國立中央大學教師履歷平台

教師個人簡歷 »

中文姓名

粘仲毅

英文姓名

Nien, Chung-Yi

電子郵件

joey.nien@g.ncu.edu.tw

Zelda 分子生物學 NGS數據分析基因組學發育遺傳 Maternal-to-Zygotic transition embryogenesis gene network gene regulation enhancer nucleosome occupancy 母代合子過渡 zygotic genome activation 合子基因體啟動表觀遺傳胚胎發育核小體佔據基因調控 Biology 生物科學

現職	國立中央大學生醫理工學院生命科學系副教授
專長	基因組學（NGS數據分析）分子生物學發育遺傳
專長簡述	基因組學（NGS數據分析),分子生物學,發育遺傳
最高學歷	美國New York University 生物學類博士
相關連結	個人網頁 GRB資訊系統

科技部學門領域	B - 生命科學 B20 - 生物學 B20A0 - 生物科學 B20A002 - 生物化學及分子生物
政府GRB研究專長領域	1 - 理 15 - 生物科學 1504 - 生物化學 9 - 管理、科學教育及行政 92 - 科學教育
教育部學門領域	4 - 科學 42 - 生命科學學門 4201 - 生物學類

其他補助

應用AI翻轉教室強化生物化學實驗課程成效的行動方案
1130801~1140731
[AI翻轉教室 , Applying AI to Flip the Classroom]

高教深耕計畫

113年度教學實踐研究推動與分析計畫-粘仲毅老師
1130101~1131231
以教育大數據為基之精準教育(5)
1120601~1121231

國科會計畫統計

利用STARR-SEQ與體學統合分析高通量鑒定果蠅早期胚胎發育強化子之功能與活性
1100801~1110731
[胚胎發育,表觀遺傳,合子基因體啟動,基因調控,母代合子過渡,核小體佔據,基因網,調控組 , embryogenesis,zygotic genome activation,gene regulation,maternal-to-zygotic transition,nucleosome occupancy,Zelda,enhancer,regulatory genome,gene network]
利用STARR-SEQ與體學統合分析高通量鑒定果蠅早期胚胎發育強化子之功能與活性
1090801~1100731
[胚胎發育,表觀遺傳,合子基因體啟動,基因調控,母代合子過渡,核小體佔據,基因網,調控組 , embryogenesis,zygotic genome activation,gene regulation,maternal-to-zygotic transition,nucleosome occupancy,Zelda,enhancer,regulatory genome,gene network]
利用體學研究方法分析果蠅之調控組
1080801~1090731
[調控組果蠅胚胎發育 , regulatome, transcriptome, Maternal-to-Zygotic transition, Zelda, STARR-Seq, enhancer, embryogenesis]
果蠅合子基因組啟動與胚胎多潛能分子機制之探討
1070801~1080731
[胚胎發育,表觀遺傳,合子基因體啟動,基因調控,母代合子過渡,核小體佔據,胚胎多能分化性, , embryogenesis, zygotic genome activation, gene regulation, epigenetic, maternal-to-zygotic transition, nucleosome occupancy, embryonic pluripotency, Zelda, ehancer]

期刊著作

Multi-level regulation of even-skipped stripes by the ubiquitous factor Zelda
Development (Cambridge), 150, 23, 2023-12-01
[ Drosophila,Cis regulation,Cross-repression,Embryogenesis,Even-skipped,Transcriptional regulation,Zelda ]
MicroRNA-152-3p and MicroRNA-196a-5p Are Downregulated When Müller Cells Are Promoted by Components of the Internal Limiting Membrane: Implications for Macular Hole Healing
International Journal of Molecular Sciences, 24, 24, 2023-12-01
[ internal limiting membrane,macular hole,microRNA,miR-152-3p,miR-196a-5p,Müller cells ]
Delivery and Transcriptome Assessment of an In Vitro Three-Dimensional Proximal Tubule Model Established by Human Kidney 2 Cells in Clinical Gelatin Sponges
International Journal of Molecular Sciences, 24, 21, 2023-11-01
[ comparative transcriptome analysis,gelatin spongy scaffold,HK-2 cells,nephrotoxicity,proximal tubule cells,three-dimensional culture,two-dimensional culture ]
Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis
Cell Death and Disease, 13, 12, 2022-12-01
Calcitriol and enamel matrix derivative differentially regulated cemento-induction and mineralization in human periodontal ligament-derived cells
Journal of Periodontology, 93, 10, 1553-1565, 2022-10-01
[ cementum,gene expression,periodontal regeneration ]
Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells
Chemico-Biological Interactions, 365, 2022-09-25
[ Apoptosis,DDR,Homologous recombination repair,ROS,Selenocysteine ]
Recurrence Rate of Proximal Contact Loss Between Implant Restorations and Adjacent Teeth After Proximal Contact Repair: A Retrospective Study
International Journal of Oral and Maxillofacial Implants, 37, 3, 579-585, 2022-01-01
[ Implant complication,Implant prosthesis,Proximal contact loss,Recurrence rate,Risk factors ]
Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice
Food and Chemical Toxicology, 156, 2021-10-01
[ Glucose intolerance,Hepatic steatosis,Insulin resistance,Macrophage infiltration,Obesity,Steatohepatitis ]
Application Of Dental Stem Cells In Three-Dimensional Tissue Regeneration
World Journal of Stem Cells, 13, 11, 1610-1624, 2021-01-01
[ Dental,Dental pulp stem cells,Dental stem cells,Periodontal ligament stem cells,Stem cells from apical papilla,Stem cells from human exfoliated deciduous teeth ]
Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo
Food and Chemical Toxicology, 142, 2020-08-01
[ Energy metabolism , Fat cells , Fatty acid oxidation , Mitochondria , Peroxisomes , Plasticizer ]
4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8
Toxicology, 440, 2020-07-01
The prevalence and associated factors of proximal contact loss between implant restoration and adjacent tooth after function: A retrospective study
Clinical Implant Dentistry and Related Research, 22, 3, 351-358, 2020-06-01
Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation
Genome Research, 25, 11, 1703-1714, 2015-11-01
Zelda potentiates morphogen activity by increasing chromatin accessibility
Current Biology, 24, 12, 1341-1346, 2014-06-16
Co-activation of microRNAs by Zelda is essential for early drosophila development
Development (Cambridge), 141, 10, 2108-2118, 2014-01-01
[ Co-activation , Gene network , MicroRNA , MZT , Zelda ]
Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in drosophila melanogaster
G3: Genes, Genomes, Genetics, 2, 8, 873-882, 2012-08-01
[ Array capture , Enrichment , Transcript isoforms , Transcriptome ]
Temporal coordination of gene networks by Zelda in the early Drosophila embryo
PLoS Genetics, 7, 10, 2011-10-01
The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
Nature, 456, 7220, 400-403, 2008-11-20
Increase of lipid peroxidation by cisplatin in WI38 cells but not in SV40-transformed WI38 cells
Journal of Biochemical and Molecular Toxicology, 17, 1, 39-46, 2003-04-16
[ 4-Hydroxy-2-nonenal,Cisplatin,F2-isoprostanes,Lipid peroxidation,Mitochondrial gene expression,Transformed cells ]

研討會著作

Blockage of Nrf2 and Autophagy by L-selenocystine Induces Selective Death in Nrf2-addicted Colorectal Cancer Cells through p62-Keap-1-Nrf2 Axis
2023-07-17
[ Colorectal Cancer,Autophagy,Nrf2 addiction,ROS,SeC ]

其他補助

應用AI翻轉教室強化生物化學實驗課程成效的行動方案 1130801~1140731 [AI翻轉教室 , Applying AI to Flip the Classroom]

高教深耕計畫

113年度教學實踐研究推動與分析計畫-粘仲毅老師 1130101~1131231

以教育大數據為基之精準教育(5) 1120601~1121231

國科會計畫統計

利用體學研究方法分析果蠅之調控組 1080801~1090731 [調控組 果蠅胚胎發育 , regulatome, transcriptome, Maternal-to-Zygotic transition, Zelda, STARR-Seq, enhancer, embryogenesis]

期刊著作

Multi-level regulation of even-skipped stripes by the ubiquitous factor Zelda Development (Cambridge), 150, 23, 2023-12-01 [ Drosophila,Cis regulation,Cross-repression,Embryogenesis,Even-skipped,Transcriptional regulation,Zelda ]

Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis Cell Death and Disease, 13, 12, 2022-12-01

Calcitriol and enamel matrix derivative differentially regulated cemento-induction and mineralization in human periodontal ligament-derived cells Journal of Periodontology, 93, 10, 1553-1565, 2022-10-01 [ cementum,gene expression,periodontal regeneration ]

Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells Chemico-Biological Interactions, 365, 2022-09-25 [ Apoptosis,DDR,Homologous recombination repair,ROS,Selenocysteine ]

Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice Food and Chemical Toxicology, 156, 2021-10-01 [ Glucose intolerance,Hepatic steatosis,Insulin resistance,Macrophage infiltration,Obesity,Steatohepatitis ]

Application Of Dental Stem Cells In Three-Dimensional Tissue Regeneration World Journal of Stem Cells, 13, 11, 1610-1624, 2021-01-01 [ Dental,Dental pulp stem cells,Dental stem cells,Periodontal ligament stem cells,Stem cells from apical papilla,Stem cells from human exfoliated deciduous teeth ]

Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo Food and Chemical Toxicology, 142, 2020-08-01 [ Energy metabolism , Fat cells , Fatty acid oxidation , Mitochondria , Peroxisomes , Plasticizer ]

4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8 Toxicology, 440, 2020-07-01

The prevalence and associated factors of proximal contact loss between implant restoration and adjacent tooth after function: A retrospective study Clinical Implant Dentistry and Related Research, 22, 3, 351-358, 2020-06-01

Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation Genome Research, 25, 11, 1703-1714, 2015-11-01

Zelda potentiates morphogen activity by increasing chromatin accessibility Current Biology, 24, 12, 1341-1346, 2014-06-16

Co-activation of microRNAs by Zelda is essential for early drosophila development Development (Cambridge), 141, 10, 2108-2118, 2014-01-01 [ Co-activation , Gene network , MicroRNA , MZT , Zelda ]

Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in drosophila melanogaster G3: Genes, Genomes, Genetics, 2, 8, 873-882, 2012-08-01 [ Array capture , Enrichment , Transcript isoforms , Transcriptome ]

Temporal coordination of gene networks by Zelda in the early Drosophila embryo PLoS Genetics, 7, 10, 2011-10-01

The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila Nature, 456, 7220, 400-403, 2008-11-20

Increase of lipid peroxidation by cisplatin in WI38 cells but not in SV40-transformed WI38 cells Journal of Biochemical and Molecular Toxicology, 17, 1, 39-46, 2003-04-16 [ 4-Hydroxy-2-nonenal,Cisplatin,F2-isoprostanes,Lipid peroxidation,Mitochondrial gene expression,Transformed cells ]

研討會著作

Blockage of Nrf2 and Autophagy by L-selenocystine Induces Selective Death in Nrf2-addicted Colorectal Cancer Cells through p62-Keap-1-Nrf2 Axis 2023-07-17 [ Colorectal Cancer,Autophagy,Nrf2 addiction,ROS,SeC ]

應用AI翻轉教室強化生物化學實驗課程成效的行動方案
1130801~1140731
[AI翻轉教室 , Applying AI to Flip the Classroom]

113年度教學實踐研究推動與分析計畫-粘仲毅老師
1130101~1131231

以教育大數據為基之精準教育(5)
1120601~1121231

利用體學研究方法分析果蠅之調控組
1080801~1090731
[調控組果蠅胚胎發育 , regulatome, transcriptome, Maternal-to-Zygotic transition, Zelda, STARR-Seq, enhancer, embryogenesis]

Multi-level regulation of even-skipped stripes by the ubiquitous factor Zelda
Development (Cambridge), 150, 23, 2023-12-01
[ Drosophila,Cis regulation,Cross-repression,Embryogenesis,Even-skipped,Transcriptional regulation,Zelda ]

Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis
Cell Death and Disease, 13, 12, 2022-12-01

Calcitriol and enamel matrix derivative differentially regulated cemento-induction and mineralization in human periodontal ligament-derived cells
Journal of Periodontology, 93, 10, 1553-1565, 2022-10-01
[ cementum,gene expression,periodontal regeneration ]

Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells
Chemico-Biological Interactions, 365, 2022-09-25
[ Apoptosis,DDR,Homologous recombination repair,ROS,Selenocysteine ]

Di(2-ethylhexyl)phthalate exposure exacerbates metabolic disorders in diet-induced obese mice
Food and Chemical Toxicology, 156, 2021-10-01
[ Glucose intolerance,Hepatic steatosis,Insulin resistance,Macrophage infiltration,Obesity,Steatohepatitis ]

Application Of Dental Stem Cells In Three-Dimensional Tissue Regeneration
World Journal of Stem Cells, 13, 11, 1610-1624, 2021-01-01
[ Dental,Dental pulp stem cells,Dental stem cells,Periodontal ligament stem cells,Stem cells from apical papilla,Stem cells from human exfoliated deciduous teeth ]

Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo
Food and Chemical Toxicology, 142, 2020-08-01
[ Energy metabolism , Fat cells , Fatty acid oxidation , Mitochondria , Peroxisomes , Plasticizer ]

4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8
Toxicology, 440, 2020-07-01

The prevalence and associated factors of proximal contact loss between implant restoration and adjacent tooth after function: A retrospective study
Clinical Implant Dentistry and Related Research, 22, 3, 351-358, 2020-06-01

Zelda overcomes the high intrinsic nucleosome barrier at enhancers during Drosophila zygotic genome activation
Genome Research, 25, 11, 1703-1714, 2015-11-01

Zelda potentiates morphogen activity by increasing chromatin accessibility
Current Biology, 24, 12, 1341-1346, 2014-06-16

Co-activation of microRNAs by Zelda is essential for early drosophila development
Development (Cambridge), 141, 10, 2108-2118, 2014-01-01
[ Co-activation , Gene network , MicroRNA , MZT , Zelda ]

Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in drosophila melanogaster
G3: Genes, Genomes, Genetics, 2, 8, 873-882, 2012-08-01
[ Array capture , Enrichment , Transcript isoforms , Transcriptome ]

Temporal coordination of gene networks by Zelda in the early Drosophila embryo
PLoS Genetics, 7, 10, 2011-10-01

The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila
Nature, 456, 7220, 400-403, 2008-11-20

Increase of lipid peroxidation by cisplatin in WI38 cells but not in SV40-transformed WI38 cells
Journal of Biochemical and Molecular Toxicology, 17, 1, 39-46, 2003-04-16
[ 4-Hydroxy-2-nonenal,Cisplatin,F2-isoprostanes,Lipid peroxidation,Mitochondrial gene expression,Transformed cells ]

Blockage of Nrf2 and Autophagy by L-selenocystine Induces Selective Death in Nrf2-addicted Colorectal Cancer Cells through p62-Keap-1-Nrf2 Axis
2023-07-17
[ Colorectal Cancer,Autophagy,Nrf2 addiction,ROS,SeC ]