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中文姓名

陳盛良

英文姓名

Chen, Shen-Liang

電子郵件

slchen@cc.ncu.edu.tw

PGC-1α Bhlhe40 myogenesis muscle MyoD Skeletal muscle 骨骼肌過氧化氫體 peroxisome 內分泌分子生物學基因表達基因調控 transcription 肌肉 MEHP Myokine DEHP Gene expression Electrical stimulation Biology Bioreactor Myogenic differentiation Metastasis Cyclic stretching Polydimethylsiloxane Polypyrrole 肌肉生成 TRPV1 oxidative metabolism Breast cancer FGF21 IL-6 Irisin

現職	國立中央大學生醫理工學院生命科學系教授
專長	基因調控基因表達內分泌分子生物學
專長簡述	基因調控,基因表達,內分泌,分子生物學
最高學歷	澳洲The University of Queensland 生物化學研究所博士
相關連結	個人網頁 Research Gate GRB資訊系統

科技部學門領域	B - 生命科學 B10 - 醫學 B1010 - 基礎醫學自由型計畫 B101004 - 醫學之生化及分子生物 B101018 - 幹細胞/再生生物醫學 B10A0 - 形態及生理醫學 B10A002 - 細胞生物及解剖 B10B0 - 生化及藥理醫學 B10B002 - 醫學生化及分子生物 B20 - 生物學 B2010 - 基礎生物學自由型計畫 B2010C0 - 生物學之生化及分子生物 B20A0 - 生物科學 B20A001 - 基礎生物 B20A002 - 生物化學及分子生物 E - 工程及應用科學 E15 - 光電工程 E1506 - 生醫光電
政府GRB研究專長領域	1 - 理 15 - 生物科學 17 - 生物技術(理) 4 - 醫 40 - 基礎醫學 4L - 生物技術(醫)
教育部學門領域	4 - 科學 42 - 生命科學學門 4201 - 生物學類

高教深耕計畫

肌肉運動激素與乳癌患者預後的相關性
1130801~1131231
[骨骼肌,乳癌,肌肉運動激素 , Skeletal muscle,Breast cancer,Myokine,IL-6,Irisin,Fgf21]
肌肉激素Irisin and Fgf21在肌肉發育與運動中的交互作用
1120101~1121231
[肌肉,幹細胞,肌肉激素,運動,肌肉生成 , muscle,stem cell,myokine,exercise,myogenesis]
探討新穎生物反應器誘發肌肉生成細胞增生及分化之機制
1100101~1101231
探討新穎生物反應器誘發肌肉生成細胞增生及分化之機制
1100101~1101231

國科會計畫統計

探討塑化劑在癌症誘導的惡病質症中影響骨骼肌萎縮的機制
1110801~1120731
[骨骼肌,肌肉萎縮,塑化劑,癌症,惡病質症 , muscle,MyoD,DEHP,MEHP,cancer,cachexia]
肌肉生成轉錄因子MRFs基因之表現及功能在正常及病態生理中的調控
1100801~1110731
[骨骼肌 , MyoD]
探討Bhlhe40對粒線體和過氧化氫體在肌肉生成過程中的交互作用之調控機制
1080801~1090731
[骨骼肌,粒線體,過氧化氫體,PGC-1α,Bhlhe40 , skeletal muscle, mitochondria, peroxisomes, PGC-1α, Bhlhe40]
Bhlhe40轉錄因子在肌肉細胞中調控過氧化氫體功能及數量的分子機制
1070801~1080731
[骨骼肌,Bhlhe40,PGC-1α,活性氧化物質,過氧化氫體,肌肉生成 , skeletal muscle, Bhlhe40, PGC-1α, ROS, peroxisome, myogenesis]
塑化劑鄰苯二甲酸二辛酯在代謝性疾病致病過程中之角色及其分子機轉－探討塑化劑藉由TRPV1 和PGC-1α影響骨骼肌細胞代謝及分化能力的機制(3/3)
1070801~1080731
探討過氧化氫體在骨骼肌發育及再生過程中的功能及調控機制
1060801~1070731
[ skeletal muscle, Bhlhe40, PGC-1α, oxidative metabolism, peroxisome, myogenesis,]
塑化劑鄰苯二甲酸二辛酯在代謝性疾病致病過程中之角色及其分子機轉－探討塑化劑藉由TRPV1 和PGC-1α影響骨骼肌細胞代謝及分化能力的機制(2/3)
1060801~1070731
探討Bhlhe40轉錄因子在過氧化氫體(peroxisome)生物學與有氧代謝的調控角色
1050801~1060731
[PGC-1α,Bhlhe40,肌肉,過氧化氫體,轉錄,有氧代謝 , PGC-1α, Bhlhe40, muscle, peroxisome, oxidative metabolism, transcription]
塑化劑鄰苯二甲酸二辛酯在代謝性疾病致病過程中之角色及其分子機轉－探討塑化劑藉由TRPV1 和PGC-1α影響骨骼肌細胞代謝及分化能力的機制(1/3)
1050801~1060731
[DEHP, MEHP, TRPV1, PGC-1, 肌肉, 過氧化氫體, , DEHP, MEHP, TRPV1, PGC-1α, muscle, peroxisome,]
探討Bhlhe40轉錄因子對肌肉細胞代謝以及代謝基因的調控機制
1040801~1050731
[PGC-1α, Bhlhe40, muscle, promoter, transcription, metabolism ]

產學合作計畫統計

113年中大聯新醫院聯合研發中心計畫-肌肉運動激素與乳癌患者預後的相關性
1130801~1140731
[骨骼肌,乳癌,肌肉運動激素 , Skeletal muscle,Myokine,Breast cancer,IL-6,Irisin,FGF21]

期刊著作

MyoD Over-Expression Rescues GST-bFGF Repressed Myogenesis
International Journal of Molecular Sciences, 25, 8, 2024-04-01
[ bFGF,cell cycle,differentiation,muscle,MyoD,myogenesis ]
Development of a multifunctional bioreactor to evaluate the promotion effects of cyclic stretching and electrical stimulation on muscle differentiation
Bioengineering and Translational Medicine, 9, 2, 2024-03-01
[ bioreactor,cyclic stretching,electrical stimulation,myoblasts,myogenic differentiation,polydimethylsiloxane,polypyrrole ]
Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis
Journal of Muscle Research and Cell Motility, 45, 1, 21-39, 2024-03-01
[ microRNA,mRNA stability,Muscle,MyoD,Myogenesis ]
The proliferation and differentiation of skeletal muscle stem cells are enhanced in a bioreactor
Biotechnology and Bioengineering, 2024-01-01
[ bioreactor,differentiation,muscle,myogenesis,proliferation,stem cell ]
Deposition of polypyrrole on wrinkled polydimethylsiloxane to fabricate stretchable conductive membranes for multifunctional bioreactor applications
Progress in Organic Coatings, 181, 2023-08-01
[ Bioreactor,Cyclic stretching,Electrical stimulation,Myogenic differentiation,Polydimethylsiloxane,Polypyrrole ]
Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors Is Critical for Myogenesis
International Journal of Molecular Sciences, 24, 15, 2023-08-01
[ catalase,mitochondria,muscle,myogenesis,peroxisome,Pex3 ]
The cooperation of cis-elements during M-cadherin promoter activation
Biochemical Journal, 478, 4, 911-926, 2021-02-01
Di-(2-ethylhexyl) phthalate limits the pleiotropic effects of statins in chronic kidney disease patients undergoing dialysis and endothelial cells
Environmental Pollution, 267, 2020-12-01
Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo
Food and Chemical Toxicology, 142, 2020-08-01
[ Energy metabolism , Fat cells , Fatty acid oxidation , Mitochondria , Peroxisomes , Plasticizer ]
MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells
Bioscience Reports, 40, 4, 2020-04-01
Mutagenesis of the dengue virus NS4A protein reveals a novel cytosolic N-terminal domain responsible for virus-induced cytopathic effects and intramolecular interactions within the N-terminus of NS4A
Journal of General Virology, 100, 3, 457-470, 2019-03-01
[ Cytopathic effect , Dengue virus , Intramolecular interaction , NS4A , RNA replication , Scanning mutagenesis ]
Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells
Redox Biology, 20, 321-333, 2019-01-01
[ Bhlhe40 , Oxidative metabolism , Peroxisome , PGC-1α , Skeletal muscle ]
Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover
Oncogene, 36, 37, 5274-5284, 2017-09-14
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy
Autophagy, 12, 12, 2271-2285, 2016-12-01
[ DAPK2 , HCC , selective autophagy , SQSTM1/p62 , THR ]
Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway
Cell Death and Disease, 7, 8, 2016-08-04
Transduction of recombinant M3-p53-R12 protein enhances human leukemia cell apoptosis
, 7, 10, 1360-1373, 2016-01-01
[ And protein drug , Apoptosis , Cancer , Leukemia , MyoD , P53 ]
Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer
Bioscience Reports, 35, 2015-02-05
[ Muscle , MyoD , Myogenesis , Pax7 , Wnt3a , β-catenin ]
Bhlhe40 represses PGC-1α activity on metabolic gene promoters in myogenic cells
Molecular and Cellular Biology, 35, 14, 2518-2529, 2015-01-01
Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment
, 35, 3, 287-294, 2015-01-01
[ Caffeine , Calcium , Embryogenesis , Myogenesis , Zebrafish ]
Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors
Molecular and Cellular Endocrinology, 383, 1-2, 147-158, 2014-03-05
[ Akt , IPSC , Muscle , Nuclear receptor , Oct4 , VPA ]
Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts
PLoS ONE, 9, 2, 2014-02-13
Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation
Cell and Tissue Research, 358, 2, 551-566, 2014-01-01
[ Double homeobox gene , Duxbl , Muscle regeneration , Myogenesis , Satellite cells ]
FoxO6 and PGC-1α form a regulatory loop in myogenic cells
Bioscience Reports, 33, 3, 485-500, 2013-07-08
[ FoxO6 , Muscle , Oxidative metabolism , PGC-1α , Promoter , Transcription ]
FoxO6 and PGC-1α form a regulatory loop in myogenic cells.
Bioscience Reports, 33, 3, 2013-01-01
Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL
Cell Death and Differentiation, 19, 11, 1802-1814, 2012-11-01
[ apoptosis , metastasis , thyroid hormone receptor , TRAIL ]
Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis
EMBO Journal, 31, 7, 1739-1751, 2012-04-04
[ Epigenetics , miR-546 , Mybbp1a , MyoD , myogenesis ]
Using isothermal titration calorimetry to real-time monitor the heat of metabolism: A case study using PC12 cells and Aβ(1-40)
Colloids and Surfaces B: Biointerfaces, 83, 2, 307-312, 2011-04-01
[ β-Amyloid , Alzheimer's disease , Biothermodynamics , Isothermal titration calorimetry ]
Valproic acid enhances Oct4 promoter activity in myogenic cells
Journal of Cellular Biochemistry, 110, 4, 995-1004, 2010-07-01
[ Muscle , Oct4 , Pluripotency , RAR , Retinoic acid , VPA ]
Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements
Biochemical Journal, 428, 2, 223-233, 2010-06-01
[ M-cadherin , MyoD , Myogenesis , Myogenic regulatory factor (MRF) , N-cadherin ]
P/CAF rescues the Bhlhe40-mediated repression of MyoD transactivation
Biochemical Journal, 422, 2, 343-352, 2009-09-01
[ Basic helix-loop-helix family , Member e40 (Bhlhe40) , Muscle , Myogenic differentiation factor D (MyoD) , p300/CBP-associated factor (P/CAF) , Peroxisome-proliferator-activated receptor γ co-activator 1α (PGC-1α) ]
SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α(PGC-1α) gene in skeletal muscle through the PGC-1α autoregulatory loop and interaction with MyoD
Journal of Biological Chemistry, 284, 33, 21872-21880, 2009-08-14
Simultaneous overexpression of Oct4 and Nanog abrogates terminal myogenesis
American Journal of Physiology - Cell Physiology, 297, 1, 2009-07-01
[ Differentiation , Pax7 , Pluripotency , Stem cell ]
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines
Endocrinology, 149, 8, 3817-3831, 2008-08-01
Myogenic basic helix-loop-helix proteins regulate the expression of peroxisomal proliferator activated receptor-γ coactivator-1α
Endocrinology, 147, 6, 3093-3106, 2006-06-01
Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance
British Journal of Cancer, 91, 11, 1924-1930, 2004-11-29
[ Gastric cancer , Microarray , Real-time RT-PCR , SPARC ]
Regulation of fibronectin by thyroid hormone receptors
Journal of Molecular Endocrinology, 33, 2, 445-458, 2004-10-01
Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen and coagulation proteins
Endocrinology, 145, 6, 2804-2814, 2004-06-01
Plasma protein regulation by thyroid hormone
Journal of Endocrinology, 179, 3, 367-377, 2003-12-01
Mitogen-activated protein kinases potentiate thyroid hormone receptor transcriptional activity by stabilizing its protein
Endocrinology, 144, 4, 1407-1419, 2003-04-01
p53 is a regulator of the metastasis suppressor gene Nm23-H1
Molecular Carcinogenesis, 36, 4, 204-214, 2003-04-01
[ Metastasis , Nm23-H1 , p53 , Regulation , Suppressor gene ]
Characterization of the retinoid orphan-related receptor-α coactivator binding interface: A structural basis for ligand-independent transcription
Molecular Endocrinology, 16, 5, 998-1012, 2002-05-18
The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2
Journal of Biological Chemistry, 277, 6, 4324-4333, 2002-02-08
SOX18 directly interacts with MEF2C in endothelial cells
Biochemical and Biophysical Research Communications, 287, 2, 493-500, 2001-09-21
[ Endothelial , MEF2C , Protein-protein interaction , Ragged , Sox18 , Transcription , Vasculogenesis ]
Subcellular localization of the steroid receptor coactivators (SRCs) and MEF2 in muscle and rhabdomyosarcoma cells
Molecular Endocrinology, 15, 5, 783-796, 2001-05-17
Impaired interaction of mutant thyroid hormone receptors associated with human hepatocellular carcinoma with transcriptional coregulators
Endocrinology, 142, 2, 653-662, 2001-01-01
The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C- dependent gene expression and skeletal muscle differentiation
Genes and Development, 14, 10, 1209-1228, 2000-05-15
[ Gene expression , GRIP-1 , Myogenic cells , Skeletal muscle differentiation ]
Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells
Molecular Carcinogenesis, 26, 1, 53-61, 1999-09-15
[ Hepatocellular carcinoma , Mutation , Receptor , Thyroid hormone ]
The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with myoD
Molecular Endocrinology, 13, 7, 1155-1168, 1999-01-01
The gene regulating activity of thyroid hormone nuclear receptors is modulated by cell-type specific factors
Biochemical and Biophysical Research Communications, 238, 2, 280-284, 1997-09-18
Dominant negative activity of mutant thyroid hormone receptors from patients with hepatocellular carcinoma
Endocrinology, 138, 12, 5308-5315, 1997-01-01

高教深耕計畫

肌肉運動激素與乳癌患者預後的相關性 1130801~1131231 [骨骼肌,乳癌,肌肉運動激素 , Skeletal muscle,Breast cancer,Myokine,IL-6,Irisin,Fgf21]

肌肉激素Irisin and Fgf21在肌肉發育與運動中的交互作用 1120101~1121231 [肌肉,幹細胞,肌肉激素,運動,肌肉生成 , muscle,stem cell,myokine,exercise,myogenesis]

探討新穎生物反應器誘發肌肉生成細胞增生及分化之機制 1100101~1101231

探討新穎生物反應器誘發肌肉生成細胞增生及分化之機制 1100101~1101231

國科會計畫統計

探討塑化劑在癌症誘導的惡病質症中影響骨骼肌萎縮的機制 1110801~1120731 [骨骼肌,肌肉萎縮,塑化劑,癌症,惡病質症 , muscle,MyoD,DEHP,MEHP,cancer,cachexia]

肌肉生成轉錄因子MRFs基因之表現及功能在正常及病態生理中的調控 1100801~1110731 [骨骼肌 , MyoD]

探討Bhlhe40對粒線體和過氧化氫體在肌肉生成過程中的交互作用之調控機制 1080801~1090731 [骨骼肌,粒線體,過氧化氫體,PGC-1α,Bhlhe40 , skeletal muscle, mitochondria, peroxisomes, PGC-1α, Bhlhe40]

Bhlhe40轉錄因子在肌肉細胞中調控過氧化氫體功能及數量的分子機制 1070801~1080731 [骨骼肌,Bhlhe40,PGC-1α,活性氧化物質,過氧化氫體,肌肉生成 , skeletal muscle, Bhlhe40, PGC-1α, ROS, peroxisome, myogenesis]

塑化劑鄰苯二甲酸二辛酯在代謝性疾病致病過程中之角色及其分子機轉 －探討塑化劑藉由TRPV1 和PGC-1α影響骨骼肌細胞代謝及分化能力的機制(3/3) 1070801~1080731

探討過氧化氫體在骨骼肌發育及再生過程中的功能及調控機制 1060801~1070731 [ skeletal muscle, Bhlhe40, PGC-1α, oxidative metabolism, peroxisome, myogenesis,]

塑化劑鄰苯二甲酸二辛酯在代謝性疾病致病過程中之角色及其分子機轉 －探討塑化劑藉由TRPV1 和PGC-1α影響骨骼肌細胞代謝及分化能力的機制(2/3) 1060801~1070731

探討Bhlhe40轉錄因子在過氧化氫體(peroxisome)生物學與有氧代謝的調 控角色 1050801~1060731 [PGC-1α,Bhlhe40,肌肉,過氧化氫體,轉錄,有氧代謝 , PGC-1α, Bhlhe40, muscle, peroxisome, oxidative metabolism, transcription]

探討Bhlhe40轉錄因子對肌肉細胞代謝以及代謝基因的調控機制 1040801~1050731 [PGC-1α, Bhlhe40, muscle, promoter, transcription, metabolism ]

產學合作計畫統計

113年中大聯新醫院聯合研發中心計畫-肌肉運動激素與乳癌患者預後的相關性 1130801~1140731 [骨骼肌,乳癌,肌肉運動激素 , Skeletal muscle,Myokine,Breast cancer,IL-6,Irisin,FGF21]

期刊著作

MyoD Over-Expression Rescues GST-bFGF Repressed Myogenesis International Journal of Molecular Sciences, 25, 8, 2024-04-01 [ bFGF,cell cycle,differentiation,muscle,MyoD,myogenesis ]

Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis Journal of Muscle Research and Cell Motility, 45, 1, 21-39, 2024-03-01 [ microRNA,mRNA stability,Muscle,MyoD,Myogenesis ]

The proliferation and differentiation of skeletal muscle stem cells are enhanced in a bioreactor Biotechnology and Bioengineering, 2024-01-01 [ bioreactor,differentiation,muscle,myogenesis,proliferation,stem cell ]

Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors Is Critical for Myogenesis International Journal of Molecular Sciences, 24, 15, 2023-08-01 [ catalase,mitochondria,muscle,myogenesis,peroxisome,Pex3 ]

The cooperation of cis-elements during M-cadherin promoter activation Biochemical Journal, 478, 4, 911-926, 2021-02-01

Di-(2-ethylhexyl) phthalate limits the pleiotropic effects of statins in chronic kidney disease patients undergoing dialysis and endothelial cells Environmental Pollution, 267, 2020-12-01

Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo Food and Chemical Toxicology, 142, 2020-08-01 [ Energy metabolism , Fat cells , Fatty acid oxidation , Mitochondria , Peroxisomes , Plasticizer ]

MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells Bioscience Reports, 40, 4, 2020-04-01

Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells Redox Biology, 20, 321-333, 2019-01-01 [ Bhlhe40 , Oxidative metabolism , Peroxisome , PGC-1α , Skeletal muscle ]

Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover Oncogene, 36, 37, 5274-5284, 2017-09-14

Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy Autophagy, 12, 12, 2271-2285, 2016-12-01 [ DAPK2 , HCC , selective autophagy , SQSTM1/p62 , THR ]

Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway Cell Death and Disease, 7, 8, 2016-08-04

Transduction of recombinant M3-p53-R12 protein enhances human leukemia cell apoptosis , 7, 10, 1360-1373, 2016-01-01 [ And protein drug , Apoptosis , Cancer , Leukemia , MyoD , P53 ]

Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer Bioscience Reports, 35, 2015-02-05 [ Muscle , MyoD , Myogenesis , Pax7 , Wnt3a , β-catenin ]

Bhlhe40 represses PGC-1α activity on metabolic gene promoters in myogenic cells Molecular and Cellular Biology, 35, 14, 2518-2529, 2015-01-01

Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment , 35, 3, 287-294, 2015-01-01 [ Caffeine , Calcium , Embryogenesis , Myogenesis , Zebrafish ]

Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors Molecular and Cellular Endocrinology, 383, 1-2, 147-158, 2014-03-05 [ Akt , IPSC , Muscle , Nuclear receptor , Oct4 , VPA ]

Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts PLoS ONE, 9, 2, 2014-02-13

Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation Cell and Tissue Research, 358, 2, 551-566, 2014-01-01 [ Double homeobox gene , Duxbl , Muscle regeneration , Myogenesis , Satellite cells ]

FoxO6 and PGC-1α form a regulatory loop in myogenic cells Bioscience Reports, 33, 3, 485-500, 2013-07-08 [ FoxO6 , Muscle , Oxidative metabolism , PGC-1α , Promoter , Transcription ]

FoxO6 and PGC-1α form a regulatory loop in myogenic cells. Bioscience Reports, 33, 3, 2013-01-01

Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL Cell Death and Differentiation, 19, 11, 1802-1814, 2012-11-01 [ apoptosis , metastasis , thyroid hormone receptor , TRAIL ]

Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis EMBO Journal, 31, 7, 1739-1751, 2012-04-04 [ Epigenetics , miR-546 , Mybbp1a , MyoD , myogenesis ]

Using isothermal titration calorimetry to real-time monitor the heat of metabolism: A case study using PC12 cells and Aβ(1-40) Colloids and Surfaces B: Biointerfaces, 83, 2, 307-312, 2011-04-01 [ β-Amyloid , Alzheimer's disease , Biothermodynamics , Isothermal titration calorimetry ]

Valproic acid enhances Oct4 promoter activity in myogenic cells Journal of Cellular Biochemistry, 110, 4, 995-1004, 2010-07-01 [ Muscle , Oct4 , Pluripotency , RAR , Retinoic acid , VPA ]

Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements Biochemical Journal, 428, 2, 223-233, 2010-06-01 [ M-cadherin , MyoD , Myogenesis , Myogenic regulatory factor (MRF) , N-cadherin ]

SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α(PGC-1α) gene in skeletal muscle through the PGC-1α autoregulatory loop and interaction with MyoD Journal of Biological Chemistry, 284, 33, 21872-21880, 2009-08-14

Simultaneous overexpression of Oct4 and Nanog abrogates terminal myogenesis American Journal of Physiology - Cell Physiology, 297, 1, 2009-07-01 [ Differentiation , Pax7 , Pluripotency , Stem cell ]

Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines Endocrinology, 149, 8, 3817-3831, 2008-08-01

Myogenic basic helix-loop-helix proteins regulate the expression of peroxisomal proliferator activated receptor-γ coactivator-1α Endocrinology, 147, 6, 3093-3106, 2006-06-01

Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance British Journal of Cancer, 91, 11, 1924-1930, 2004-11-29 [ Gastric cancer , Microarray , Real-time RT-PCR , SPARC ]

Regulation of fibronectin by thyroid hormone receptors Journal of Molecular Endocrinology, 33, 2, 445-458, 2004-10-01

Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen and coagulation proteins Endocrinology, 145, 6, 2804-2814, 2004-06-01

Plasma protein regulation by thyroid hormone Journal of Endocrinology, 179, 3, 367-377, 2003-12-01

Mitogen-activated protein kinases potentiate thyroid hormone receptor transcriptional activity by stabilizing its protein Endocrinology, 144, 4, 1407-1419, 2003-04-01

p53 is a regulator of the metastasis suppressor gene Nm23-H1 Molecular Carcinogenesis, 36, 4, 204-214, 2003-04-01 [ Metastasis , Nm23-H1 , p53 , Regulation , Suppressor gene ]

Characterization of the retinoid orphan-related receptor-α coactivator binding interface: A structural basis for ligand-independent transcription Molecular Endocrinology, 16, 5, 998-1012, 2002-05-18

The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2 Journal of Biological Chemistry, 277, 6, 4324-4333, 2002-02-08

SOX18 directly interacts with MEF2C in endothelial cells Biochemical and Biophysical Research Communications, 287, 2, 493-500, 2001-09-21 [ Endothelial , MEF2C , Protein-protein interaction , Ragged , Sox18 , Transcription , Vasculogenesis ]

Subcellular localization of the steroid receptor coactivators (SRCs) and MEF2 in muscle and rhabdomyosarcoma cells Molecular Endocrinology, 15, 5, 783-796, 2001-05-17

Impaired interaction of mutant thyroid hormone receptors associated with human hepatocellular carcinoma with transcriptional coregulators Endocrinology, 142, 2, 653-662, 2001-01-01

The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C- dependent gene expression and skeletal muscle differentiation Genes and Development, 14, 10, 1209-1228, 2000-05-15 [ Gene expression , GRIP-1 , Myogenic cells , Skeletal muscle differentiation ]

Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells Molecular Carcinogenesis, 26, 1, 53-61, 1999-09-15 [ Hepatocellular carcinoma , Mutation , Receptor , Thyroid hormone ]

The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with myoD Molecular Endocrinology, 13, 7, 1155-1168, 1999-01-01

The gene regulating activity of thyroid hormone nuclear receptors is modulated by cell-type specific factors Biochemical and Biophysical Research Communications, 238, 2, 280-284, 1997-09-18

Dominant negative activity of mutant thyroid hormone receptors from patients with hepatocellular carcinoma Endocrinology, 138, 12, 5308-5315, 1997-01-01

肌肉運動激素與乳癌患者預後的相關性
1130801~1131231
[骨骼肌,乳癌,肌肉運動激素 , Skeletal muscle,Breast cancer,Myokine,IL-6,Irisin,Fgf21]

肌肉激素Irisin and Fgf21在肌肉發育與運動中的交互作用
1120101~1121231
[肌肉,幹細胞,肌肉激素,運動,肌肉生成 , muscle,stem cell,myokine,exercise,myogenesis]

探討新穎生物反應器誘發肌肉生成細胞增生及分化之機制
1100101~1101231

探討新穎生物反應器誘發肌肉生成細胞增生及分化之機制
1100101~1101231

探討塑化劑在癌症誘導的惡病質症中影響骨骼肌萎縮的機制
1110801~1120731
[骨骼肌,肌肉萎縮,塑化劑,癌症,惡病質症 , muscle,MyoD,DEHP,MEHP,cancer,cachexia]

肌肉生成轉錄因子MRFs基因之表現及功能在正常及病態生理中的調控
1100801~1110731
[骨骼肌 , MyoD]

探討Bhlhe40對粒線體和過氧化氫體在肌肉生成過程中的交互作用之調控機制
1080801~1090731
[骨骼肌,粒線體,過氧化氫體,PGC-1α,Bhlhe40 , skeletal muscle, mitochondria, peroxisomes, PGC-1α, Bhlhe40]

Bhlhe40轉錄因子在肌肉細胞中調控過氧化氫體功能及數量的分子機制
1070801~1080731
[骨骼肌,Bhlhe40,PGC-1α,活性氧化物質,過氧化氫體,肌肉生成 , skeletal muscle, Bhlhe40, PGC-1α, ROS, peroxisome, myogenesis]

塑化劑鄰苯二甲酸二辛酯在代謝性疾病致病過程中之角色及其分子機轉－探討塑化劑藉由TRPV1 和PGC-1α影響骨骼肌細胞代謝及分化能力的機制(3/3)
1070801~1080731

探討過氧化氫體在骨骼肌發育及再生過程中的功能及調控機制
1060801~1070731
[ skeletal muscle, Bhlhe40, PGC-1α, oxidative metabolism, peroxisome, myogenesis,]

塑化劑鄰苯二甲酸二辛酯在代謝性疾病致病過程中之角色及其分子機轉－探討塑化劑藉由TRPV1 和PGC-1α影響骨骼肌細胞代謝及分化能力的機制(2/3)
1060801~1070731

探討Bhlhe40轉錄因子在過氧化氫體(peroxisome)生物學與有氧代謝的調控角色
1050801~1060731
[PGC-1α,Bhlhe40,肌肉,過氧化氫體,轉錄,有氧代謝 , PGC-1α, Bhlhe40, muscle, peroxisome, oxidative metabolism, transcription]

探討Bhlhe40轉錄因子對肌肉細胞代謝以及代謝基因的調控機制
1040801~1050731
[PGC-1α, Bhlhe40, muscle, promoter, transcription, metabolism ]

113年中大聯新醫院聯合研發中心計畫-肌肉運動激素與乳癌患者預後的相關性
1130801~1140731
[骨骼肌,乳癌,肌肉運動激素 , Skeletal muscle,Myokine,Breast cancer,IL-6,Irisin,FGF21]

MyoD Over-Expression Rescues GST-bFGF Repressed Myogenesis
International Journal of Molecular Sciences, 25, 8, 2024-04-01
[ bFGF,cell cycle,differentiation,muscle,MyoD,myogenesis ]

Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis
Journal of Muscle Research and Cell Motility, 45, 1, 21-39, 2024-03-01
[ microRNA,mRNA stability,Muscle,MyoD,Myogenesis ]

The proliferation and differentiation of skeletal muscle stem cells are enhanced in a bioreactor
Biotechnology and Bioengineering, 2024-01-01
[ bioreactor,differentiation,muscle,myogenesis,proliferation,stem cell ]

Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors Is Critical for Myogenesis
International Journal of Molecular Sciences, 24, 15, 2023-08-01
[ catalase,mitochondria,muscle,myogenesis,peroxisome,Pex3 ]

The cooperation of cis-elements during M-cadherin promoter activation
Biochemical Journal, 478, 4, 911-926, 2021-02-01

Di-(2-ethylhexyl) phthalate limits the pleiotropic effects of statins in chronic kidney disease patients undergoing dialysis and endothelial cells
Environmental Pollution, 267, 2020-12-01

Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo
Food and Chemical Toxicology, 142, 2020-08-01
[ Energy metabolism , Fat cells , Fatty acid oxidation , Mitochondria , Peroxisomes , Plasticizer ]

MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells
Bioscience Reports, 40, 4, 2020-04-01

Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells
Redox Biology, 20, 321-333, 2019-01-01
[ Bhlhe40 , Oxidative metabolism , Peroxisome , PGC-1α , Skeletal muscle ]

Thyroid hormone protects hepatocytes from HBx-induced carcinogenesis by enhancing mitochondrial turnover
Oncogene, 36, 37, 5274-5284, 2017-09-14

Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy
Autophagy, 12, 12, 2271-2285, 2016-12-01
[ DAPK2 , HCC , selective autophagy , SQSTM1/p62 , THR ]

Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway
Cell Death and Disease, 7, 8, 2016-08-04

Transduction of recombinant M3-p53-R12 protein enhances human leukemia cell apoptosis
, 7, 10, 1360-1373, 2016-01-01
[ And protein drug , Apoptosis , Cancer , Leukemia , MyoD , P53 ]

Wnt3a signal pathways activate MyoD expression by targeting cis-elements inside and outside its distal enhancer
Bioscience Reports, 35, 2015-02-05
[ Muscle , MyoD , Myogenesis , Pax7 , Wnt3a , β-catenin ]

Bhlhe40 represses PGC-1α activity on metabolic gene promoters in myogenic cells
Molecular and Cellular Biology, 35, 14, 2518-2529, 2015-01-01

Perturbation of cytosolic calcium by 2-aminoethoxydiphenyl borate and caffeine affects zebrafish myofibril alignment
, 35, 3, 287-294, 2015-01-01
[ Caffeine , Calcium , Embryogenesis , Myogenesis , Zebrafish ]

Valproic acid enhances Oct4 promoter activity through PI3K/Akt/mTOR pathway activated nuclear receptors
Molecular and Cellular Endocrinology, 383, 1-2, 147-158, 2014-03-05
[ Akt , IPSC , Muscle , Nuclear receptor , Oct4 , VPA ]

Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts
PLoS ONE, 9, 2, 2014-02-13

Double homeobox gene, Duxbl, promotes myoblast proliferation and abolishes myoblast differentiation by blocking MyoD transactivation
Cell and Tissue Research, 358, 2, 551-566, 2014-01-01
[ Double homeobox gene , Duxbl , Muscle regeneration , Myogenesis , Satellite cells ]

FoxO6 and PGC-1α form a regulatory loop in myogenic cells
Bioscience Reports, 33, 3, 485-500, 2013-07-08
[ FoxO6 , Muscle , Oxidative metabolism , PGC-1α , Promoter , Transcription ]

FoxO6 and PGC-1α form a regulatory loop in myogenic cells.
Bioscience Reports, 33, 3, 2013-01-01

Thyroid hormone receptors promote metastasis of human hepatoma cells via regulation of TRAIL
Cell Death and Differentiation, 19, 11, 1802-1814, 2012-11-01
[ apoptosis , metastasis , thyroid hormone receptor , TRAIL ]

Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis
EMBO Journal, 31, 7, 1739-1751, 2012-04-04
[ Epigenetics , miR-546 , Mybbp1a , MyoD , myogenesis ]

Using isothermal titration calorimetry to real-time monitor the heat of metabolism: A case study using PC12 cells and Aβ(1-40)
Colloids and Surfaces B: Biointerfaces, 83, 2, 307-312, 2011-04-01
[ β-Amyloid , Alzheimer's disease , Biothermodynamics , Isothermal titration calorimetry ]

Valproic acid enhances Oct4 promoter activity in myogenic cells
Journal of Cellular Biochemistry, 110, 4, 995-1004, 2010-07-01
[ Muscle , Oct4 , Pluripotency , RAR , Retinoic acid , VPA ]

Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements
Biochemical Journal, 428, 2, 223-233, 2010-06-01
[ M-cadherin , MyoD , Myogenesis , Myogenic regulatory factor (MRF) , N-cadherin ]

SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α(PGC-1α) gene in skeletal muscle through the PGC-1α autoregulatory loop and interaction with MyoD
Journal of Biological Chemistry, 284, 33, 21872-21880, 2009-08-14

Simultaneous overexpression of Oct4 and Nanog abrogates terminal myogenesis
American Journal of Physiology - Cell Physiology, 297, 1, 2009-07-01
[ Differentiation , Pax7 , Pluripotency , Stem cell ]

Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines
Endocrinology, 149, 8, 3817-3831, 2008-08-01

Myogenic basic helix-loop-helix proteins regulate the expression of peroxisomal proliferator activated receptor-γ coactivator-1α
Endocrinology, 147, 6, 3093-3106, 2006-06-01

Overexpression of SPARC gene in human gastric carcinoma and its clinic-pathologic significance
British Journal of Cancer, 91, 11, 1924-1930, 2004-11-29
[ Gastric cancer , Microarray , Real-time RT-PCR , SPARC ]

Regulation of fibronectin by thyroid hormone receptors
Journal of Molecular Endocrinology, 33, 2, 445-458, 2004-10-01

Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen and coagulation proteins
Endocrinology, 145, 6, 2804-2814, 2004-06-01

Plasma protein regulation by thyroid hormone
Journal of Endocrinology, 179, 3, 367-377, 2003-12-01

Mitogen-activated protein kinases potentiate thyroid hormone receptor transcriptional activity by stabilizing its protein
Endocrinology, 144, 4, 1407-1419, 2003-04-01

p53 is a regulator of the metastasis suppressor gene Nm23-H1
Molecular Carcinogenesis, 36, 4, 204-214, 2003-04-01
[ Metastasis , Nm23-H1 , p53 , Regulation , Suppressor gene ]

Characterization of the retinoid orphan-related receptor-α coactivator binding interface: A structural basis for ligand-independent transcription
Molecular Endocrinology, 16, 5, 998-1012, 2002-05-18

The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2
Journal of Biological Chemistry, 277, 6, 4324-4333, 2002-02-08

SOX18 directly interacts with MEF2C in endothelial cells
Biochemical and Biophysical Research Communications, 287, 2, 493-500, 2001-09-21
[ Endothelial , MEF2C , Protein-protein interaction , Ragged , Sox18 , Transcription , Vasculogenesis ]

Subcellular localization of the steroid receptor coactivators (SRCs) and MEF2 in muscle and rhabdomyosarcoma cells
Molecular Endocrinology, 15, 5, 783-796, 2001-05-17

Impaired interaction of mutant thyroid hormone receptors associated with human hepatocellular carcinoma with transcriptional coregulators
Endocrinology, 142, 2, 653-662, 2001-01-01

The steroid receptor coactivator, GRIP-1, is necessary for MEF-2C- dependent gene expression and skeletal muscle differentiation
Genes and Development, 14, 10, 1209-1228, 2000-05-15
[ Gene expression , GRIP-1 , Myogenic cells , Skeletal muscle differentiation ]

Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells
Molecular Carcinogenesis, 26, 1, 53-61, 1999-09-15
[ Hepatocellular carcinoma , Mutation , Receptor , Thyroid hormone ]

The nuclear receptor corepressor N-CoR regulates differentiation: N-CoR directly interacts with myoD
Molecular Endocrinology, 13, 7, 1155-1168, 1999-01-01

The gene regulating activity of thyroid hormone nuclear receptors is modulated by cell-type specific factors
Biochemical and Biophysical Research Communications, 238, 2, 280-284, 1997-09-18

Dominant negative activity of mutant thyroid hormone receptors from patients with hepatocellular carcinoma
Endocrinology, 138, 12, 5308-5315, 1997-01-01