarriers, n] -
超解析度影像資訊於厚生物組織內分子功能分析之研究
1070801~1081231
[超解析度定位顯微術,三維顯微術,單分子偵測,時域聚焦多光子激發顯微術,上 皮細胞生長因子受體,非小細胞肺癌,突觸,神經元,大腦影像,神經退化性疾病 , super-resolution localization microscopy,three dimensional microscopy,single molecule detection,temporal focusing multiphoton excitation microscopy,epidermal growth factor] -
超解析度影像資訊於厚生物組織內分子功能分析之研究
1060801~1070731
[超解析度定位顯微術,三維顯微術,單分子偵測,時域聚焦多光子激發顯微術,上 皮細胞生長因子受體,非小細胞肺癌,突觸,神經元,大腦影像,神經退化性疾病 , super-resolution localization microscopy,three dimensional microscopy,single molecule detection,temporal focusing multiphoton excitation microscopy,epidermal growth factor] -
超解析度影像資訊於厚生物組織內分子功能分析之研究
1050801~1060731
[超解析度定位顯微術,三維顯微術,單分子偵測,時域聚焦多光子激發顯微術,上 皮細胞生長因子受體,非小細胞肺癌,突觸,神經元,大腦影像,神經退化性疾病 , super-resolution localization microscopy,three dimensional microscopy,single molecule detection,temporal focusing multiphoton excitation microscopy,epidermal growth factor] -
利用先進活細胞螢光顯微鏡影像技術探討細胞膜上JAK2 激酶活化及癌化的機轉-利用活細胞多色超解析度螢光定位顯微術鏡與配對分析做單分子定量分析(子計畫二)(3/3)
1040801~1051130
產學合作計畫統計
-
113年度秋季光電科學與工程學系光電產業碩士專班(英特盛)
1130401~1151130
[產碩專班 , 無] -
113年度秋季光電科學與工程學系光電產業碩士專班(英特盛)獎學金
1130401~1151130
[產碩專班 , 無] -
112年度秋季光電科學與工程學系光電產業碩士專班(春虹)
1120401~1141130
[產碩專班 , 無]
期刊著作
-
Unraveling the structure–activity relationships of organometallic ferrocene-pyrazole and ferrocene-pyrimidine curcumin analogues in amyloid-β aggregation and glioblastoma treatment
Scientific Reports, 15, 1, 2025-12-01
[ Amyloid aggregation,Ferrocenyl-pyrazole/pyrimidine-curcumin derivatives,Glioblastoma ] -
Single-Base Detection of DNA with Simplified Steps on InGaN Quantum Wells
Journal of Physical Chemistry B, 129, 18, 4366-4372, 2025-05-08 -
Hybrid-Free DNA Test by Band Engineering of Nitride Semiconductor and Machine Learning
ACS Applied Electronic Materials, 7, 8, 3255-3263, 2025-04-22
[ DNA,GaN,machine learning,quantum well,surface-enhanced Raman spectroscopy ] -
Temporal-Focusing Multiphoton Excitation Single-Molecule Localization Microscopy Using Spontaneously Blinking Fluorophores
Angewandte Chemie - International Edition, 63, 27, 2024-07-01
[ Amyloid-beta deposits,Single-molecule localization microscopy,Spontaneously blinking fluorophore,Temporal-focusing multiphoton excitation,Three-dimensional imaging ] -
Detecting glucose in a cell culture medium by surface-enhanced Raman scattering on InGaN quantum wells
Optics Continuum, 2, 12, 2509-2515, 2023-12-15 -
A Fluorescent Vector of Carbon Dot to Deliver Rab13 and Rab14 Plasmids for Promoting Neurite Outgrowth
ACS Applied Bio Materials, 6, 9, 3739-3749, 2023-09-18
[ carbon dots,fluorescence imaging probes,nanocarriers,neurite outgrowth,plasmid DNA delivery,Rab13,Rab14 ] -
Catching Single Molecules with Plasmonic InGaN Quantum Dots
Advanced Optical Materials, 11, 18, 2023-09-18
[ InGaN,quantum dots,single molecules,surface-enhanced Raman spectroscopy ] -
A two-photon fluorescence probe for cell membrane imaging under temporal-focusing multiphoton excitation microscopy (TFMPEM)
Chemical Communications, 57, 97, 13118-13121, 2021-12-18 -
Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization
Scientific Reports, 11, 1, 2021-12-01 -
Single-Molecule Blinking Fluorescence Enhancement by Surface Plasmon-Coupled Emission-Based Substrates for Single-Molecule Localization Imaging
Analytical Chemistry, 93, 46, 15401-15411, 2021-11-23 -
Controlling the Electron Concentration for Surface-Enhanced Raman Spectroscopy
ACS Photonics, 8, 8, 2410-2416, 2021-08-18
[ InGaN,MOCVD,quantum wells,surface-enhanced Raman spectroscopy ] -
Nanostructured InGaN Quantum Wells as a Surface-Enhanced Raman Scattering Substrate with Expanded Hot Spots
ACS Applied Nano Materials, 4, 3, 2614-2620, 2021-03-26
[ hot spots,InGaN,MOCVD,quantum well,SERS ] -
Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker
Biomaterials, 246, 2020-07-01
[ Antibody therapy , Mesoporous silica nanoparticles , NF-κB , Size hindrance , TAT peptide ] -
An excitation wavelength switching to enhance dual-color wide-field temporal-focusing multiphoton excitation fluorescence imaging
Journal Physics D: Applied Physics, 53, 23, 2020-06-03
[ dual-color,excitation wavelength switching,temporal-focusing multiphoton excitation microscopy,two-photon excitation spectrum ] -
Codelivery of Plasmid and Curcumin with Mesoporous Silica Nanoparticles for Promoting Neurite Outgrowth
ACS applied materials & interfaces, 11, 17, 15322-15331, 2019-05-01
[ codelivery , combining therapy , mesoporous silica nanoparticles , neurite growth , neurodegenerative diseases ] -
Simulation design of wide-field temporal-focusing multiphoton excitation with a tunable excitation wavelength
OSA Continuum, 2, 4, 1174-1187, 2019-04-15 -
Nitride-Based Microarray Biochips: A New Route of Plasmonic Imaging
ACS applied materials & interfaces, 10, 46, 39898-39903, 2018-11-21
[ biosensors , InGaN , local density of states , quantum wells , surface plasmon resonance ] -
Enhancing the blinking fluorescence of single-molecule localization imaging by using a surface-plasmon-polariton-enhanced substrate
Physical Chemistry Chemical Physics, 20, 43, 27245-27255, 2018-01-01 -
Horseradish peroxidase-encapsulated hollow silica nanospheres for intracellular sensing of reactive oxygen species
Nanoscale Research Letters, 13, 2018-01-01
[ Enzyme delivery , Hollow silica nanospheres , Horseradish peroxidase , Porous materials , Reactive oxygen species ] -
Two-color temporal focusing multiphoton excitation imaging with tunable-wavelength excitation
Journal of Biomedical Optics, 22, 2, 2017-02-01
[ temporal focusing multiphoton excitation microscopy , tunable-wavelength excitation , two-color fluorescence imaging ] -
Flexible nanopillars to regulate cell adhesion and movement
Nanotechnology, 27, 47, 2016-10-24
[ cell adhesion , cell migration , polymer nanopillar , protein pair-distance analysis , super-resolution localization microscopy ] -
Approach to Deliver Two Antioxidant Enzymes with Mesoporous Silica Nanoparticles into Cells
ACS applied materials & interfaces, 8, 28, 17944-17954, 2016-07-20
[ antioxidant enzyme , cascade reaction , codelivery , glutathione peroxidase , mesoporous silica nanoparticle , reactive oxygen species , superoxide dismutase ] -
Red phosphorescent trilayer organic light-emitting field-effect transistors with a wide recombination zone
Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes, 55, 2, 2016-02-01 -
Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1
PLoS Biology, 14, 1, 2016-01-11 -
Dual-color dynamic tracking of GM-CSF receptors/JAK2 kinases signaling activation using temporal focusing multiphoton fluorescence excitation and astigmatic imaging
, 23, 24, 30943-30955, 2015-11-30 -
Optimization of gold nanoparticle photoluminescence by alkanethiolation
Chemical Communications, 51, 37, 7954-7957, 2015-05-07 -
Local pH tracking in living cells
Nanoscale, 7, 9, 4217-4225, 2015-03-07 -
Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues
Organic and Biomolecular Chemistry, 13, 45, 11096-11104, 2015-01-01 -
Process dependence of morphology and microstructure of cyanine dye J-aggregate film: Correlation with absorption, photo- and electroluminescence properties
, 22, 24, 29388-29397, 2014-12-01 -
Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6
Glycobiology, 24, 11, 1022-1035, 2014-11-01
[ Alix , galectin-3 , HIV-1 , viral budding ] -
Nonlinear structured-illumination enhanced temporal focusing multiphoton excitation microscopy with a digital micromirror device
Biomedical Optics Express, 5, 8, 2526-2536, 2014-08-01 -
Characterization of the cleaning process on a transferred graphene
Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films, 32, 5, 2014-01-01 -
Dynamic particle tracking via temporal focusing multiphoton microscopy with astigmatism imaging
, 22, 22, 27290-27299, 2014-01-01 -
Hybrid contact and interfacial adhesion on well-defined periodic hierarchical pillars
Nanoscale, 5, 3, 1018-1025, 2013-02-07 -
Interfacial adhesion and superhydrophobicity modulated with polymeric nanopillars using integrated nanolithography
Journal of Micromechanics and Microengineering, 22, 12, 2012-12-01 -
Development of chitosan oligosaccharide-modified gold nanorods for in vivo targeted delivery and noninvasive imaging by NIR irradiation
Bioconjugate Chemistry, 23, 11, 2173-2182, 2012-11-21 -
Improving the light trapping efficiency of plasmonic polymer solar cells through photon management
Journal of Physical Chemistry C, 116, 39, 20731-20737, 2012-10-04 -
Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2
Cell Cycle, 11, 19, 3611-3626, 2012-10-01
[ Casein kinase 2 , Clathrin-coated pit , GM-CSF receptor , Jak2 , Myeloproliferative disorders ] -
Synthesis of tunable and multifunctional Ni-doped near-infrared QDs for cancer cell targeting and cellular sorting
Bioconjugate Chemistry, 23, 3, 421-430, 2012-03-21 -
Surface charge effect in intracellular localization of mesoporous silica nanoparticles as probed by fluorescent ratiometric pH imaging
RSC Advances, 2, 3, 968-973, 2012-02-07 -
Exploring the formation of focal adhesions on patterned surfaces using super-resolution imaging
Small, 7, 20, 2906-2913, 2011-10-17
[ cell adhesion , imaging , nanolithography , patterning , superresolution ] -
Investigation of the growth of focal adhesions using protein nanoarrays fabricated by nanocontact printing using size tunable polymeric nanopillars
Nanotechnology, 22, 26, 2011-07-01 -
Facile transfer method for fabricating light-harvesting systems for polymer solar cells
Journal of Physical Chemistry C, 115, 23, 11864-11870, 2011-06-16 -
Targeted nuclear delivery using peptide-coated quantum dots
Bioconjugate Chemistry, 22, 6, 1073-1080, 2011-06-15 -
Development of lipid targeting Raman probes for in vivo imaging of Caenorhabditis elegans
Chemistry - A European Journal, 17, 18, 5165-5170, 2011-04-26
[ fluorescence , lipids , nanoparticles , Raman probes , SERS imaging ] -
Localization imaging using blinking quantum dots
The Analyst, 136, 8, 1608-1613, 2011-04-21 -
Surface plasmonic effects of metallic nanoparticles on the performance of polymer bulk heterojunction solar cells
ACS Nano, 5, 2, 959-967, 2011-02-22
[ exciton lifetime , gold nanoparticles , photoluminescence , polymer photovoltaics , surface plasmon ] -
Polymeric nanopillar arrays for cell traction force measurements
Electrophoresis, 31, 18, 3152-3158, 2010-09-01
[ Focal adhesion , Nanopillar , Traction force ] -
Correlation between exciton lifetime distribution and morphology of bulk heterojunction films after solvent annealing
Journal of Physical Chemistry C, 114, 19, 9062-9069, 2010-05-20 -
Monitoring the 3D nanostructures of bulk heterojunction polymer solar cells using confocal lifetime imaging
Analytical Chemistry, 82, 5, 1669-1673, 2010-03-01 -
Revealing the spatial distribution of the site enhancement for the surface enhanced Raman scattering on the regular nanoparticle arrays
, 17, 16, 13974-13981, 2009-08-03 -
Annealing effect of polymer bulk heterojunction solar cells based on polyfluorene and fullerene blend
Organic Electronics, 10, 1, 27-33, 2009-01-01
[ Annealing effect , F8T2 , Photovoltaic device , Polymer ] -
White-light emission from an upconverted emission with an organic triplet sensitizer
Chemical Communications, 27, 4064-4066, 2009-01-01 -
Coupled waveguide-surface plasmon resonance biosensor with subwavelength grating
Biosensors and Bioelectronics, 22, 11, 2737-2742, 2007-05-15
[ Diffraction grating , Optical biosensor , Subwavelength structure , Surface plasmon resonance , Waveguide ] -
Precise determination of the dielectric constant and thickness of a nanolayer by use of surface plasmon resonance sensing and multiexperiment linear data analysis
Applied Optics, 45, 23, 6038-6044, 2006-08-10 -
A microfluidic system with integrated molecular imprinting polymer films for surface plasmon resonance detection
Journal of Micromechanics and Microengineering, 16, 7, 1251-1257, 2006-07-01 -
Optical waveguide biosensors constructed with subwavelength gratings
Applied Optics, 45, 9, 1938-1942, 2006-03-20 -
Direct determination of the refractive index and thickness of a biolayer based on coupled waveguide–surface plasmon resonance mode
, 31, 2, 187-189, 2006-01-15 -
Angular-interrogation attenuated total reflection metrology system for plasmonic sensors
Applied Optics, 44, 29, 6155-6162, 2005-10-10 -
An investigation into the influence of secondary structures on DNA hybridization using surface plasmon resonance biosensing
Chemical Physics Letters, 397, 4-6, 429-434, 2004-10-21 -
A sensitivity comparison of optical biosensors based on four different surface plasmon resonance modes
Biosensors and Bioelectronics, 20, 3, 633-642, 2004-10-15
[ Biomolecular interaction analysis,Conventional surface plasmon resonance,Coupled plasmon-waveguide resonance,Long-range surface plasmon resonance,Waveguide-coupled surface plasmon resonance ] -
Enhancement of the resolution of surface plasmon resonance biosensors by control of the size and distribution of nanoparticles
, 29, 12, 1390-1392, 2004-06-15
研討會著作
-
Detecting the hybridization of circulating tumor DNA by nitride surface-enhanced Raman spectroscopy
2023-01-01
-
DNA detection by SERS on InGaN quantum wells decorated with Al nanoparticles
2022-01-01
-
DNA detection by SERS on InGaN quantum wells decorated with Al nanoparticles
2022-01-01
-
Simulation approach to optimize fluorescence imaging performance of wide-field temporal-focusing microscopy with tunable wavelength excitation
2019-01-01
-
Simulation approach to optimize fluorescence imaging performance of wide-field temporal-focusing microscopy with tunable wavelength excitation
2019-01-01
-
Development of lipid targeted Raman probes for caenorhabditis elegans
2009-01-01
-
Super-resolution localization microscopy by quantum dot blinking
2009-01-01
-
Surface plasmon resonance biosensors with subwavelength grating waveguide
2007-04-30
[ Localized surface plasmons , Subwavelength grating , Surface plasmon resonance , Waveguide mode ] -
Plasmon-enhanced optical waveguide biosensors constructed with sub-wavelength gold grating
2006-11-30
[ Diffraction gratin , Optical biosensor , Sub-wavelength , Surface plasmon resonance , Waveguide ] -
Coupled waveguide-surface plasmon resonance biosensors constructed with sub-wavelength grating
2006-06-26
[ Localized surface plasmons , Sub-wavelength grating , Surface plasmon resonance , Waveguide mode ] -
A theoretical and experimental investigation into the enhancement of near electro-magnetic field via plasmonic effects
2006-06-26
[ Finite-difference time-domain , Near field scanning optical microscope , Particle plasmons , Plasmonic biosensing , Surface plasmons ] -
An investigation into the influence of secondary structures for DNA hybridization using surface plasmon resonance and surface-enhanced Raman scattering
2006-06-26
[ DNA secondary structural effect , Nanoparticles , Structural change , Surface plasmon resonance , Surface-enhanced Raman scattering ] -
A label-free optical waveguide biosensor with sob-wavelength gratings
2005-12-01
-
A microfluidic chip integrated with molecular imprinting polymers for surface plasmon resonance detection
1776-1779, 2005-11-09
[ Microfluidic , Micropumps , MIP , SPR ] -
Direct detection of the interaction of tiny analytes with receptors using an advanced plasmonic biosensor
107-117, 2005-08-16
[ Biomolecular interaction analysis , Direct detection , Plasmonic biosensors , Tiny analytes ] -
Microfluidic systems using localized molecular imprinting polymers for detection of nano-scale bio-molecules based on surface plasmon resonance
841-844, 2005-01-01
[ Microfluidics , Micropumps , MIP , SPR ] -
Optical biosensors based on four different surface plasmon resonance modes: Sensitivity comparison
148-159, 2004-11-16
[ Biomolecular interaction analysis , Conventional surface plasmon resonance , Coupled plasmon-waveguide resonance , Long-range surface plasmon resonance , Waveguide-coupled surface plasmon resonance ] -
Nanoparticle-enhanced ultrahigh-resolution surface plasmon resonance biosensors
140-147, 2004-11-16
[ Au nanoclusters , Optical biosensor , Surface Plasmon Resonance , Surface-enhanced Raman scattering ] -
Surface plasmon resonance phase-shift interferometry: Real-time microarray biomolecular interaction analysis
18-25, 2003-12-05
[ Biomolecular interaction analysis , DNA hybridization , Microarray , Phase-shifting interferometry , SPR imaging system ] -
Multi-experiment linear data analysis for ATR biosensors
175-184, 2002-12-31
[ Attenuated total reflection , Bio-molecular interaction analysis , Biosensor , Multi-experiment data analysis , Surface plasmon resonance ]
校內獲獎
- 115 研究傑出獎
- 114 研究傑出獎
- 113 優良論文貢獻獎
- 112 研究傑出獎
- 112 優良論文貢獻獎
- 110 研究傑出獎
- 109 研究傑出獎
- 102 新進教師補助
- 一種光譜解析造影法 [中華民國]
- 檢測基板及其製作方法、檢測裝置 [中華民國]
- METHOD OF FORMING ENHANCED SUPER-RESOLUTION IMAGE [美國]
- SENSING SUBSTRATE, MANUFACTURING METHOD THEREOF, AND SENSOR [美國]
- 形成增強之超解析影像的方法 [中華民國]
- Temporal Focusing-based Multiphoton Excitation Fluorescence Microcopy System Capable of Tunable-wavelength Excitation and Excitation Wacelegth Selection Module Thereof [美國]
- 激發波段可調式之時域聚焦多光子激發螢光顯微鏡系統及其激發光選擇模組 [中華民國]
- 粒子三維定位與追蹤裝置及其方法 [中華民國]
- 一種高靈敏度表面電漿共振感測器 SURFACE PLASMON RESONANCE SENSOR WITH HIGH SENSITIVITY [中華民國]
國立中央大學