教師個人簡歷
現職
國立中央大學
工學院化學工程與材料工程學系
教授
專長
生醫材料
組織工程
基因療法
控制釋放
Biomedical materials
tissue engineering
gene therapy
controlled release
專長簡述
生醫材料組織工程與再生醫學控制釋放
最高學歷
美國University of Michigan-Ann Arbor
生物醫學工程學系
博士
科技部學門領域
教育部學門領域
高教深耕計畫
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利用生物反應器來模擬肌肉激素在受損肌肉修復及骨骼再生中的影響
1120101~1121231
-
開發可脫附細胞層之彈性導電基材以維持刺激後細胞層的完整性
1100101~1101231
-
開發可脫附細胞層之彈性導電基材以維持刺激後細胞層的完整性
1100101~1101231
其他補助
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108年度U-start創新創業計畫_Nature Fun植物染
1080815~1090214
-
108年度U-start創新創業計畫_T.W.O
1080815~1090214
-
教育部補助大學產業創新研發計畫:具混合實境之醫學可視化技術
1080801~1090731
[具混合實境醫學可視化技術 ]
國科會計畫統計
-
利用多功能生物反應器研究肌肉激素對運動肌肉損傷所引起的發炎和癒合過程之調節機制
1140801~1150731
-
開發多功能生物反應器以研究高血壓造成過度拉伸對血管平滑肌的致病機轉
1130801~1140731
[生物反應器,循環拉伸,電刺激,血管平滑肌細胞,表型轉換,血管疾病 , bioreactor,cyclic stretch,electrical stimulation,vascular smooth muscle cells,phenotypic switching,vascular disease] -
開發水凝膠以支持肌肉細胞片並誘導神經肌肉接合點的形成(II)
1120801~1131031
[開發水凝膠以支持肌肉細胞片並誘導神經肌肉接合點的形成(II) , 開發水凝膠以支持肌肉細胞片並誘導神經肌肉接合點的形成(II)] -
開發水凝膠以支持肌肉細胞片並誘導神經肌肉接合點的形成
1110801~1120731
[水凝膠,生物反應器,細胞片,神經支配,神經營養因子,肌肉組織工程,肌管,萎縮,神經肌肉接點 , hydrogel,bioreactor,cell sheet,innervation,neurotrophic factors,muscle tissue engineering,myotube,atrophy,neuromuscular junction] -
探討兼具拉伸及電刺激之生物反應器於肌肉組織之重建
1100801~1111031
[電刺激,力學刺激,可拉伸導電材料,肌分化,聚吡咯,溫敏性高分子,生物反應器,組織工程,細胞片狀脫附,生物適合性,心肌母細胞 , electrical stimulation,mechanical stimulation,stretchable conductive materials,myogenesis,polypyrrole,thermo-responsive polymer,bioreactor,tissue engineering,cell sheets harvest,biocompatibility,cardiomyoblast] -
探討兼具拉伸及電刺激之生物反應器於肌肉組織之重建
1090801~1100731
[電刺激,力學刺激,可拉伸導電材料,肌分化,聚吡咯,溫敏性高分子,生物反應器,組織工程,細胞片狀脫附,生物適合性,心肌母細胞 , electrical stimulation,mechanical stimulation,stretchable conductive materials,myogenesis,polypyrrole,thermo-responsive polymer,bioreactor,tissue engineering,cell sheets harvest,biocompatibility,cardiomyoblast] -
發明專利申請維護及推廣計畫
1090101~1091231
-
探討兼具拉伸及電刺激之生物反應器於肌肉組織之重建
1080801~1090731
[電刺激,力學刺激,可拉伸導電材料,肌分化,聚吡咯,溫敏性高分子,生物反應器,組織工程,細胞片狀脫附,生物適合性,心肌母細胞 , electrical stimulation,mechanical stimulation,stretchable conductive materials,myogenesis,polypyrrole,thermo-responsive polymer,bioreactor,tissue engineering,cell sheets harvest,biocompatibility,cardiomyoblast] -
開發多功能之複合纖維敷料以應用於糖尿病潰瘍之傷口修復
1070801~1080731
[糖尿病性潰瘍,慢性傷口,傷口敷料,海藻酸鹽,聚乳酸羥基乙酸共聚物,電紡絲,原位轉染,凝血,銀奈米粒子,基因輸送,血小板衍生生長因子,聚乙烯亞胺,傷口癒合 , diabetic ulcer, chronic wound, wound dressing, alginate, poly(lactide-co-glycolide) (PLGA), coelectrospinning, in situ transfection, hemostasis, silver nanoparticles, gene delivery, platelet-derived growth factor (PDGF), polyethylenimine (PEI), wound heal] -
開發Indolicidin之載體系統輸送TNF-α之反義寡核苷酸以治療類風濕性關節炎
1060801~1070731
-
發展可篩選與擴增癌症幹細胞之奈米複合纖維織架
1050801~1060930
-
開發Indolicidin及其衍生物接枝於聚乙烯亞胺之新穎多功能非病毒載體
1040801~1050731
產學合作計畫統計
-
優化材料抗菌性質
1090701~1091031
[優化材料抗菌性質 ] -
109年進駐培育費
1090101~1091231
[進駐,培育 ]
期刊著作
-
Development of a multifunctional bioreactor to evaluate the promotion effects of cyclic stretching and electrical stimulation on muscle differentiation
Bioengineering and Translational Medicine, 9, 2, 2024-03-01
[ bioreactor,cyclic stretching,electrical stimulation,myoblasts,myogenic differentiation,polydimethylsiloxane,polypyrrole ] -
The proliferation and differentiation of skeletal muscle stem cells are enhanced in a bioreactor
Biotechnology and Bioengineering, 2024-01-01
[ bioreactor,differentiation,muscle,myogenesis,proliferation,stem cell ] -
Deposition of polypyrrole on wrinkled polydimethylsiloxane to fabricate stretchable conductive membranes for multifunctional bioreactor applications
Progress in Organic Coatings, 181, 2023-08-01
[ Bioreactor,Cyclic stretching,Electrical stimulation,Myogenic differentiation,Polydimethylsiloxane,Polypyrrole ] -
Bonding of thermoplastic microfluidic device by water assistance
International Journal of Adhesion and Adhesives, 125, 2023-07-01
[ Interfacial heating,Microwave bonding,Multilayer bonding,Water-assisted bonding ] -
Alginate/polycaprolactone composite fibers as multifunctional wound dressings
Carbohydrate Polymers, 289, 2022-08-01
[ Alginate,Composite electrospun fibers,Nano-silver,Platelet-derived growth factor-B,Polycaprolactone,Wound dressing ] -
The development of polylactic acid/multi-wall carbon nanotubes/polyethylene glycol scaffolds for bone tissue regeneration application
Polymers, 13, 11, 2021-06-01 -
Effects of Graphitization and Bonding Configuration in Iron-Nitrogen-Doped Carbon Nanostructures on Surface-Enhanced Raman Scattering
ACS Applied Nano Materials, 3, 1, 858-868, 2020-01-24
[ charge transfer , chemical mechanism , electronic structure , nanostructured carbon , surface-enhanced Raman scattering ] -
Electrical field-assisted gene delivery from polyelectrolyte multilayers
Polymers, 12, 1, 2020-01-01
[ Electrical field , Genedelivery , Layer-by-layer assembly , Polyelectrolytemultilayer , Polypyrrole ] -
Electrical field-assisted gene delivery from polyelectrolyte multilayers
Polymers, 12, 1, 2020-01-01
[ Electrical field,Gene delivery,Layer-by-layer assembly,Polyelectrolyte multilayer,Polypyrrole ] -
Electrical stimulation through conductive substrate to enhance osteo-differentiation of human dental pulp-derived stem cells
Applied Sciences (Switzerland), 9, 18, 2019-09-01
[ Bone morphogenesis proteins,Direct current electric field,Human dental pulp stem cells,Osteo-differentiation,Substrate-mediated electrical stimulation ] -
The effects of substrate-mediated electrical stimulation on the promotion of osteogenic differentiation and its optimization
Journal of Biomedical Materials Research - Part B Applied Biomaterials, 107, 5, 1607-1619, 2019-07-01
[ bone marrow stromal cells , direct-current electric field , osteogenesis , polypyrrole , substrate-mediated electrical stimulation ] -
A novel antimicrobial peptide-derived vehicle for oligodeoxynucleotide delivery to inhibit TNF-α expression
International Journal of Pharmaceutics, 558, 63-71, 2019-03-10
[ Gene silence,Indolicidin,Oligodeoxynucleotides,Peptide dimerization,Tumor necrosis factor-α ] -
The enrichment of cancer stem cells using composite alginate/polycaprolactone nanofibers
Carbohydrate Polymers, 206, 70-79, 2019-02-15
[ Alginate,Cancer stem cells,Cell enrichment,Co-electrospinning,Composite fibers,Tumor niche ] -
Gene immobilization on alginate/polycaprolactone fibers through electrophoretic deposition to promote in situ transfection efficiency and biocompatibility
International Journal of Biological Macromolecules, 121, 1337-1345, 2019-01-01
[ Alginate degradation , Biocompatibility , Coelectrospun composite nanofibers , Electrophoretic deposition , In situ transfection ] -
The control of alginate degradation to dynamically manipulate scaffold composition for in situ transfection application
International Journal of Biological Macromolecules, 117, 1169-1178, 2018-10-01
[ Alginate , Co-electrospinning , Composite nanofibers , Degradation , In situ transfection ] -
A stretchable conductive Polypyrrole Polydimethylsiloxane device fabricated by simple soft lithography and oxygen plasma treatment
Biomedical Microdevices, 20, 2, 2018-06-01
[ Microchannel , Oxygen plasma treatment , Polydimethylsiloxane (PDMS) , Polypyrrole (PPy) ] -
Development of an indolicidin-derived peptide by reducing membrane perturbation to decrease cytotoxicity and maintain gene delivery ability
Colloids and Surfaces B: Biointerfaces, 165, 18-27, 2018-05-01
[ Cell penetrating peptides (CPPs) , Cytotoxicity , Gene delivery , Indolicidin , Membrane perturbation , Molecular dynamics (MD) simulation ] -
The development of an alginate/polycaprolactone composite scaffold for in situ transfection application
Carbohydrate Polymers, 183, 29-36, 2018-03-01
[ Alginate , Biocompatibility , Coelectrospinning , Composite nanofibers , In situ transfection ] -
The conjugation of indolicidin to polyethylenimine for enhanced gene delivery with reduced cytotoxicity
Journal of Materials Chemistry B, 6, 36, 5781-5794, 2018-01-01 -
In situ transfection using layer-by-layer assembled chitosan/DNA multilayers
International Journal of Nanotechnology, 14, 12, 1031-1044, 2017-01-01 -
The regulation of osteogenesis using electroactive polypyrrole films
Polymers, 8, 7, 2016-07-13
[ Bone marrow stromal cells , Conductive polymer , Electroactive , Mineralization , Osteogenesis , Polypyrrole ] -
The control of cell orientation using biodegradable alginate fibers fabricated by near-field electrospinning
Materials Science and Engineering C, 62, 879-887, 2016-05-01
[ Alginate , Biocompatibility , Biodegradation , Cell alignment , Near-field electrospinning ] -
Virus immobilization on biomaterial scaffolds through biotin-avidin interaction for improving bone regeneration
Journal of Tissue Engineering and Regenerative Medicine, 10, 2, E63-E72, 2016-02-01
[ Biomaterial scaffolds , Biotin-avidin , Bone regeneration , Critical-sized bone defect , Gene delivery , Gene therapy , Tissue engineering ] -
Highly stretchable conductive polypyrrole film on a three dimensional porous polydimethylsiloxane surface fabricated by a simple soft lithography process
RSC Advances, 6, 114, 113344-113351, 2016-01-01 -
The consideration of indolicidin modification to balance its hemocompatibility and delivery efficiency
, 494, 1, 498-505, 2015-10-15
[ Cell-penetrating peptide , Direct penetration , Hydrophobicity , Indolicidin , Transmembrane mechanism ] -
Electrophoretic deposition to promote layer-by-layer assembly for in situ gene delivery application
Colloids and Surfaces B: Biointerfaces, 133, 171-178, 2015-09-01
[ Chitosan , Electrophoretic deposition , In situ transfection , Layer-by-layer assembly , Polypyrrole ] -
Microfluidic platform for human placenta-derived multipotent stem cells culture and applied for enhanced neuronal differentiation
Microfluidics and Nanofluidics, 18, 4, 587-598, 2015-01-01
[ Cell culture , Chemical stimulation , Microfluidic , Neuronal cell differentiation , Physical stimulation , Placenta-derived multipotent stem cells ] -
Toll-like receptor 6 and connective tissue growth factor are significantly upregulated in mitomycin-C-treated urothelial carcinoma cells under hydrostatic pressure stimulation
Genetic Testing and Molecular Biomarkers, 18, 6, 410-416, 2014-06-01 -
Electrical stimulation to promote osteogenesis using conductive polypyrrole films
Materials Science and Engineering C, 37, 1, 28-36, 2014-04-01
[ Bone marrow stromal cells , Direct current field , Electrical stimulation , Mineralization , Osteogenesis , Polypyrrole ] -
Fabrication and characterization of polymethylmethacrylate (PMMA) thin film by plasma polymerization used for cell culture
Surface and Coatings Technology, 259, PA, 20-26, 2014-01-01
[ Atomic force microscope , Fourier transform infrared spectroscopy , Human hepatocyte , Plasma polymerization , Polymethylmethacrylate ] -
The regulation of DNA adsorption and release through chitosan multilayers
Carbohydrate Polymers, 99, 394-402, 2014-01-01
[ Chitosan , Gene delivery , Interdiffusion , Layer-by-layer assembly , Polyelectrolyte multilayers ] -
The effect of alginate on DNA delivery from layer-by-layer assembled films
Carbohydrate Polymers, 101, 1, 240-248, 2014-01-01
[ Alginate , Gene delivery , In situ transfection , Layer-by-layer assembly , Polyelectrolyte multilayer ] -
Hydrostatic pressure enhances mitomycin C induced apoptosis in urothelial carcinoma cells
Urologic Oncology: Seminars and Original Investigations, 32, 1, 26.e17-26.e24, 2014-01-01 -
A novel application of indolicidin for gene delivery
, 456, 2, 293-300, 2013-09-24
[ Cell-penetrating peptide , Gene delivery , Indolicidin , Nonviral vectors , Transfection ] -
Coelectrospinning of chitosan/alginate fibers by dual-jet system for modulating material surfaces
Carbohydrate Polymers, 95, 2, 716-727, 2013-06-20
[ Alginate , Chitosan , Composite , Degradation , Electrospinning , Surface modification ] -
Effects of designed PLLA and 50:50 PLGA scaffold architectures on bone formation in vivo
Journal of Tissue Engineering and Regenerative Medicine, 7, 2, 99-111, 2013-02-01
[ Bone regeneration , Degradation , Designed architecture , Poly (L-lactic acid) , Poly (lactic-co-glycolic acid) , Scaffold , Solid freeform fabrication ] -
Use of biotinylated chitosan for substrate-mediated gene delivery
Bioconjugate Chemistry, 23, 8, 1587-1599, 2012-08-15 -
Optimization of DNA-directed immobilization on mixed oligo(ethylene glycol) monolayers for immunodetection
Analytical Biochemistry, 423, 1, 26-35, 2012-04-01
[ DNA-directed immobilization (DDI) , Oligo(ethylene glycol) (OEG) , Optimization , Self-assembled monolayer (SAM) , Surface plasmon resonance (SPR) ] -
Bone regeneration in defects compromised by radiotherapy
, 89, 1, 77-81, 2010-01-01
[ Bone regeneration , Gene delivery , Gene therapy. , Lyophilization , Radiotherapy , Tissue engineering ] -
The use of reactive polymer coatings to facilitate gene delivery from poly (ε-caprolactone) scaffolds
Biomaterials, 30, 29, 5785-5792, 2009-10-01
[ Adenovirus , Gene transfer , Interface , Polycaprolactone , Scaffold , Surface modification ] -
Digoxigenin modification of adenovirus to spatially control gene delivery from chitosan surfaces
Journal of Controlled Release, 135, 3, 250-258, 2009-05-05 -
Development of adenovirus immobilization strategies for in situ gene therapy
Journal of Gene Medicine, 10, 10, 1102-1112, 2008-12-01
[ Adenovirus , Avidin/biotin , Chitosan , Gene delivery , Surface modification , Tissue engineering ] -
Localized viral vector delivery to enhance in situ regenerative gene therapy
Gene Therapy, 14, 11, 891-901, 2007-06-01 -
Gene therapy strategies for craniofacial tissue engineering.
Journal of Musculoskeletal Neuronal Interactions, 7, 4, 2007-01-01 -
Covalent bonding of lysine to EVAL membrane surface to improve survival of cultured cerebellar granule neurons
Biomaterials, 24, 8, 1477-1486, 2003-04-01
[ Lysine , Neuron , Poly (ethylene-co-vinyl alcohol) (EVAL) ] -
Electrophoretic behavior of cerebellar granule neurons
Electrophoresis, 23, 13, 2001-2006, 2002-08-23
[ Cerebellar granule neurons , Electrophoretic mobility , Ion-binding , Surface dissociation reaction , Surface properties ] -
Establishment and characterization of a continuous cell line (GF-1) derived from grouper, Epinephelus coioides (Hamilton): A cell line susceptible to grouper nervous necrosis virus (GNNV)
Journal of Fish Diseases, 22, 3, 173-182, 1999-05-01
研討會著作
-
Temperature effect on nervous necrosis virus infection in grouper cell line and in grouper larvae
107-114, 1999-09-01
[ Fish nodavirus , Grouper , Nervous necrosis virus , Temperature effect ]
校內獲獎
- 115 研究傑出獎
- 114 研究傑出獎
- 113 研究傑出獎
- 113 優良論文貢獻獎
- 112 研究傑出獎
- 112 優良論文貢獻獎
- 111 研究傑出獎
- 110 研究傑出獎
- 109 研究傑出獎
- 108 研究傑出獎
期刊編輯
-
111 ~ 113
Frontiers in Bioengineering and Biotechnology
EISSN 2296-4185
擔任納米生物技術特刊的編輯委員會之審稿編輯 -
109 ~ 110
Polymers
EISSN 2073-4360
擔任"高分子材料於骨組織工程"特刊的客座主編 -
108 ~ 120
Experimental and Therapeutic Medicine
ISSN 1792-0981 EISSN 1792-1015
擔任學術編輯
- Composite Membrane and Manufacturing Method thereof [美國]
- 複合刺激生物反應器 [中華民國]
- 複合薄膜及其製作方法 [中華民國]
- 一種複合纖維 [中華民國]
國立中央大學