教師個人簡歷
現職
國立中央大學
生醫理工學院生醫科學與工程學系
教授 (兼任)
專長
癌症生物學
基質生物學
專長簡述
胚胎發育、癌症系統生物學
最高學歷
Medical University of South Carolina
Molecular Biology
博士
教育部學門領域
其他補助
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細胞新陳代謝異常與內質網壓力造成腎細胞癌發生之關係研究
1100101~1100731
[腎臟細胞癌 , Renal cell carcinoma] -
109年度「生醫產業與新農業跨領域人才培育計畫」之A類「生醫產業與新農業學產研鏈結人才培育計畫」智慧創新高值醫材夥伴學校
1090201~1100131
[高值醫材 ] -
細胞新陳代謝異常與內質網壓力造成腎細胞癌發生之關係研究
1090101~1091231
[腎臟細胞癌,內質網壓力,組織發炎 , Renal cell carcinoma,Endoplasmic reticulum pressure,Tissue inflammation] -
108年度「生醫產業與新農業跨領域人才培育計畫」- A類「生醫產業與新農業學產研鏈結人才培育計畫」夥伴學校-智慧高值創新醫材領域
1080201~1090131
-
細胞新陳代謝異常與內質網壓力造成腎細胞癌發生之關係研究
1080101~1081231
[腎臟癌,發炎,內質網壓力 , kidney cancer,inflammation,ER stress] -
107年度「生醫產業與新農業跨領域人才培育計畫」- A類「生醫產業與新農業學產研鏈結人才培育計畫」夥伴學校-智慧高值創新醫材領域
1070314~1080131
-
發炎與癌症發生之關係之研究:腎臟細胞癌模式
1070101~1071231
[kindy cancer,inflammation ] -
發炎與癌症發生之關係之研究:腎臟細胞癌模式
1060101~1061231
[kindy cancer,inflammation ] -
遠距照護產學實驗基地-生醫理工學院與產業及醫院共同研發平台
1050301~1060228
-
發炎與癌症發生之關係之研究:腎臟細胞癌模式
1050101~1051231
[kindy cancer,inflammation ]
高教深耕計畫
-
中大聯新慢性病研究中心
1090101~1091231
-
生醫理工學院-整合型計畫
1080101~1081231
-
智慧系統-關懷科技特色領域(智慧健康照護、智慧計算)
1080101~1081231
-
中大聯新慢性病研究中心
1080101~1081231
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整合型世代研究:糖尿病、腎病變與動派硬化之分子機轉
1080101~1081231
-
智慧系統-關懷科技特色領域(智慧健康照護、智慧計算)
1080101~1081231
-
生醫理工學院-學院型整合計畫
1070101~1071231
-
智慧系統-關懷科技特色領域(智慧健康照護、智慧計算)
1070101~1071231
-
智慧系統-關懷科技特色領域(智慧健康照護、智慧計算)
1070101~1071231
捐(受)贈收入
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TBF生技獎座學術研究及人才培育及發展計畫
1030101~9991231
國科會計畫統計
-
腎細胞癌發生過程中發炎微環境與腫瘤細胞之互動
1110801~1120731
[腎細胞癌,腫瘤微環境,巨噬細胞,發炎 , renal cell carcinoma, tumor microenvironment, macrophage, inflammation] -
腎細胞癌發生過程中發炎微環境與腫瘤細胞之互動
1100801~1110731
[腎細胞癌,腫瘤微環境,巨噬細胞,發炎 , renal cell carcinoma, tumor microenvironment, macrophage, inflammation] -
腎細胞癌發生過程中發炎微環境與腫瘤細胞之互動
1090801~1100731
[腎細胞癌,腫瘤微環境,巨噬細胞,發炎 , renal cell carcinoma, tumor microenvironment, macrophage, inflammation] -
單細胞層級之腎臟巨噬細胞族群分析—腎臟發炎及癌症標靶之探索
1080801~1090731
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缺氧腫瘤細胞與腫瘤微環境互動之研究
1080801~1090731
-
單細胞層級之腎臟巨噬細胞族群分析—腎臟發炎及癌症標靶之探索
1070801~1080731
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缺氧腫瘤細胞與腫瘤微環境互動之研究
1070801~1080731
-
單細胞層級之腎臟巨噬細胞族群分析—腎臟發炎及癌症標靶之探索
1060801~1070731
-
缺氧腫瘤細胞與腫瘤微環境互動之研究
1060801~1070731
產學合作計畫統計
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整合型世代研究:糖尿病、腎病變與動派硬化之分子機轉
1080401~1090331
-
2019 生醫工程應用研討會
1080227~1080403
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2019生醫工程應用研討會校補助
1080101~1080430
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中大壢新慢性病研究中心
1060101~1061231
期刊著作
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Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma
Journal of Biomedical Science, 32, 1, 2025-12-01
[ Cancer stem cells,Clear-cell renal cell carcinoma,Kidney progenitor cells,Metastasis-initiating cells,Tumor-initiating cells,VHL tumor suppressor gene ] -
Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells
Communications Biology, 8, 1, 2025-12-01 -
Controlled Plasma Membrane Delivery of FGFR1 and Modulation of Signaling by a Novel Regulated Anterograde RTK Transport Pathway
Cancers, 15, 24, 2023-12-01
[ FGFR1,RART pathway,receptor trafficking,RTK signaling,solid tumors ] -
IL6 and CCL18 Mediate Cross-talk between VHL-Deficient Kidney Cells and Macrophages during Development of Renal Cell Carcinoma
Cancer Research, 82, 15, 2716-2733, 2022-08-01 -
Cardiac-specific microRNA-125b deficiency induces perinatal death and cardiac hypertrophy
Scientific Reports, 11, 1, 2021-12-01 -
Endothelial reprogramming stimulated by oncostatin M promotes inflammation and tumorigenesis in VHL-deficient kidney tissue
Cancer Research, 81, 19, 5060-5073, 2021-10-01 -
Kidney pericyte hypoxia-inducible factor regulates erythropoiesis but not kidney fibrosis
Kidney International, 99, 6, 1354-1368, 2021-06-01
[ erythropoietin,fibrosis,hypoxia-inducible factor,pericyte ] -
Loss of Function of von Hippel-Lindau Trigger Lipocalin 2-Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells
Oxidative Medicine and Cellular Longevity, 2021, 2021-01-01 -
Cloud-Based Artificial Intelligence System for Large-Scale Arrhythmia Screening
Computer, 52, 11, 40-51, 2019-11-01 -
Active roles of dysfunctional vascular endothelium in fibrosis and cancer
Journal of Biomedical Science, 26, 1, 2019-10-28
[ Cancer vasculature , Endothelial cells , Fibrosis , Inflammation ] -
Gamma-aminobutyric acid decreases macrophages infiltration and suppresses inflammatory responses in renal injury
Journal of Functional Foods, 60, 2019-09-01
[ Gamma-aminobutyric acid , Macrophage infiltration , Monocyte chemotactic protein-1/C-C motif chemokine receptor 2 axis , Von Hippel-Lindau ] -
Vps28 is involved in the intracellular trafficking of AWD, the Drosophila homolog of NMe1/2
Frontiers in Physiology, 10, JUL, 2019-01-01
[ ALiX , Awd/NME , Drosophila , ESCRT machinery , Fat body , Intracellular trafficking , Metastasis suppressor genes , Vps28 ] -
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
Nature Communications, 9, 1, 2018-12-01 -
Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation
Physical Review Letters, 121, 1, 2018-07-03 -
Extracellular NME proteins: A player or a bystander?
Laboratory Investigation, 98, 2, 248-257, 2018-02-01 -
VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress–activated IRE1α signaling
Cancer Research, 77, 13, 3406-3416, 2017-07-01 -
Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein
, 389, 11, 1171-1182, 2016-11-01
[ Awd/Nme , Endocytosis , Shibire/Dynamin , Tumour suppressor gene ] -
Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model
BMC Cancer, 16, 1, 2016-10-12
[ Angiogenesis , Extramedullary erythropoiesis , Hemangioblastoma , Hemangioma , Hypoxia-inducible factor 2 alpha , Neutrophil , Placental growth factor , Von Hippel-Lindau ] -
Characterization of fungal and bacterial components in gut/fecal microbiome
Current Drug Metabolism, 16, 4, 272-283, 2015-09-01
[ Bacteria , Feces , Fungi , Gut , Human , Microbiome ] -
Conditional inactivation of the mouse von Hippel-Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney
Oncogene, 34, 20, 2631-2639, 2015-05-14 -
Interaction between Nm23 and the tumor suppressor VHL
, 388, 2, 143-152, 2015-02-01
[ Endocytosis , Nm23 , Tumor suppressor gene , von Hippel-Lindau ] -
Progress on Nme (NDP kinase/Nm23/awd) gene family-related functions derived from animal model systems: Studies on development, cardiovascular disease, and cancer metastasis exemplified
Naunyn-Schmiedeberg's Archives of Pharmacology, 388, 2, 109-117, 2015-01-01 -
Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23
BMC Biology, 12, 2014-02-14
[ Awd , Endocytosis , Notch signaling ] -
Systemic VHL gene functions and the VHL disease
FEBS Letters, 586, 11, 1562-1569, 2012-06-04
[ Erythropoietin , Haploid insufficiency , Hemangioblastoma , Hematopoiesis , Inflammation ] -
Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: Insights from model organisms
Oncogene, 31, 18, 2247-2257, 2012-05-03
[ HIF , model organisms , VHL ] -
Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells
International Journal of Cancer, 130, 3, 532-543, 2012-02-01 -
NME genes in epithelial morphogenesis
, 384, 4-5, 363-372, 2011-10-01
[ Awd , Drosophila , Epithelial morphogenesis , Follicle cell , NME genes , Trachea ] -
Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis
Molecular and Cellular Biology, 30, 15, 3779-3794, 2010-08-01 -
Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability
Development (Cambridge), 137, 9, 1493-1503, 2010-05-01
[ Drosophila , Epithelial morphogenesis , Von Hippel-Lindau tumor-suppressor gene ] -
The Drosophila metastasis suppressor gene Nm23 homolog, awd, regulates epithelial integrity during oogenesis
Molecular and Cellular Biology, 29, 17, 4679-4690, 2009-09-01 -
Developmental function of Nm23/awd: A mediator of endocytosis
Molecular and Cellular Biochemistry, 329, 1-2, 35-44, 2009-04-17
[ Awd , Drosophila , Killer-of-prune , Nm23 , Prune ] -
Hypoxia-inducible factor-2α regulates the expression of TRAIL receptor DR5 in renal cancer cells
Carcinogenesis, 29, 9, 1734-1741, 2008-09-22 -
Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway
Journal of Biological Chemistry, 283, 28, 19593-19602, 2008-07-11 -
Endothelial function of von Hippel-Lindau tumor suppressor gene: Control of fibroblast growth factor receptor signaling
Cancer Research, 68, 12, 4649-4657, 2008-06-15 -
Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells
Carcinogenesis, 29, 4, 696-703, 2008-04-01 -
awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion
Molecular and Cellular Biology, 28, 6, 1964-1973, 2008-03-01 -
Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis
Developmental Biology, 308, 1, 30-43, 2007-08-01
[ Breathless , Catsup , Dopamine , Drosophila , Endocytosis , GTP cyclohydrolase , Pale , Punch , Trachea , Tyrosine hydroxylase ] -
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility
Journal of Biological Chemistry, 281, 17, 12069-12080, 2006-04-28 -
Analysis of the hypoxia-sensing pathway in Drosophila melanogaster
Biochemical Journal, 393, 2, 471-480, 2006-01-15
[ Drosophila melanogaster , Hypoxia , Prolyl hydroxylase , Tissue specificity , Von Hippel Lindau ] -
RNA-dependent integrin α3 protein localization regulated by the Muscleblind-like protein MLP1
Nature Cell Biology, 7, 12, 1140-1147, 2005-12-01 -
Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis
Cancer Research, 65, 16, 7205-7213, 2005-08-15 -
dAkt kinase controls follicle cell size during Drosophila oogenesis
Developmental Dynamics, 232, 3, 845-854, 2005-03-01
[ Cell growth , dAkt , Drosophila , Follicle cells , Oogenesis ] -
Site-directed mutagenesis using Pfu DNA polymerase and T4 DNA ligase
BioTechniques, 38, 6, 864-868, 2005-01-01 -
Ets proteins in biological control and cancer
Journal of Cellular Biochemistry, 91, 5, 896-903, 2004-12-01
[ Cancer , ECM , EMT , Epithelium , Ets , Invasion , Metastasis , Stroma , Transcriptional regulation ] -
Developmental expression pattern of D-ets4, the Drosophila homologue of human Pdef
Gene Expression Patterns, 5, 2, 285-289, 2004-12-01
[ D-ets4 , Drosophila , Pdef , Primordial germ cells , Transcription factors ] -
Coordinated functions of Akt/PKB and ETS1 in tubule formation
FASEB Journal, 17, 15, 2278-2280, 2003-12-01 -
Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development
Genes and Development, 17, 22, 2812-2824, 2003-11-15
[ awd/nm23 , Btl/FGFR , Cell migration , Drosophila , shi/dynamin , Tracheal development ] -
EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis
Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, 272, 1, 377-382, 2003-05-01
[ Drosophila , EGF receptor , Follicle cell , MAP kinase , Oogenesis ] -
The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development
Mechanisms of Development, 117, 1-2, 265-268, 2002-09-01
[ CF2 , Drosophila , MEF2 , Myogenesis , Transcription factors , Zinc finger ] -
Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis
Nature Cell Biology, 3, 6, 538-543, 2001-06-26 -
Sequence and functional properties of Ets genes in the model organism Drosophila
Oncogene, 19, 55, 6409-6416, 2000-12-18
[ D-elg , Drosophila , E74 , Ets , Pointed , Yan ] -
Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
Oncogene, 19, 24, 2803-2811, 2000-06-01
[ Drosophila , Tracheal development , Vascularization , VHL ] -
Oogenic function of the myogenic factor D-MEF2: Negative regulation of the decapentaplegic receptor gene thick veins
Proceedings of the National Academy of Sciences of the United States of America, 96, 21, 11889-11894, 1999-10-12 -
Murine Hoxc-9 gene contains a structurally and functionally conserved enhancer
Developmental Dynamics, 212, 4, 540-547, 1998-08-01
[ Central nervous system , Conservation , Enhance , Hoxc-9 , Intron , Transgenic ] -
Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: Cytoplasmic retention and degradation
Genes and Development, 12, 8, 1166-1175, 1998-04-15
[ Dorsoventral patterning , Egfr signaling , MAP kinase , Post-translational regulation ] -
Divergence of a DNA replication gene cluster in the T4-related bacteriophage RB69
Journal of Bacteriology, 180, 8, 2005-2013, 1998-01-01 -
The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis
Mechanisms of Development, 65, 1-2, 197-208, 1997-07-01
[ Drosophila , Oogenesis , TGF-α ] -
The transcription factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis
Genes and Development, 10, 11, 1411-1421, 1996-01-01
[ Dorsoventral patterning , EGF receptor signaling , oogenesis , transcription repression ] -
A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus
Proceedings of the National Academy of Sciences of the United States of America, 90, 14, 6488-6492, 1993-07-15
[ Drosophila nucleolar factor , Single-strand binding factor ] -
Alternatively Spliced Isoforms of a Cis2‐His2 Zinc‐Finger Domain: Developmental Regulation and Binding‐Site Selection
Annals of the New York Academy of Sciences, 684, 1, 218-219, 1993-01-01 -
Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene
Science, 257, 5078, 1946-1950, 1992-01-01 -
Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain
Science, 257, 5078, 1951-1955, 1992-01-01 -
Transcriptional mapping of a DNA replication gene cluster in bacteriophage T4. Sites for initiation, termination, and mRNA processing
Journal of Biological Chemistry, 265, 9, 5303-5316, 1990-04-13 -
DNA polymerase of bacteriophage T4 is an autogenous translational repressor.
Proceedings of the National Academy of Sciences of the United States of America, 85, 21, 7942-7946, 1988-01-01 -
Autogenous regulation of the regA gene of bacteriophage T4: derepression of translation.
Genetics, 119, 4, 743-749, 1988-01-01 -
Identification of two new bacteriophage T4 genes that may have roles in transcription and DNA replication
Journal of Virology, 61, 2, 366-374, 1987-01-01 -
Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation.
Proceedings of the National Academy of Sciences of the United States of America, 84, 22, 7822-7826, 1987-01-01
校內獲獎
- 108 生醫講座
- 105 生醫講座
國立中央大學