教師個人簡歷
現職
國立中央大學
生醫理工學院生醫科學與工程學系
教授
專長
微型RNA應用
疾病偵測指標
新型藥物研發
腫瘤治療
microRNA
cancer biology
Disease Mechanism
專長簡述
微型RNA、 癌症生物學、訊息傳遞網路、藥物研發
最高學歷
美國 Yale University
Experimental Pathology
博士
科技部學門領域
政府GRB研究專長領域
教育部學門領域
高教深耕計畫
-
利用次世代基因序列分析洗腎病人冠心症之微型核醣核酸疾病標記
1140101~1141231
-
研究miR-148a-3p應用於放射治療預後生物標記及頭頸癌的放射增敏劑
1130801~1131231
[微型RNA , miRNA] -
微型RNA在頭頸癌放射線治療中的應用I
1120801~1121231
[微型RNA , miRNA] -
腹膜細胞纖維化對腹膜透析病人之影響
1120101~1121231
[腹膜硬化症 , Encapsulating peritoneal sclerosis] -
微型RNA在頭頸癌放射線治療中的應用I
1110601~1111231
-
建立對長期透西病人發生泌尿道腫瘤的監測系統(Ⅰ)
1080101~1081231
國科會計畫統計
-
探討微型RNA在頭頸癌中增強放射治療敏感及其微環境之間的調控及影響
1130801~1140731
[放射治療敏感度 , Radiotherapy sensitization] -
探討微型RNAs在黑色素瘤與微環境中免疫細胞及角質形成細胞相互作用之影響
1120801~1130731
[微型RNA , miRNA] -
探討MAPK/ERK訊息傳遞相關之新穎微型RNA在黑色素瘤中BRAF抑制劑之抗藥性及其微環境之調控及作用(3/3)
1110801~1120731
[微型RNA , miRNA] -
探討MAPK/ERK訊息傳遞相關之新穎微型RNA在黑色素瘤中BRAF抑制劑之抗藥性及其微環境之調控及作用(2/3)
1100801~1110731
[黑色素瘤 , Melanoma] -
科研創業計畫:早期篩檢慢性腎臟病及洗腎病人罹患泌尿道上皮癌之檢測套組
1100101~1101231
[泌尿道上皮癌 ] -
探討MAPK/ERK訊息傳遞相關之新穎微型RNA在黑色素瘤中BRAF抑制劑之抗藥性及其微環境之調控及作用(1/3)
1090801~1100731
[訊息傅遞路徑,微型RNA,腫瘤,黑色素癌,生物標記,BRAF , Signaling transduction,MAPK/ERK signaling,MicroRNA,Melanoma,Biomarkers,BRAF] -
探討MAPK/ERK 訊息傳遞相關之新穎微型RNA在黑色素瘤和PLX4032抗藥性之調控及作用
1080801~1090731
[訊息傅遞路徑, 微型RNA, 腫瘤, 黑色素癌,生物標記 , Signaling transduction, Tumor progression, MAPK/ERK signaling, microRNA, melanoma, Biomarkers] -
開發以血中微型RNA為主來預測三年內患得急性冠心症(ACS)的疾病指標
1071101~1081031
[急性冠心症,生物標記,微型核糖核酸 , Acute coronary syndrome,Biomarker, microRNA] -
探討MAPK/ERK 訊息傳遞相關之新穎微型RNA在黑色素瘤和PLX4032抗藥性之調控及作用
1070801~1080731
[訊息傅遞路徑, 微型RNA, 腫瘤, 黑色素癌,生物標記 , Signaling transduction, Tumor progression, MAPK/ERK signaling, microRNA, melanoma, Biomarkers] -
探討MAPK/ERK 訊息傳遞相關之新穎微型RNA在黑色素瘤和PLX4032抗藥性之調控及作用
1060801~1070731
[訊息傅遞路徑, 微型RNA, 腫瘤, 黑色素癌,生物標記 , Signaling transduction, Tumor progression, MAPK/ERK signaling, microRNA, melanoma, Biomarkers]
產學合作計畫統計
-
113年中大聯新醫院聯合研發中心計畫-研究miR-148a-3p應用於放射治療預後生物標記及頭頸癌的放射增敏劑
1130801~1140731
[微型RNA , miRNA] -
112年中大聯新醫院聯合研發中心計畫-微型RNA在頭頸癌放射線治療中的應用I
1120801~1130731
[微型RNA , miRNA] -
111年中大聯新醫院聯合研發中心計畫-微型RNA在頭頸癌放射線治療中的應用I
1110601~1120731
[微型RNA , miRNA] -
109年中大聯新醫院聯合研發中心計畫-探討在體液中微型RNA調控泌尿道上皮癌中的機制和功能
1090401~1100331
[微型RNA , miRNA] -
利用次世代基因序列分析篩選出預測洗腎病人得冠心症之微型核醣核酸疾病標記II
1081101~1091031
[微型核醣核酸 , miRNA] -
建立對長期透西病人發生泌尿道腫瘤的監測系統(Ⅰ)
1080401~1090331
-
開發以血中微型RNA為主來預測三年內患得急性冠心症(ACS)的疾病指標
1071101~1081031
[急性冠心症,生物標記,微型核糖核酸 , Acute coronary syndrome,Biomarker, microRNA] -
利用次世代基因序列分析篩選出預測洗腎病人得冠心症之微型核醣核酸疾病標記
1070901~1080831
-
建立對長期透西病人發生泌尿道腫瘤的監測系統(Ⅰ)
1070401~1080331
-
發展新的簡易RAN萃取方法及建立長期透析病人發生泌尿道上皮癌監測系統
1060701~1070630
-
建立對長期透析病人發生泌尿道腫瘤的監測系統(1)
1060101~1070331
-
以偵測 miRNA 為基礎用於 Delta All in one qPCR 儀器及開發放射線治療抗性及預後治療的生物標記
1050101~1051231
-
利用原位雜合技術發展中性去氧核醣核酸用於偵測微型RAN
1050101~1051231
-
製備高純度之NCU179 酵素
1040101~1041231
期刊著作
-
MicroRNA regulators of vascular pathophysiology in chronic kidney disease
Clinica Chimica Acta, 551, 2023-11-01
[ Chronic kidney disease,Coronary artery disease,MicroRNA ] -
Peritoneal effluent MicroRNA profile for detection of encapsulating peritoneal sclerosis
Clinica Chimica Acta, 536, 45-55, 2022-11-01
[ Biomarker,Encapsulating peritoneal sclerosis,microRNA,Peritoneal dialysis ] -
Mirna as a modulator of immunotherapy and immune response in melanoma
Biomolecules, 11, 11, 2021-11-01 -
The MicroRNA Prediction Models as Ancillary Diagnosis Biomarkers for Urothelial Carcinoma in Patients With Chronic Kidney Disease
Frontiers in Medicine, 8, 2021-10-01
[ biofluid,biomarker,chronic kidney disease,microRNA (miRNA),urothelial carcinoma (UC) ] -
miR-524-5p reduces the progression of the BRAF inhibitor-resistant melanoma
Neoplasia, 22, 12, 789-799, 2020-12-01
[ BRAF inhibitor,Melanoma,miR-524-5p,miRNA,Resistance ] -
CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway
Cells, 9, 7, 2020-07-16
[ BMAC,BRAK,cell cycle,CXCL14,human embryonic stem cell,IGF-1R,Mip-2γ,self-renewal ] -
Plasma miRNA profile is a biomarker associated with urothelial carcinoma in chronic hemodialysis patients
American Journal of Physiology - Renal Physiology, 316, 6, F1094-F1102, 2019-06-01
[ Biomarker , Chronic hemodialysis , MicroRNA , Urothelial carcinoma ] -
CCM111 prevents hepatic fibrosis via cooperative inhibition of TGF-β Wnt and STAT3 signaling pathways
Journal of Food and Drug Analysis, 27, 1, 184-194, 2019-01-01
[ Antrodia cinnamomea , Liver fibrosis , STAT3 pathway , TGF-β pathway , Wnt pathway ] -
MicroRNA expression pattern as an ancillary prognostic signature for radiotherapy 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis
Journal of Translational Medicine, 16, 1, 2018-12-05
[ Biomarkers,Cancer,microRNAs,Prognosis,Radiotherapy ] -
miR-596 Modulates Melanoma Growth by Regulating Cell Survival and Death
Journal of Investigative Dermatology, 138, 4, 911-921, 2018-04-01 -
CCM111, the water extract of Antrodia cinnamomea, regulates immune-related activity through STAT3 and NF-κB pathways
Scientific Reports, 7, 1, 2017-12-01 -
Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions
Scientific Reports, 6, 2016-09-06 -
Cytotoxicity of Postmodified Zeolitic Imidazolate Framework-90 (ZIF-90) Nanocrystals: Correlation between Functionality and Toxicity
Chemistry - A European Journal, 22, 9, 2925-2929, 2016-02-24
[ cytotoxicity , drug carriers , metal-organic frameworks , post-modification , ZIF-90 ] -
Novel expression and regulation of TIMP-1 in Epstein Barr virus-infected cells and its impact on cell survival
Virology, 481, 24-33, 2015-07-01
[ Apoptosis , EBV , LCL , TIMP-1 , Zta ] -
Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells
Cell Cycle, 14, 8, 1207-1217, 2015-04-15 -
MicroRNA regulation of DNA repair gene expression in 4-aminobiphenyl-treated HepG2 cells
Toxicology, 322, 69-77, 2014-08-01
[ DNA damage,DNA repair,MiRNA-513a-5p,MiRNA-630 ] -
MiR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation
Stem Cell Research, 12, 2, 338-353, 2014-03-01 -
Functional Module Connectivity Map (FMCM): A framework for searching repurposed drug compounds for systems treatment of cancer and an application to colorectal adenocarcinoma
PLoS ONE, 9, 1, 2014-01-27 -
miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2
, 5, 19, 9444-9459, 2014-01-01
[ BRAF , ERK2 , MAPK signaling , Melanoma , MicroRNA , miR-524-5p ] -
A green and facile approach to obtain 100 nm zeolitic imidazolate framework-90 (ZIF-90) particles via leveraging viscosity effects
RSC Advances, 4, 95, 52883-52886, 2014-01-01 -
5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis
Journal of Functional Foods, 11, C, 528-537, 2014-01-01
[ 5-Demethyltangeretin , DMBA , Inflammation , Tangeretin , TPA ] -
Global assessment of Antrodia cinnamomea-induced microRNA alterations in hepatocarcinoma cells
PLoS ONE, 8, 12, 2013-12-17 -
Array-Based High-Throughput Screening UNIT 5C.3 in Mouse Embryonic Stem Cells with shRNAs
Current Protocols in Stem Cell Biology, 1, SUPPL.26, 2013-01-01
[ Embryonic stem cells , High-throughput screening , RNA interference , Short-hairpin RNA ] -
Phyto-power dietary supplement potently inhibits dimethylnitrosamine- induced liver fibrosis in rats
Food and Function, 4, 3, 470-475, 2013-01-01 -
A shRNA functional screen reveals Nme6 and Nme7 are crucial for embryonic stem cell renewal
Stem Cells, 30, 10, 2199-2211, 2012-10-01
[ Embryoid body , Embryonic stem cells , Pluripotency , Teratoma ] -
Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice
Journal of Agricultural and Food Chemistry, 60, 13, 3441-3451, 2012-04-04
[ colitis , DSS , IBD , NFκB , Nrf-2 ] -
Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs
Science Signaling, 3, 109, 2010-02-16 -
Regulation of the Rad53 protein kinase in signal amplification by oligomer assembly and disassembly
Cell Cycle, 7, 6, 808-817, 2008-03-15
[ Activation mechanism , DNA damage checkpoint , Kinase , Oligomer , Rad53 ] -
Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1
Journal of Biological Chemistry, 281, 7, 3954-3963, 2006-02-17 -
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks
Molecular and Cellular Biology, 25, 10, 3934-3944, 2005-05-01 -
Yeast Mre11 and Rad1 Proteins Define a Ku-Independent Mechanism to Repair Double-Strand Breaks Lacking Overlapping End Sequences
Molecular and Cellular Biology, 23, 23, 8820-8828, 2003-12-01
研討會著作
-
MicroRNAs Involved in Peritoneal Fibrosis
2022-03-25
[ microRNAs,Peritoneal Fibrosis ] -
BRAF inhibitor-induced tumorigenesis via extracellular vesicles in the tumor microenvironment
2022-03-25
[ BRAF inhibitor,Tumor microenvironment,Extracellular vesicles ] -
Tamoxifen reduces high glucose-induced mesothelial- to-mesenchymal transition
2022-03-25
[ Tamoxifen,Mesothelial- to-mesenchymal transition ] -
miR-148a-3p expression induces radiosensitivity and reduces bystander effects in head and neck cancer cells
2022-03-25
[ microRNAs,Radiosensitivity,Bystander effects,Head and neck cancer ] -
The microRNA classifiers as ancillary diagnosis biomarkers of urothelial carcinoma for dialysis patients
2022-03-12
[ microRNAs,biomarker,urothelial carcinoma ] -
The miRNA profile as an ancillary diagnosis biomarker for coronary artery disease
2022-03-12
[ microRNAs,biomarker,coronary artery disease ] -
Methylglyoxal induces peritoneal fibrosis and angiogenesis in rat peritoneal dialysis model
2021-11-26
[ Methylglyoxal,peritoneal dialysis ] -
miR-567 modulates the Progression of Melanoma Cells through targeting IGF1R, E2F and Cyclin B2
2021-09-04
[ microRNAs,Melanoma ] -
miR-148a-3p: potential targets for the development of radiosensitizer
2021-09-04
[ microRNAs,radiosensitizer ] -
miR-524-5p reduces the progression of the BRAF inhibitor-resistance melanoma
2020-08-16
[ microRNAs,melanoma ] -
The intercellular communication involves in BRAF inhibitor -induced tumorigenesis
2020-08-16
[ BRAF inhibitor ] -
The microRNA classifiers as ancillary diagnosis biomarkers of urothelial carcinoma for chronic kidney disease
2020-02-05
[ microRNAs,biomarker,urothelial carcinoma ] -
miR-524-5p suppresses the progression of the BRAF inhibitor resistance in melanoma
2020-02-05
[ microRNAs,melanoma ] -
Identifying MiRNA Biomarkers for Diagnosis of Encapsulating Peritoneal Sclerosis
2019-11-05
[ microRNAs,biomarker,Encapsulating Peritoneal Sclerosis ] -
miR-524-5p blocks the progression of BRAF inhibitor-resistance melanoma cells through MAPK/ERK and PI3K/AKT signaling pathways
2019-05-04
[ microRNAs,melanoma ] -
The microRNA classifiers as ancillary diagnosis biomarkers of urothelial carcinoma for chronic kidney disease patients
2019-05-04
[ microRNAs,biomarker,urothelial carcinoma ] -
Urothelial carcinoma-related miRNAs regulate bladder cancer cell functions
2019-03-23
[ microRNAs,Urothelial carcinoma ] -
The miRNAs in extracellular vesicles (EVs) involve in radiation-induced bystander effects
2019-03-23
[ microRNAs,extracellular vesicles,bystander effects ] -
miR-524-5p blocks the progression of BRAF inhibitor-resistance melanoma cells through MAPK/ERK and PI3K/AKT signaling pathways
2019-03-23
[ microRNAs,melanoma ] -
The microRNAs signature as ancillary diagnosis biomarker for urothelial carcinoma for chronic kidney disease patients
2018-03-24
[ microRNAs,urothelial carcinoma,biomarker ] -
The microRNAs signature as ancillary diagnosis biomarker for urothelial carcinoma in dialysis patients
2018-03-24
[ microRNAs,urothelial carcinoma,biomarker ] -
The miRNA classifier as the ancillary prognostic biomarker for radiotherapy, Radiation Break-through: from DNA damage responses to precision cancer therapy
2018-03-12
[ miRNA,radiotherapy,biomarker ] -
Peracetylated epigallocatechin-3-gallate effectively prevents human breast cancer cell metastasis by targeting the matrix metalloproteinases activity and fatty acid synthase expression
291-302, 2013-01-01
校外榮譽
- 111 [經濟部] 台灣創新技術博覽會-金牌獎
- 110 [財團法人生技醫療科技政策研究中心] 第18屆國家新創獎-學研新創獎
- 110 [經濟部] 台灣創新技術博覽會-銀牌獎
- 110 [桃園市政府] 桃園市創意發明家
- 109 [經濟部] 台灣創新技術博覽會-鉑金獎
校內獲獎
- 112 研究傑出獎
- 111 研究傑出獎
- 110 研究傑出獎
- 109 研究傑出獎
- 108 研究傑出獎
- 107 研究傑出獎
- 106 研究傑出獎
- 105 研究傑出獎
- 泌尿上皮癌的檢測套組及檢測方法 [中國]
- 評估個體罹患腹膜硬化症之風險的方法,其分析器及套組 [美國]
- 評估個體罹患腹膜硬化症之風險的方法,其分析器及套組 [中華民國]
- 泌尿上皮癌的檢測套組及檢測方法Method for treating urothelial carcinoma [美國]
- 評估個體罹患泌尿上皮癌之風險的方法及其套組 [中華民國]
- ANALYZER AND ANALYTICAL METHOD FOR PREDICTING PROGNOSIS OF CANCER RADIOTHERAPY [美國]
- 泌尿上皮癌的檢測套組及檢測方法 [中華民國]
- 預測癌症放射線治療之預後的分析器及方法 [中華民國]
國立中央大學