國立中央大學教師履歷平台

期刊著作

• Tumor-initiating and metastasis-initiating cells of clear-cell renal cell carcinoma
  Journal of Biomedical Science, 32, 1, 2025-12-01
  [ Cancer stem cells,Clear-cell renal cell carcinoma,Kidney progenitor cells,Metastasis-initiating cells,Tumor-initiating cells,VHL tumor suppressor gene ]

• Oncostatin M induces epigenetic reprogramming in renal cell carcinoma-associated endothelial cells
  Communications Biology, 8, 1, 2025-12-01

• Controlled Plasma Membrane Delivery of FGFR1 and Modulation of Signaling by a Novel Regulated Anterograde RTK Transport Pathway
  Cancers, 15, 24, 2023-12-01
  [ FGFR1,RART pathway,receptor trafficking,RTK signaling,solid tumors ]

• IL6 and CCL18 Mediate Cross-talk between VHL-Deficient Kidney Cells and Macrophages during Development of Renal Cell Carcinoma
  Cancer Research, 82, 15, 2716-2733, 2022-08-01

• Cardiac-specific microRNA-125b deficiency induces perinatal death and cardiac hypertrophy
  Scientific Reports, 11, 1, 2021-12-01

• Endothelial reprogramming stimulated by oncostatin M promotes inflammation and tumorigenesis in VHL-deficient kidney tissue
  Cancer Research, 81, 19, 5060-5073, 2021-10-01

• Kidney pericyte hypoxia-inducible factor regulates erythropoiesis but not kidney fibrosis
  Kidney International, 99, 6, 1354-1368, 2021-06-01
  [ erythropoietin,fibrosis,hypoxia-inducible factor,pericyte ]

• Loss of Function of von Hippel-Lindau Trigger Lipocalin 2-Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells
  Oxidative Medicine and Cellular Longevity, 2021, 2021-01-01

• Cloud-Based Artificial Intelligence System for Large-Scale Arrhythmia Screening
  Computer, 52, 11, 40-51, 2019-11-01

• Active roles of dysfunctional vascular endothelium in fibrosis and cancer
  Journal of Biomedical Science, 26, 1, 2019-10-28
  [ Cancer vasculature , Endothelial cells , Fibrosis , Inflammation ]

• Gamma-aminobutyric acid decreases macrophages infiltration and suppresses inflammatory responses in renal injury
  Journal of Functional Foods, 60, 2019-09-01
  [ Gamma-aminobutyric acid , Macrophage infiltration , Monocyte chemotactic protein-1/C-C motif chemokine receptor 2 axis , Von Hippel-Lindau ]

• Vps28 is involved in the intracellular trafficking of AWD, the Drosophila homolog of NMe1/2
  Frontiers in Physiology, 10, JUL, 2019-01-01
  [ ALiX , Awd/NME , Drosophila , ESCRT machinery , Fat body , Intracellular trafficking , Metastasis suppressor genes , Vps28 ]

• Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
  Nature Communications, 9, 1, 2018-12-01

• Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation
  Physical Review Letters, 121, 1, 2018-07-03

• Extracellular NME proteins: A player or a bystander?
  Laboratory Investigation, 98, 2, 248-257, 2018-02-01

• VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress–activated IRE1α signaling
  Cancer Research, 77, 13, 3406-3416, 2017-07-01

• Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein
  , 389, 11, 1171-1182, 2016-11-01
  [ Awd/Nme , Endocytosis , Shibire/Dynamin , Tumour suppressor gene ]

• Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model
  BMC Cancer, 16, 1, 2016-10-12
  [ Angiogenesis , Extramedullary erythropoiesis , Hemangioblastoma , Hemangioma , Hypoxia-inducible factor 2 alpha , Neutrophil , Placental growth factor , Von Hippel-Lindau ]

• Characterization of fungal and bacterial components in gut/fecal microbiome
  Current Drug Metabolism, 16, 4, 272-283, 2015-09-01
  [ Bacteria , Feces , Fungi , Gut , Human , Microbiome ]

• Conditional inactivation of the mouse von Hippel-Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney
  Oncogene, 34, 20, 2631-2639, 2015-05-14

• Interaction between Nm23 and the tumor suppressor VHL
  , 388, 2, 143-152, 2015-02-01
  [ Endocytosis , Nm23 , Tumor suppressor gene , von Hippel-Lindau ]

• Progress on Nme (NDP kinase/Nm23/awd) gene family-related functions derived from animal model systems: Studies on development, cardiovascular disease, and cancer metastasis exemplified
  Naunyn-Schmiedeberg's Archives of Pharmacology, 388, 2, 109-117, 2015-01-01

• Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23
  BMC Biology, 12, 2014-02-14
  [ Awd , Endocytosis , Notch signaling ]

• Systemic VHL gene functions and the VHL disease
  FEBS Letters, 586, 11, 1562-1569, 2012-06-04
  [ Erythropoietin , Haploid insufficiency , Hemangioblastoma , Hematopoiesis , Inflammation ]

• Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: Insights from model organisms
  Oncogene, 31, 18, 2247-2257, 2012-05-03
  [ HIF , model organisms , VHL ]

• Akt3 controls vascular endothelial growth factor secretion and angiogenesis in ovarian cancer cells
  International Journal of Cancer, 130, 3, 532-543, 2012-02-01

• NME genes in epithelial morphogenesis
  , 384, 4-5, 363-372, 2011-10-01
  [ Awd , Drosophila , Epithelial morphogenesis , Follicle cell , NME genes , Trachea ]

• Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis
  Molecular and Cellular Biology, 30, 15, 3779-3794, 2010-08-01

• Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability
  Development (Cambridge), 137, 9, 1493-1503, 2010-05-01
  [ Drosophila , Epithelial morphogenesis , Von Hippel-Lindau tumor-suppressor gene ]

• The Drosophila metastasis suppressor gene Nm23 homolog, awd, regulates epithelial integrity during oogenesis
  Molecular and Cellular Biology, 29, 17, 4679-4690, 2009-09-01

• Developmental function of Nm23/awd: A mediator of endocytosis
  Molecular and Cellular Biochemistry, 329, 1-2, 35-44, 2009-04-17
  [ Awd , Drosophila , Killer-of-prune , Nm23 , Prune ]

• Hypoxia-inducible factor-2α regulates the expression of TRAIL receptor DR5 in renal cancer cells
  Carcinogenesis, 29, 9, 1734-1741, 2008-09-22

• Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway
  Journal of Biological Chemistry, 283, 28, 19593-19602, 2008-07-11

• Endothelial function of von Hippel-Lindau tumor suppressor gene: Control of fibroblast growth factor receptor signaling
  Cancer Research, 68, 12, 4649-4657, 2008-06-15

• Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells
  Carcinogenesis, 29, 4, 696-703, 2008-04-01

• awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion
  Molecular and Cellular Biology, 28, 6, 1964-1973, 2008-03-01

• Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis
  Developmental Biology, 308, 1, 30-43, 2007-08-01
  [ Breathless , Catsup , Dopamine , Drosophila , Endocytosis , GTP cyclohydrolase , Pale , Punch , Trachea , Tyrosine hydroxylase ]

• Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility
  Journal of Biological Chemistry, 281, 17, 12069-12080, 2006-04-28

• Analysis of the hypoxia-sensing pathway in Drosophila melanogaster
  Biochemical Journal, 393, 2, 471-480, 2006-01-15
  [ Drosophila melanogaster , Hypoxia , Prolyl hydroxylase , Tissue specificity , Von Hippel Lindau ]

• RNA-dependent integrin α3 protein localization regulated by the Muscleblind-like protein MLP1
  Nature Cell Biology, 7, 12, 1140-1147, 2005-12-01

• Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis
  Cancer Research, 65, 16, 7205-7213, 2005-08-15

• dAkt kinase controls follicle cell size during Drosophila oogenesis
  Developmental Dynamics, 232, 3, 845-854, 2005-03-01
  [ Cell growth , dAkt , Drosophila , Follicle cells , Oogenesis ]

• Site-directed mutagenesis using Pfu DNA polymerase and T4 DNA ligase
  BioTechniques, 38, 6, 864-868, 2005-01-01

• Ets proteins in biological control and cancer
  Journal of Cellular Biochemistry, 91, 5, 896-903, 2004-12-01
  [ Cancer , ECM , EMT , Epithelium , Ets , Invasion , Metastasis , Stroma , Transcriptional regulation ]

• Developmental expression pattern of D-ets4, the Drosophila homologue of human Pdef
  Gene Expression Patterns, 5, 2, 285-289, 2004-12-01
  [ D-ets4 , Drosophila , Pdef , Primordial germ cells , Transcription factors ]

• Coordinated functions of Akt/PKB and ETS1 in tubule formation
  FASEB Journal, 17, 15, 2278-2280, 2003-12-01

• Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development
  Genes and Development, 17, 22, 2812-2824, 2003-11-15
  [ awd/nm23 , Btl/FGFR , Cell migration , Drosophila , shi/dynamin , Tracheal development ]

• EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis
  Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, 272, 1, 377-382, 2003-05-01
  [ Drosophila , EGF receptor , Follicle cell , MAP kinase , Oogenesis ]

• The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development
  Mechanisms of Development, 117, 1-2, 265-268, 2002-09-01
  [ CF2 , Drosophila , MEF2 , Myogenesis , Transcription factors , Zinc finger ]

• Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis
  Nature Cell Biology, 3, 6, 538-543, 2001-06-26

• Sequence and functional properties of Ets genes in the model organism Drosophila
  Oncogene, 19, 55, 6409-6416, 2000-12-18
  [ D-elg , Drosophila , E74 , Ets , Pointed , Yan ]

• Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila
  Oncogene, 19, 24, 2803-2811, 2000-06-01
  [ Drosophila , Tracheal development , Vascularization , VHL ]

• Oogenic function of the myogenic factor D-MEF2: Negative regulation of the decapentaplegic receptor gene thick veins
  Proceedings of the National Academy of Sciences of the United States of America, 96, 21, 11889-11894, 1999-10-12

• Murine Hoxc-9 gene contains a structurally and functionally conserved enhancer
  Developmental Dynamics, 212, 4, 540-547, 1998-08-01
  [ Central nervous system , Conservation , Enhance , Hoxc-9 , Intron , Transgenic ]

• Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: Cytoplasmic retention and degradation
  Genes and Development, 12, 8, 1166-1175, 1998-04-15
  [ Dorsoventral patterning , Egfr signaling , MAP kinase , Post-translational regulation ]

• Divergence of a DNA replication gene cluster in the T4-related bacteriophage RB69
  Journal of Bacteriology, 180, 8, 2005-2013, 1998-01-01

• The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis
  Mechanisms of Development, 65, 1-2, 197-208, 1997-07-01
  [ Drosophila , Oogenesis , TGF-α ]

• The transcription factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis
  Genes and Development, 10, 11, 1411-1421, 1996-01-01
  [ Dorsoventral patterning , EGF receptor signaling , oogenesis , transcription repression ]

• A Drosophila single-strand DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus
  Proceedings of the National Academy of Sciences of the United States of America, 90, 14, 6488-6492, 1993-07-15
  [ Drosophila nucleolar factor , Single-strand binding factor ]

• Alternatively Spliced Isoforms of a Cis2‐His2 Zinc‐Finger Domain: Developmental Regulation and Binding‐Site Selection
  Annals of the New York Academy of Sciences, 684, 1, 218-219, 1993-01-01

• Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene
  Science, 257, 5078, 1946-1950, 1992-01-01

• Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain
  Science, 257, 5078, 1951-1955, 1992-01-01

• Transcriptional mapping of a DNA replication gene cluster in bacteriophage T4. Sites for initiation, termination, and mRNA processing
  Journal of Biological Chemistry, 265, 9, 5303-5316, 1990-04-13

• DNA polymerase of bacteriophage T4 is an autogenous translational repressor.
  Proceedings of the National Academy of Sciences of the United States of America, 85, 21, 7942-7946, 1988-01-01

• Autogenous regulation of the regA gene of bacteriophage T4: derepression of translation.
  Genetics, 119, 4, 743-749, 1988-01-01

• Identification of two new bacteriophage T4 genes that may have roles in transcription and DNA replication
  Journal of Virology, 61, 2, 366-374, 1987-01-01

• Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation.
  Proceedings of the National Academy of Sciences of the United States of America, 84, 22, 7822-7826, 1987-01-01